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Paraoxonase-1 Phenotype and Its Relationship with Mean Platelet Volume and Oxidative Stress in Coronary Artery Disease

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dc.contributor.authorSELEK, ŞAHBETTİN
dc.contributor.authorÖZER, ÖMER FARUK
dc.contributor.authorGOKTEKİN, Omer
dc.contributor.authorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.authorKALINBACOGLU, Ceren
dc.contributor.authorISLEK, Irem
dc.contributor.authorISLEK, Tuğba
dc.contributor.authorARPACI, Beyza
dc.contributor.authorErol, Neval
dc.contributor.authorMEYDAN, Sedat
dc.contributor.authorGÜLER, ERAY METİN
dc.contributor.institutionauthorSELEK, ŞAHABETTİN
dc.contributor.institutionauthorÖZER, ÖMER FARUK
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorMEYDAN, SEDAT
dc.contributor.institutionauthorGÜLER, ERAY METİN
dc.date.accessioned2019-10-05T22:05:58Z
dc.date.available2019-10-05T22:05:58Z
dc.date.issued2015-09-01
dc.description.abstractObjective: Paraoxonase-1 (PON1) 192 QR polymorphism is believed to be an important protective factor for coronary artery disease (CAD); oxidative stress plays a key role in the development of atherosclerotic CAD. Mean platelet volume (MPV) is also central to the processes, including pathophysiology of CAD and endothelial dysfunction. Thus, we aimed to determine the PON1 phenotype, MPV, and oxidative stress parameters in patients with angiographically proven CAD and to compare them with those in healthy subjects. Methods: Fifty-five CAD patients were diagnosed according to the angiography results, and 37 healthy subjects were present in this study. Serum paraoxonase and arylesterase activities were spectrophotometrically measured. Phenotype distribution was evaluated by the salt-stimulated paraoxonase activity according to arylesterase activity. Oxidative stress markers were evaluated by measuring serum total oxidant status (TOS) and total antioxidant status (TAS) as well as oxidative stress index. Results: In this study, the ratio of salt-stimulated paraoxonase/ OSI levels (S-PON1/OSI) were lower in the CAD patients and the differences were statistically significant (p<0.05). Therefore, the ratio of salt-stimulated paraoxonase/MPV (S -PON1/MPV) and S- PON1/OSI level were significantly different in the CAD patients as compared with controls group (p<0.01). Conclusion: Our study has suggested that S-PON1/OSI and SPON1/ MPV may play a significant role in CAD. To the best of our knowledge, the present study is the first to study the relationship among PON1 phenotype, MPV, and OSI in CAD patients. Thus, lowering of the oxidative stress and the regulation of MPV strategies may be a promising approach for the treatment of CAD.en
dc.identifier10.5137/1019-5149.jtn.15678-15.1
dc.identifier.citationSELEK Ş., ÖZER Ö. F. , GOKTEKİN O., KOÇYİĞİT A., KALINBACOGLU C., ISLEK I., ISLEK T., ARPACI B., EROL N., -Paraoxonase-1 Phenotype and Its Relationship with Mean Platelet Volume and Oxidative Stress in Coronary Artery Disease-, BEZMIALEM SCIENCE, cilt.3, ss.24-28, 2015
dc.identifier.doi10.14235/bs.2015.492
dc.identifier.trdizin187735
dc.identifier.urihttps://hdl.handle.net/20.500.12645/8901
dc.identifier.wosWOS:000370840500002
dc.identifier.yoksis4796324
dc.language.isoen
dc.subjectParaoxonase
dc.subjectarylesterase
dc.subjectMPV
dc.subjecttotal antioxidant status
dc.subjecttotal oxidant status
dc.subjectoxidative stress index
dc.titleParaoxonase-1 Phenotype and Its Relationship with Mean Platelet Volume and Oxidative Stress in Coronary Artery Disease
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTurkish neurosurgery
local.avesis.iddd420113-91ca-4c77-80dc-883f89305760
local.avesis.response8777
local.publication.isinternational0
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relation.isAuthorOfPublication.latestForDiscovery8eb7d539-8ea4-435c-830e-8ef630342c7d
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