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Serum connective tissue markers as predictors of advanced fibrosis in patients with chronic hepatitis B and D

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dc.contributor.authorSeven, GÜLSEREN
dc.contributor.authorKaratayli, Senem Ceren
dc.contributor.authorKose, S. Kenan
dc.contributor.authorYakut, Mustafa
dc.contributor.authorKabacam, Gokhan
dc.contributor.authorToruner, Murat
dc.contributor.authorHeper, Aylin Okcu
dc.contributor.authorVoelker, Michael
dc.contributor.authorErden, Esra
dc.contributor.authorBozdayi, A. Mithat
dc.contributor.authorUzunalimoglu, Ozden
dc.contributor.authorBozkaya, Hakan
dc.contributor.authorYurdaydin, Cihan
dc.contributor.authorSchuppan, Detlef
dc.contributor.institutionauthorSEVEN, GÜLSEREN
dc.date.accessioned2021-01-22T20:59:13Z
dc.date.available2021-01-22T20:59:13Z
dc.date.issued2011-06-01T00:00:00Z
dc.description.abstractBackground/aims: Liver biopsy to assess fibrosis is invasive and prone to sampling error. While algorithms of serum markers to predict fibrosis stage have been described for chronic hepatitis C, these cannot be applied equally well to hepatitis B. Methods: We therefore determined 9 serum fibrosis markers, liver biochemical tests and ultrasound parameters in 109 consecutive adult patients with chronic hepatitis B and D. All patients had compensated liver disease. Using the METAVIR score, advanced disease was defined as fibrosis stage >= F2, and active inflammation as grade >= A2. A gold standard was created considering splenomegaly and or platelets <150,000 as indicators of advanced fibrosis irrespective of histology. Area under receiver operating characteristics curves was used for assessment of single markers and odds ratio for their combinations. Results: Patients with advanced disease were older, had lower albumin, higher gamma glutamyl transferase and lower platelet. Levels of 6 of the 9 fibrosis markers, tissue inhibitor of metalloproteinases-1, procollagen type III aminoterminal propeptide, matrix metalloproteinase-2, laminin, hyaluronan and collagen IV correlated with advanced fibrosis. Markers useful for fibrosis prediction also predicted marked inflammation. Using the gold standard, age, prothrombin time, gamma glutamyl transferase and albumin were independent predictors of fibrosis with odds ratio-s of 3.11, 4.18, 3.35 and 5.25, respectively. Their combined use predicted fibrosis with an odds ratio of 228.8. Tissue inhibitor of metalloproteinases-1 and hyaluronan were powerful predictors of fibrosis (Odds ratio-s of 8.65 and 8.38). Their combined use revealed an odds ratio of 28.6, when compared with the gold standard. Conclusion: In conclusion., advanced liver fibrosis in chronic hepatitis B and D may be predicted with use of these two fibrosis markers.
dc.identifier.citationSeven G., Karatayli S. C. , Kose S. K. , Yakut M., Kabacam G., Toruner M., Heper A. O. , Voelker M., Erden E., Bozdayi A. M. , et al., -Serum connective tissue markers as predictors of advanced fibrosis in patients with chronic hepatitis B and D-, TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.22, ss.305-314, 2011
dc.identifier.doi10.4318/tjg.2011.0217
dc.identifier.scopus79961123125
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28115
dc.identifier.wosWOS:000293434100011
dc.titleSerum connective tissue markers as predictors of advanced fibrosis in patients with chronic hepatitis B and D
dc.typeArticle
dspace.entity.typePublication
local.avesis.id21ee874d-a744-4f61-96de-b615f235f076
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublicationfedf47e7-d7dd-44db-ada5-60bbaef0ae5b
relation.isAuthorOfPublication.latestForDiscoveryfedf47e7-d7dd-44db-ada5-60bbaef0ae5b
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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