Publication:
A New Lipid-Based Nano Formulation of Vinorelbine

Simple item page
dc.contributor.authorBahadori, FATEMEH
dc.contributor.authorTopcu, Gulacti
dc.contributor.authorEROĞLU, MEHMET SAYIP
dc.contributor.authorONYUKSEL, Hayat
dc.contributor.institutionauthorBAHADORİ, FATEMEH
dc.contributor.institutionauthorTOPÇU, GÜLAÇTI
dc.date.accessioned2019-10-05T12:38:37Z
dc.date.available2019-10-05T12:38:37Z
dc.date.issued2014-10-01
dc.description.abstractVinorelbine (VLB) is a semi-synthetic Vinca alkaloid which is currently used in treatment of different cancer types mainly advanced breast cancer (ABC) and advanced/metastatic non-small cell lung cancer (NSCLC). However, its marketed formulation has been reported to have serious side effects, such as granulocytopenia, which is the major dose-limiting toxicity. Other unwanted effects include venous discoloration and phlebitis proximal to the site of injection, as well as localized rashes and urticaria, blistering, and skin sloughing. Our long-term aim in synthesizing a novel nanomicellar vinorelbine formulation is to reduce or even eliminate these side effects and increase drug activity by formulating the drug in a lipid-based system as a nanomedicine targeted to the site of action. To this end, the purpose of this study was to prepare, characterize, and determine the in vitro efficacy of vinorelbine-loaded sterically stabilized, biocompatible, and biodegradable phospholipid nanomicelles (SSM; size, similar to 15 nm). Our results indicated that vinorelbine incorporate at high quantities and within the interface between the core and palisade sections of the micelles. Incorporation ratio of drug within sterically stabilized micelles increased as the total amount of drug in the system increased, and no drug particles were formed at the highest drug concentrations tested. The nanomicellar formulation of vinorelbine was similar to 6.7-fold more potent than vinorelbine dissolved in DMSO on MCF-7 cell line. Collectively, these data indicate that vinorelbine-loaded SSM can be developed as a new, safe, stable, and effective nanomedicine for the treatment of breast and lung cancers.
dc.identifier10.1016/j.jallcom.2010.11.088
dc.identifier.citationBahadori F., Topcu G., EROĞLU M. S. , ONYUKSEL H., -A New Lipid-Based Nano Formulation of Vinorelbine-, AAPS PHARMSCITECH, cilt.15, ss.1138-1148, 2014
dc.identifier.doi10.1208/s12249-014-0146-3
dc.identifier.pubmed
dc.identifier.scopus84907868192
dc.identifier.urihttps://hdl.handle.net/20.500.12645/248
dc.identifier.urihttps://link.springer.com/article/10.1208%2Fs12249-014-0146-3
dc.identifier.wosWOS:000342489200010
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectnano drug delivery
dc.titleA New Lipid-Based Nano Formulation of Vinorelbine
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJOURNAL OF ALLOYS AND COMPOUNDS
local.avesis.id02d81a09-25d5-4979-bc4d-b6a0a7fec29f
local.avesis.response118
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication14c64c63-5d3c-42d0-9f93-cf4b7af6da81
relation.isAuthorOfPublication3c94748e-c303-4294-ad67-c5a0739628e5
relation.isAuthorOfPublication.latestForDiscovery3c94748e-c303-4294-ad67-c5a0739628e5
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
a new lipid.pdf
Size:
1.39 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Yayınlar - Eserler