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Estrogen Receptor Positive/Progesterone Receptor Negative Breast Carcinomas: A Subgroup Deserves Particular Interest

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dc.contributor.authorGucin, ZÜHAL
dc.contributor.authorGECER, Melin Ozgun
dc.contributor.authorBuyukpinarbasili, NUR
dc.contributor.authorSONMEZ, Cavide
dc.contributor.authorErsoy, YELİZ EMİNE
dc.contributor.authorMUSLUMANOGLU, Mahmut
dc.contributor.institutionauthorGÜCİN, ZÜHAL
dc.contributor.institutionauthorBÜYÜKPINARBAŞILI, NUR
dc.contributor.institutionauthorERSOY, YELIZ EMINE
dc.date.accessioned2019-10-05T21:33:48Z
dc.date.available2019-10-05T21:33:48Z
dc.date.issued2015-08-01
dc.description.abstractObjective: Breast carcinomas positive for the estrogen receptor (ER+) but negative for the progesterone receptor (PR−) have unfavorable prognostic features and are resistant to tamoxifen therapy. The goal of this study was to highlight the significance of PR− breast carcinomas. Methods: Therefore, 146 breast carcinomas comprising 87 ER+/PR+ and 59 ER+/PR− carcinomas were examined. These two groups were compared in terms of age; tumor type; tumor size; histologic grade; presence of an in situ component; lymphovascular and perineural invasion; and ER, PR, c-Erb B2, Ki-67, and epidermal growth factor receptor (EGFR) status. Results: While the number of metastatic lymph node and related pN2+pN3 tumors were found to be significantly higher in the ER+/ PR− group, the differences with respect to the tumor size, metastatic lymph node size, and frequency of lymphovascular invasion were nearly significant. Conclusion: ER+/PR− tumors have an unfavorable prognosis and show a clinical behavior closer to triple negative ones, although classified as luminal tumors. Revealing the mechanisms causing these differences will enhance the success of breast cancer therapy.
dc.identifier10.1093/asj/sju048
dc.identifier.citationGucin Z., GECER M. O. , Buyukpinarbasili N., SONMEZ C., Ersoy Y. E. , MUSLUMANOGLU M., -Estrogen Receptor Positive/Progesterone Receptor Negative Breast Carcinomas: A Subgroup Deserves Particular Interest-, BEZMIALEM SCIENCE, cilt.3, ss.29-32, 2015
dc.identifier.trdizin187737
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7621
dc.identifier.wosWOS:000370840500003
dc.language.isoen
dc.subjectBreast carcinoma
dc.subjectestrogen receptor
dc.subjectprogesterone receptor
dc.subjectluminal type
dc.subjectprognosis
dc.titleEstrogen Receptor Positive/Progesterone Receptor Negative Breast Carcinomas: A Subgroup Deserves Particular Interest
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameAesthetic surgery journal
local.avesis.idbd636138-d523-4f9d-9dda-23a7ef9dc641
local.avesis.response7497
local.publication.isinternational1
relation.isAuthorOfPublication874eeba5-cd5f-4437-9bdc-55caae8104f2
relation.isAuthorOfPublication07a102ad-e53c-46b9-b3aa-bdb5723b1e7c
relation.isAuthorOfPublication29a098c6-acc4-4e05-af39-eeffbc7be778
relation.isAuthorOfPublication.latestForDiscovery874eeba5-cd5f-4437-9bdc-55caae8104f2
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