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Apoptotic effects of dipyrido [3,2-a:2 -,3 --c] phenazine (dppz) Au(III) complex against diethylnitrosamine/phenobarbital induced experimental hepatocarcinogenesis in rats

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dc.contributor.authorTekin, Neslihan
dc.contributor.authorUstuner, Mehmet C.
dc.contributor.authorAkyuz, Fahrettin
dc.contributor.authorOzbayer, Cansu S.
dc.contributor.authorAydin, Ozlem
dc.contributor.authorBenkli, KADRİYE
dc.contributor.authorBurukoglu, Dilek
dc.contributor.authorDegirmenci, Irfan
dc.contributor.authorOzden, Hilmi
dc.contributor.institutionauthorBENKLİ, KADRIYE
dc.date.accessioned2020-10-29T21:28:21Z
dc.date.available2020-10-29T21:28:21Z
dc.date.issued2014-08-01T00:00:00Z
dc.description.abstractWe evaluated the effects of dipyrido [3,2-a:2-,3--c] phenazine (dppz) Au(III) complex ([Au(dppz)Cl-2]Cl) on apoptosis during chemically induced hepatocellular carcinoma. 48 male Spraque-Dawley rats were divided into six groups; group I (control), group II [Dimethyl sulfoxide (DMSO)], group III ([Au(dppz)Cl-2]Cl), group IV [diethylnitrosamine + Phenobabital (DEN + PB)], group V (DEN + PB + [Au(dppz)Cl-2]Cl (2nd week)), and group VI (DEN + PB + [Au(dppz)Cl-2]Cl (7th week). The rats in groups IV through VI were administrated with DEN in a single dose of intraperitoneal 175 mg/kg. After 2 weeks of DEN administration, these groups of rats were given daily PB in a dose of 500 ppm. In group V, after two weeks of DEN administration, [Au(dppz)Cl-2]Cl complex (2 mg/kg) was given once a week by intraperitoneal injection. In the group VI, the rats were given a dose of 2 mg/kg [Au(dppz)Cl-2]Cl complex once a week, 7 weeks after DEN administration. At the end of the study, blood and tissue samples were collected from the rats to determine levels of serum AST, ALT, and LDH, and caspase 3, p53, Bax, Bcl-2 and DNA fragmentation in liver. AST, ALT, LDH, and Bcl-2 levels were higher in group IV, compared to group I, but caspase 3 and p53 levels were lower. In group V, caspase 3, p53, Bax, and DNA fragmentation levels were higher than those of group IV. Caspase 3 and p53 levels increased in group VI compared with group IV. In conclusion, [Au(dppz)Cl-2]Cl complex induced apoptosis by elevating levels of caspase 3, p53, Bax, and DNA fragmentation.
dc.identifier.citationTekin N., Ustuner M. C. , Akyuz F., Ozbayer C. S. , Aydin O., Benkli K., Burukoglu D., Degirmenci I., Ozden H., -Apoptotic effects of dipyrido [3,2-a:2 -,3 --c] phenazine (dppz) Au(III) complex against diethylnitrosamine/phenobarbital induced experimental hepatocarcinogenesis in rats-, MOLECULAR BIOLOGY REPORTS, cilt.41, ss.5109-5121, 2014
dc.identifier.doi10.1007/s11033-014-3376-2
dc.identifier.scopus84905121878
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26295
dc.identifier.wosWOS:000339910900026
dc.titleApoptotic effects of dipyrido [3,2-a:2 -,3 --c] phenazine (dppz) Au(III) complex against diethylnitrosamine/phenobarbital induced experimental hepatocarcinogenesis in rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.id8a627095-21bd-417e-8c0d-0f399709af69
local.publication.isinternational1
relation.isAuthorOfPublication7c79666b-9d7a-4020-a3f2-da0a94989b66
relation.isAuthorOfPublication.latestForDiscovery7c79666b-9d7a-4020-a3f2-da0a94989b66
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