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Dual-Responsive pH and Temperature Sensitive Nanoparticles Based on Methacrylic Acid and Di(ethylene glycol) Methyl Ether Methacrylate for the Triggered Release of Drugs

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dc.contributor.authorKHINE, Yee Yee
dc.contributor.authorJIANG, Yanyan
dc.contributor.authorDag, AYDAN
dc.contributor.authorLu, Hongxu
dc.contributor.authorSTENZEL, Martina H.
dc.contributor.institutionauthorDAĞ, AYDAN
dc.date.accessioned2019-10-05T21:12:15Z
dc.date.available2019-10-05T21:12:15Z
dc.date.issued2015-08-01
dc.description.abstractA series of thermo-and pH-responsive poly(methyl methacrylate)-block-poly[methacrylic acid-co-di(ethylene glycol) methyl ether methacrylate] PMMA-b-P[MAA-co-DEGMA] block copolymers were synthesized by RAFT polymerization and self-assembled into micelles. The molar ratio of MAA was altered from 0-12% in order to modulate the lower critical solution temperature (LCST) of PDEGMA. The release of the drug albendazole from the micelle was strongly dependent on the temperature and the LCST value of the polymer. Systems below the LCST released the drug slowly while increasing the temperature above the LCST or decreasing the pH value to 5 resulted in the burst-like release of the drug. ABZ delivered in this pH-responsive drug carrier had a higher toxicity than the free drug or the drug delivered in a non-responsive drug carrier.
dc.identifier
dc.identifier.citationKHINE Y. Y. , JIANG Y., Dag A., Lu H., STENZEL M. H. , -Dual-Responsive pH and Temperature Sensitive Nanoparticles Based on Methacrylic Acid and Di(ethylene glycol) Methyl Ether Methacrylate for the Triggered Release of Drugs-, MACROMOLECULAR BIOSCIENCE, cilt.15, ss.1091-1104, 2015
dc.identifier.pubmed25955566
dc.identifier.urihttps://hdl.handle.net/20.500.12645/6749
dc.language.isoen
dc.titleDual-Responsive pH and Temperature Sensitive Nanoparticles Based on Methacrylic Acid and Di(ethylene glycol) Methyl Ether Methacrylate for the Triggered Release of Drugs
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameINTERNATIONAL JOURNAL OF CLINICAL PHARMACY
local.avesis.ida87eeb3f-83ba-40d5-8c0c-43735024a355
local.avesis.response6625
relation.isAuthorOfPublication5053fdfd-57cd-423a-9076-db4bab8cbe3d
relation.isAuthorOfPublication.latestForDiscovery5053fdfd-57cd-423a-9076-db4bab8cbe3d
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