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Light-responsive azobenzene-based glycopolymer micelles for targeted drug delivery to melanoma cells

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dc.contributor.authorPEARSON, Samuel
dc.contributor.authorVITUCCI, Dylan
dc.contributor.authorKHINE, Yee Yee
dc.contributor.authorDag, AYDAN
dc.contributor.authorLu, Hongxu
dc.contributor.authorSAVE, Maud
dc.contributor.authorBILLON, Laurent
dc.contributor.authorSTENZEL, Martina H.
dc.contributor.institutionauthorDAĞ, AYDAN
dc.date.accessioned2019-10-05T14:37:15Z
dc.date.available2019-10-05T14:37:15Z
dc.date.issued2015-08-01
dc.description.abstractLight-responsive glycopolymer micelles were produced by the self-assembly of amphiphilic block copolymers containing azobenzene and beta-galactose units. These well-defined block copolymers were synthesised firstly by the RAFT polymerisation of an azobenzene methacrylate monomer (AzoMA) to produce two short azobenzene macroRAFT agents containing 7 and 15 monomer units. Chain extension with a second block of similar to 150 or similar to 250 sugar units comprising of a protected beta-galactose monomer (beta-AcGalEtMA) generated four block copolymers, which were converted to amphiphilic structures by deprotection of the acetyl groups on the sugar units. Micelles with well-defined sizes of 26-50 nm were produced by self-assembly in water. The azobenzene units isomerised very rapidly to their more polar cis isomers under UV irradiation, reaching the photostationary state within 2 min, with reversion to the trans state taking several hours in the dark. This transition to the more polar cis state is an important criteria for aiding expulsion of a hydrophobic payload. In cell studies, unloaded micelles showed low cytotoxicity, and micelles loaded with the model hydrophobic compound Nile red demonstrated high cellular uptake in human melanoma A375 cells, demonstrating their suitability as a potential drug delivery system for melanoma. (C) 2015 Elsevier Ltd. All rights reserved.
dc.description.sponsorship
dc.description.sponsorshipTürkiye Bilimsel Ve Teknolojik Araştırma Kurumu ( Tübitak )
dc.identifier10.1016/j.leukres.2009.03.026
dc.identifier.citationPEARSON S., VITUCCI D., KHINE Y. Y. , Dag A., Lu H., SAVE M., BILLON L., STENZEL M. H. , -Light-responsive azobenzene-based glycopolymer micelles for targeted drug delivery to melanoma cells-, EUROPEAN POLYMER JOURNAL, cilt.69, ss.616-627, 2015
dc.identifier.doi10.1016/j.eurpolymj.2015.04.001
dc.identifier.scopus84937971538
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4301
dc.identifier.wosWOS:000359504800056
dc.language.isoen
dc.titleLight-responsive azobenzene-based glycopolymer micelles for targeted drug delivery to melanoma cells
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameLeukemia research
local.avesis.id68c10a7c-ef6b-4183-9a65-c0050de3d4a5
local.avesis.response4171
local.publication.isinternational1
relation.isAuthorOfPublication5053fdfd-57cd-423a-9076-db4bab8cbe3d
relation.isAuthorOfPublication.latestForDiscovery5053fdfd-57cd-423a-9076-db4bab8cbe3d
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