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A Study On Synthesis, Biological Activities and Molecular Modelling of Some Novel Trisubstituted 1,2,4-Triazole Derivatives

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dc.contributor.authorGultekin, Ergun
dc.contributor.authorKOLCUOĞLU, YAKUP
dc.contributor.authorAkdemir, ATİLLA
dc.contributor.authorSirin, Yakup
dc.contributor.authorBektas, Hakan
dc.contributor.authorBEKİRCAN, OLCAY
dc.contributor.institutionauthorAKDEMİR, ATİLLA
dc.date.accessioned2019-10-05T14:52:37Z
dc.date.available2019-10-05T14:52:37Z
dc.date.issued2018-08-23
dc.description.abstractIn this study, 1-(4-substitued benzyl)-3,5-diphenyl-1H-1,2,4-triazoles (2 a-e) and ethyl(3,5-diphenyl-/H-1,2,4-triazole-1-yl) acetate (3) were synthesized starting from 3,5-diphenyl-/H1,2,4-triazole (1). The ethyl acetate derivative (3) was converted to 2-(3,5-diphenyl-1H-1,2,4-triazole-1-yl)acetohydrazide (4) in ethanolic medium with hydrazine hydrate. The reaction of the acetohydrazide (4) with suitable isothiocyanates generate 2-[(3, 5-diphenyl-1H-1,2,4-triazole-1-yl)acetyl]-4-methyl/phenyh-Ithiosemicarbazide (5a,b). The cyclization of the thiosemicarbazide (5a,b) in the presence of NaOH (2 M) resulted in the formation of 5-[(3,5-diphenyl-1H-1,2,4-triazole-1-yl)methyl]-4methyl/phenyl-2,4-dihidro-3H-1,2,4-triazole-3-thiol (6a,b). Finally, the synthesized 1,2,4-triazole-3-thiols (6a,b) were converted to their 5-substituebenzyl derivatives (7 a-j). All of the synthesized compounds (1-7) were also examined for antioxidant capacities, and antiurease and anti-acetylcholinesterase (anti-AChE) activities. It has been found that antioxidant capacity and anti-urease activity of the compound 7f is very good in biochemically active compounds.
dc.identifier10.1111/psyg.12413
dc.identifier.citationGultekin E., KOLCUOĞLU Y., Akdemir A., Sirin Y., Bektas H., BEKİRCAN O., -A Study On Synthesis, Biological Activities and Molecular Modelling of Some Novel Trisubstituted 1,2,4-Triazole Derivatives-, CHEMISTRYSELECT, cilt.3, ss.8813-8818, 2018
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4937
dc.language.isoen
dc.titleA Study On Synthesis, Biological Activities and Molecular Modelling of Some Novel Trisubstituted 1,2,4-Triazole Derivatives
dc.typeArticle
dspace.entity.typePublication
local.article.journalnamePSYCHOGERIATRICS
local.avesis.id79715f75-80c1-44d8-9c50-ffb8a3e659a8
local.avesis.response4807
relation.isAuthorOfPublication19bc513a-c695-4e72-ba1d-83b8d6c574c8
relation.isAuthorOfPublication.latestForDiscovery19bc513a-c695-4e72-ba1d-83b8d6c574c8
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