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The effect of neoadjuvant therapy on the size, number, and distribution of mesorectal lymph nodes

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dc.contributor.authorYegen, Gulcin
dc.contributor.authorKeskin, Metin
dc.contributor.authorBuyuk, Melek
dc.contributor.authorKunduz, ENVER
dc.contributor.authorBalik, Emre
dc.contributor.authorSaglam, Esra Kaytan
dc.contributor.authorKapran, Yersu
dc.contributor.authorAsoglu, Oktar
dc.contributor.authorGulluoglu, Mine
dc.contributor.institutionauthorKUNDUZ, ENVER
dc.date.accessioned2019-10-05T15:09:02Z
dc.date.available2019-10-05T15:09:02Z
dc.date.issued2016-02-01
dc.description.abstractThe current therapeutic approach to patients with locally advanced rectal cancer is neoadjuvant radiotherapy or chemoradiotherapy followed by total mesorectal excision. We aimed to investigate the number, size, and distribution of metastatic and nonmetastatic lymph nodes within the mesorectum; whether neoadjuvant therapy has any impact on the number and size of the lymph nodes; and the impact of metastatic lymph node localization on overall and disease-free survival. Specimens from 50 consecutive patients with stage rectal cancer receiving either neoadjuvant radiotherapy or chemoradiotherapy were investigated. Lymph node dissection was carried out by careful visual inspection and palpation. The localization of the each lymph node within the mesorectum and the relation with the tumor site were noted. The size and the number of lymph nodes retrieved decreased significantly with neoadjuvant therapy. Majority of the metastatic and nonmetastatic lymph nodes were located at or proximally to the tumor level and posterior side of the mesorectum. No relation was observed between the overall and disease-free survival, and the localization of the metastatic lymph nodes. Presence of lymph node metastases proximal to the tumor level has no impact on survival compared with the presence of lymph node metastasis only in the peritumoral region of the mesorectum. Although neoadjuvant therapy decreases the size and the number of lymph nodes, reaching an ideal number of lymph nodes for accurate staging is still possible with careful naked eye examination and dissection of perirectal fat. As the majority of metastatic and nonmetastatic lymph nodes are located in peritumoral and proximal compartment, and posterior side of the mesorectum, these regions should be the major interest of dissection. (C) 2015 Elsevier Inc. All rights reserved.
dc.identifier10.1097/00003072-200501000-00026
dc.identifier.citationYegen G., Keskin M., Buyuk M., Kunduz E., Balik E., Saglam E. K. , Kapran Y., Asoglu O., Gulluoglu M., -The effect of neoadjuvant therapy on the size, number, and distribution of mesorectal lymph nodes-, ANNALS OF DIAGNOSTIC PATHOLOGY, cilt.20, ss.29-35, 2016
dc.identifier.doi10.1016/j.anndiagpath.2015.10.008
dc.identifier.scopus84966397621
dc.identifier.urihttps://hdl.handle.net/20.500.12645/5583
dc.identifier.wosWOS:000369122600006
dc.language.isoen
dc.titleThe effect of neoadjuvant therapy on the size, number, and distribution of mesorectal lymph nodes
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameClinical nuclear medicine
local.avesis.id894269e6-c961-470e-9d1b-220df877a9fb
local.avesis.response5453
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication7291ef45-f049-4fa7-93fd-27aa822e7bf9
relation.isAuthorOfPublication.latestForDiscovery7291ef45-f049-4fa7-93fd-27aa822e7bf9
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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