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Assessment of the 24th Week Success of Anti-Retroviral Therapy in the Action against HIV in Istanbul Database: Results from a Region with Increasing Incidence

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dc.contributor.authorBolukçu, Sibel
dc.contributor.authorMETE, BİLGÜL
dc.contributor.authorGündüz, Alper
dc.contributor.authorKaraosmanoglu, Hayat Kumbasar
dc.contributor.authorSargın, Fatma
dc.contributor.authorDURDU, BÜLENT
dc.contributor.authorAydin, Ozlem Altuntas
dc.contributor.authorYildiz, Dilek
dc.contributor.authorDÖKMETAŞ, İLYAS
dc.contributor.authorAsian, Turan
dc.contributor.authorTABAK, ÖMER FEHMİ
dc.contributor.institutionauthorBOLUKÇU, SİBEL
dc.contributor.institutionauthorDURDU, BÜLENT
dc.date.accessioned2019-11-17T23:43:48Z
dc.date.available2019-11-17T23:43:48Z
dc.date.issued2019-05-01
dc.description.abstractWe aimed to assess the 24-week virological and immunological success of the treatment of treatment-naive and treatment-experienced patients included in the Action against HIV in Istanbul (ACTHIV-IST) database. The ACTHIV-IST database was screened retrospectively from January 2012 to January 2014. The data for these patients such as age, sex, treatment-naive or treatment-experienced status, date of diagnosis, date of commencing antiretroviral therapy, antiretroviral therapy regimen, CD4+ cell count, and viral load before and after therapy were analyzed. In the 24th week of antiretroviral therapy, there were 40 (17.9%) and 29 (14.1%) virological and immunological failures, respectively. Virological failure (VF) was associated with a baseline viral load > 100,000 copies (p = 0.004). A CD4+ cell count lower than 200 cells/µl was not found to be associated with VF (p = 0.843). Immunological failure was substantially rare in patients with a baseline CD4+ cell count > 200 cells/µl (p = 0.005). Although an HIV-RNA 侑 100,000 copies/ml was protective against VF in the 24th week, in individuals with an HIV-RNA > 100,000 copies/ml, VF was 3.2 times more likely to occur. Baseline VF was the most predictive parameter to estimate 24th week virological success and VF. VF is an important prognostic parameter resulting in CD4+ cell depletion, AIDS-related events, and increased mortality.en
dc.identifier.citationBolukçu S., METE B., Gündüz A., Karaosmanoglu H. K. , Sargın F., DURDU B., Aydin O. A. , Yildiz D., DÖKMETAŞ İ., Asian T., et al., -Assessment of the 24th Week Success of Anti-Retroviral Therapy in the Action against HIV in Istanbul Database: Results from a Region with Increasing Incidence-, JAPANESE JOURNAL OF INFECTIOUS DISEASES, cilt.72, ss.173-178, 2019
dc.identifier.doi10.7883/yoken.jjid.2018.105
dc.identifier.pubmed30700656
dc.identifier.scopus85066467534
dc.identifier.urihttps://hdl.handle.net/20.500.12645/10432
dc.identifier.wosWOS:000471741500006
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleAssessment of the 24th Week Success of Anti-Retroviral Therapy in the Action against HIV in Istanbul Database: Results from a Region with Increasing Incidence
dc.typeArticle
dspace.entity.typePublication
local.avesis.idaf6676ea-7383-4df4-9e19-def2d1e165b4
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isAuthorOfPublication9814f802-a79c-45fd-aa3e-f1ba9d40884b
relation.isAuthorOfPublication.latestForDiscovery08e52ea2-7b47-480d-b19f-ca95826db4c1
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