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Antibacterial and cytotoxic properties of boron-containing dental composite

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dc.contributor.authorŞahin, Fikrettin
dc.contributor.authorDemirci, Selami
dc.contributor.authorKAYA, MUSTAFA SARP
dc.contributor.authorDoğan, Ayşegül
dc.contributor.authorKalay, Şaban
dc.contributor.authorAltin, Nergis Ozlem
dc.contributor.authorYarat, Aysen
dc.contributor.authorAkyuz, Serap
dc.contributor.institutionauthorKAYA, MUSTAFA SARP
dc.date.accessioned2020-10-29T23:08:29Z
dc.date.available2020-10-29T23:08:29Z
dc.date.issued2015-01-01T00:00:00Z
dc.description.abstractSecondary dental caries are one of the major reasons for restoration replacements. Incorporating antimicrobial properties into dental materials would limit the initiation and progression of dental caries. In the current study, dental composites having 1%, 5%, and 10% (w/w) sodium pentaborate pentahydrate were prepared and analyzed for their mechanical properties, degree of monomer conversion (DC) rate, antibacterial effects against Streptococcus mutans, and biocompatibility with human dental pulp stem cells (hDPSCs). Incorporation of boron into the composites significantly decreased flexural strength and DC in a dose-dependent manner, but the value for 1% boron-containing composite still remained within acceptable levels. Compressive strength and diametral tensile strength were not found to be different from those of controls. Although no inhibition zone was detected in an agar-well diffusion assay for any materials tested, significant bacterial growth inhibition was obtained in a direct contact test for boron-containing composites. Immunocytochemical and lineage-specific gene expression analysis revealed that composites with boron content increased the osteogenic and odontogenic capacity of hDPSCs. Boron-containing dental composites showed promising results for future clinical applications, displaying nontoxic, osteogenic, and odontogenic-inducing characteristics with remarkable antibacterial activity against S. mutans, and are hence potentially able to prevent secondary caries.
dc.identifier.citationDemirci S., KAYA M. S. , Doğan A., Kalay Ş., Altin N. O. , Yarat A., Akyuz S., Şahin F., -Antibacterial and cytotoxic properties of boron-containing dental composite-, TURKISH JOURNAL OF BIOLOGY, cilt.39, ss.417-426, 2015
dc.identifier.doi10.3906/biy-1408-18
dc.identifier.scopus84929161509
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26916
dc.identifier.wosWOS:000356358200008
dc.titleAntibacterial and cytotoxic properties of boron-containing dental composite
dc.typeArticle
dspace.entity.typePublication
local.avesis.idd23e5564-c20b-4ff9-8548-1275c16d9a4f
local.publication.isinternational1
relation.isAuthorOfPublication2c09c3df-f7e2-4024-b685-ca3b8cdd8264
relation.isAuthorOfPublication.latestForDiscovery2c09c3df-f7e2-4024-b685-ca3b8cdd8264
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