Publication:
Immunoexpression of TTF-1 in Non-Lung Tumors

Simple item page
dc.contributor.authorTOSUNER, ZEYNEP
dc.contributor.authorARICI, Dilek Sema
dc.contributor.authorGÜCİN, ZÜHAL
dc.contributor.authorBÜYÜKPINARBAŞILI, NUR
dc.contributor.authorSÖNMEZ, FATMA CAVİDE
dc.contributor.authorYILDIZ, PELİN
dc.contributor.institutionauthorTOSUNER, ZEYNEP
dc.contributor.institutionauthorARICI, DILEK SEMA
dc.contributor.institutionauthorGÜCİN, ZÜHAL
dc.contributor.institutionauthorBÜYÜKPINARBAŞILI, NUR
dc.contributor.institutionauthorSÖNMEZ, FATMA CAVİDE
dc.contributor.institutionauthorYILDIZ, PELİN
dc.date.accessioned2020-10-22T19:24:52Z
dc.date.available2020-10-22T19:24:52Z
dc.date.issued2014-12-01T00:00:00Z
dc.description.abstractObjective: Thyroid transcription factor-1 (TTF-1) immunoexpression is frequently determined in small-cell lung carcinomas, as well as primary lung adenocarcinomas. While dealing with metastatic carcinomas, TTF-1 immunoexpression is a significant indicator of primary lung carcinomas. Recent studies have revealed that TTF-1 immunoexpression is also defined in non-lung cancers, such as squamous cell carcinomas of different sites and certain neuroendocrine tumors. The verified data obtained from these studies indicate that a straightforward diagnosis of primary lung carcinoma in cases with positive TTF-1 immunoexpression can cause diagnostic contradictions. The aim of our study is to investigate the immunoexpression status of TTF-1 in common non-lung tumors. Methods: A total of 85 cases that were diagnosed in our institute between the years 2011-2012 were included in our study. After a review of the pathological slides prepared from these tumors [colon adenocarcinoma (n: 15), renal cell carcinoma (n: 15), prostate adenocarcinoma (n: 15), invasive papillary urothelial carcinoma (n: 15), invasive ductal carcinoma of breast (n: 15), and neuroendocrine tumors (n: 10)] TTF-1 immunohistochemistry was applied. Semiquantative evaluation based on the distribution and intensity of the staining was performed by two pathologists, respectively. Results: Positive immunostaining was evident in only 1 case of colon adenocarcinoma out of 85 cases. Conclusion: Our study demonstrated that TTF-1 immunoexpression is a very rare finding (1%) in non-lung tumors. This result provides that anti-TTF-1 is a reliable antibody in the interpretation of primary lung carcinomas. In fact, further studies with a large number of cases are needed to confirm the sensitivity and specificity of TTF-1.en
dc.identifier.citationTOSUNER Z., ARICI D. S. , GÜCİN Z., BÜYÜKPINARBAŞILI N., SÖNMEZ F. C. , YILDIZ P., -Immunoexpression of TTF-1 in Non-Lung Tumors-, BEZMIALEM SCIENCE, cilt.2, ss.95-97, 2014
dc.identifier.doi10.14235/bs.2014.336
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24467
dc.identifier.urihttp://www.bezmialemscience.org/archives/archive-detail/article-preview/mmunoexpression-of-ttf-1-in-non-lung-tumors/20413
dc.identifier.wosWOS:000218644200002
dc.subjectTTF-1
dc.subjectimmunohistochemistry
dc.subjectnon-lung tumors
dc.titleImmunoexpression of TTF-1 in Non-Lung Tumors
dc.typeArticle
dspace.entity.typePublication
local.avesis.idba3b65b5-1adc-40f2-bb0a-0c2e7dc1b7f2
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication78184ff0-7bfc-4a7f-b855-737174d8fd00
relation.isAuthorOfPublication39582b2a-f3bf-47fe-9483-87678e56820e
relation.isAuthorOfPublication874eeba5-cd5f-4437-9bdc-55caae8104f2
relation.isAuthorOfPublication07a102ad-e53c-46b9-b3aa-bdb5723b1e7c
relation.isAuthorOfPublicationf2e28f00-b1be-4efc-a354-4b184e0989bf
relation.isAuthorOfPublication4c9a734d-36ee-4704-9e15-7012fd2ca3fb
relation.isAuthorOfPublication.latestForDiscovery78184ff0-7bfc-4a7f-b855-737174d8fd00
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Immunoexpression of TTF-1 in Non-Lung Tumors.pdf
Size:
152.65 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Bezmialem Science Koleksiyonu