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Mmp-9 and Fascin-1 Expression in Endometrioid-Type Endometrial Carcinoma and Their Prognostic Value

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dc.contributor.authorTECELLİOĞLU, FAHRİYE SEÇİL
dc.contributor.authorAKPOLAT, NUSRET
dc.contributor.authorŞAHİN, NURHAN
dc.contributor.institutionauthorŞAHİN, NURHAN
dc.date.accessioned2022-01-24T20:59:12Z
dc.date.available2022-01-24T20:59:12Z
dc.date.issued2021-03-01T00:00:00Z
dc.description.abstractBackgrounds Matrix metalloproteinases (MMP) and fascin-1 play roles in epithelial-mesenchymal transition and tumour invasion. Aims This study was performed to investigate the relationships of fascin-1 and MMP-9 expression with prognostic parameters in endometrioid-type endometrial carcinoma (EEC). Methods A total of 100 cases of EEC were included in the study. Tissues were stained with antibodies against fascin-1 and MMP-9. The relationships between the immunohistochemical findings and clinicopathological prognostic parameters of EEC were examined. Results Tumour diameter was significantly related to lymphovascular invasion, FIGO stage and FIGO grade (p 2 cm was associated with a poor prognosis. The staining score for fascin-1 was 5 in 19 cases (p > 0.05), and that for MMP-9 was 5 in 61 cases (p > 0.05). Neither fascin-1 nor MMP-9 expression was significantly related to any of the clinicopathological parameters examined. Conclusion There were no significant relationships of fascin-1 and MMP-9 expression with the clinicopathological parameters of EEC. The results of this study suggested that these molecules do not contribute to the clinical behaviour of EECs. A tumour size > 2 cm is associated with a poor prognosis in EEC patients. To verify these results, more studies are needed with larger patient groups.
dc.identifier.citationTECELLİOĞLU F. S. , AKPOLAT N., ŞAHİN N., -Mmp-9 and Fascin-1 Expression in Endometrioid-Type Endometrial Carcinoma and Their Prognostic Value-, INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY, cilt.19, sa.1, 2021
dc.identifier.doi10.1007/s40944-020-00492-7
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30278
dc.identifier.wosWOS:000617130500001
dc.titleMmp-9 and Fascin-1 Expression in Endometrioid-Type Endometrial Carcinoma and Their Prognostic Value
dc.typeArticle
dspace.entity.typePublication
local.avesis.idbb31430b-2341-4b2b-ba92-46f4888294be
local.publication.isinternational1
relation.isAuthorOfPublication84f8cc2e-0a04-41e1-b473-7f2af3f72119
relation.isAuthorOfPublication.latestForDiscovery84f8cc2e-0a04-41e1-b473-7f2af3f72119
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