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Formulation, stability and analytical method validations of combined St. John-s wort and valerian root dry extracts in solid oral dosage forms

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dc.contributor.authorDemirbolat, Ilker
dc.contributor.authorKARTAL, MURAT
dc.contributor.institutionauthorKARTAL, MURAT
dc.date.accessioned2020-01-13T20:59:37Z
dc.date.available2020-01-13T20:59:37Z
dc.date.issued2019-01-01T00:00:00Z
dc.description.abstractMinor depression and sleep disorders are common problems in modern societies. There are prescription medicines and herbal remedies to ease the symptoms. St. John-s wort is often used to treat mild depression and valerian root is recommended as a sedative for centuries. Nowadays there is an increasing interest for herbal medicines and therefore the herbal products are becoming more and more popular. As dietary supplement retailers selling low quality products -or even don-t contain what-s claimed on the label- quality becomes the major concern. The legislation to conventional medicines applies to traditional herbal medicines too, which makes registered herbal medicines reliable in production and quality. A CTD application dossier which contains quality data in module 3 should be provided while registering a herbal medicine in EU. In this study we developed a stable formulation and validated two separate methods to quantify the herbal extract amounts in solid oral dosage forms which contains St. John-s Wort and valerian dry extract as active ingredients to comply CTD module 3 requirements.
dc.identifier.citationDemirbolat I., KARTAL M., -Formulation, stability and analytical method validations of combined St. John-s wort and valerian root dry extracts in solid oral dosage forms-, JOURNAL OF RESEARCH IN PHARMACY, cilt.23, ss.812-821, 2019
dc.identifier.doi10.35333/jrp.2019.29
dc.identifier.scopus85072920320
dc.identifier.trdizinDOI: https://doi.org/10.35333/jrp.2019.29
dc.identifier.trdizintrdizin
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/12288
dc.identifier.wosWOS:000485773700006
dc.titleFormulation, stability and analytical method validations of combined St. John-s wort and valerian root dry extracts in solid oral dosage forms
dc.typeArticle
dspace.entity.typePublication
local.avesis.idcc460ed5-b3ff-44ab-bc92-c1ec129be5e9
local.publication.isinternational1
relation.isAuthorOfPublicationb30ec030-5f34-4c8b-814e-a7131d524a0a
relation.isAuthorOfPublication.latestForDiscoveryb30ec030-5f34-4c8b-814e-a7131d524a0a
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