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Alpha-Melanocyte-Stimulating Hormone and Agouti-Related Protein: Do They Play a Role in Appetite Regulation in Childhood Obesity?

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dc.contributor.authorVehapoglu, AYSEL
dc.contributor.authorTURKMEN, Serdar
dc.contributor.authorTerzioglu, Sule
dc.contributor.institutionauthorVEHAPOĞLU TÜRKMEN, AYSEL
dc.contributor.institutionauthorTERZİOĞLU, ŞULE
dc.date.accessioned2019-10-05T14:54:50Z
dc.date.available2019-10-05T14:54:50Z
dc.date.issued2016-03-01
dc.description.abstractObjective: The hypothalamus plays a crucial role in the regulation of feeding behavior. The anorexigenic neuropeptide alpha-melanocyte-stimulating hormone (α-MSH) and the orexigenic neuropeptide agouti-related protein (AgRP) are among the major peptides produced in the hypothalamus. This study investigated the plasma concentrations of α-MSH and AgRP in underweight and obese children and their healthy peers. The associations between α-MSH and AgRP levels and anthropometric and nutritional markers of malnutrition and obesity were also assessed. Methods: Healthy sex-matched subjects aged 2 to 12 years were divided into 3 groups, as underweight (n=57), obese (n=61), and of normal weight (n=57). Plasma fasting concentrations of α-MSH and AgRP were measured by enzyme-linked immunosorbent assay. The differences between the three groups as to the relationships between plasma concentrations of α-MSH and AgRP and anthropometric data, serum biochemical parameters and homeostatic model assessment of insulin resistance were evaluated. Results: Obese children had significantly lower α-MSH levels than underweight (1194±865 vs. 1904±1312 ng/mL, p=0.006) and normal weight (1194±865 vs. 1762±1463 ng/mL, p=0.036) children; there were no significant differences in the α-MSH levels between the underweight and normal weight children (p=0.811). Also, no significant differences were observed between the underweight and obese children regarding the AgRP levels (742±352 vs. 828±417 ng/mL, p=0.125). We found a significant positive correlation between plasma α-MSH and AgRP levels across the entire sample. Conclusion: This study is the first to demonstrate body weight-related differences in α-MSH and AgRP levels in children. Circulating plasma α-MSH levels in obese children were markedly lower than those of underweight and normal-weight children. This suggests that α-MSH could play a role in appetite regulation.en
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier10.18231/2393-9834.2018.0027
dc.identifier.citationVehapoglu A., TURKMEN S., Terzioglu S., -Alpha-Melanocyte-Stimulating Hormone and Agouti-Related Protein: Do They Play a Role in Appetite Regulation in Childhood Obesity?-, JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.8, ss.40-47, 2016
dc.identifier.doi10.4274/jcrpe.2136
dc.identifier.pubmed26758700
dc.identifier.scopus84959187073
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/5043
dc.identifier.wosWOS:000378168600006
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleAlpha-Melanocyte-Stimulating Hormone and Agouti-Related Protein: Do They Play a Role in Appetite Regulation in Childhood Obesity?
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJournal of Dental Specialities
local.avesis.id7c574a91-9f02-4056-a0d2-68026b688188
local.avesis.response4913
local.org.facultyTıp Fakültesi
local.publication.goal02 - Açlığa Son
local.publication.isinternational1
relation.isAuthorOfPublicationb68333b8-8b35-4545-989f-bf6e27e7a81b
relation.isAuthorOfPublicatione9c5ccbe-e102-4178-b519-106941fe5827
relation.isAuthorOfPublication.latestForDiscoveryb68333b8-8b35-4545-989f-bf6e27e7a81b
relation.isGoalOfPublication5246edf8-60d4-4a7b-9a27-c73e4a636141
relation.isGoalOfPublication.latestForDiscovery5246edf8-60d4-4a7b-9a27-c73e4a636141
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