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Microstructural brain changes in acromegaly: quantitative analysis by diffusion tensor imaging

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dc.contributor.authorKILICARSLAN, R.
dc.contributor.authorILHAN, M. M.
dc.contributor.authorAlkan, ALPAY
dc.contributor.authorARALASMAK, AYŞE
dc.contributor.authorAKKOYUNLU, M. E.
dc.contributor.authorKART, L.
dc.contributor.authorTASAN, ERTUĞRUL
dc.contributor.institutionauthorİLHAN, MAHMUT MUZAFFER
dc.contributor.institutionauthorALKAN, ALPAY
dc.contributor.institutionauthorARALAŞMAK, AYŞE
dc.contributor.institutionauthorTAŞAN, ERTUĞRUL
dc.date.accessioned2019-10-05T13:40:02Z
dc.date.available2019-10-05T13:40:02Z
dc.date.issued2014-06-01
dc.description.abstractObjective: We examined brain diffusion changes of patients with acromegaly. We searched whether there are differences in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values between remission and nonremission patients with acromegaly and investigated any effect of time of hormone exposure on diffusion metrics. Methods: The values of FA and ADC were calculated in a total of 35 patients with acromegaly and 28 control subjects. Patients were subdivided into remission and non-remission groups. We looked at brain FA and ADC differences among the groups and looked for any relation between the diffusion changes and time of hormone exposure among the patients with acromegaly. Results: We found decreased FA and increased ADC values in some of the growth hormone responsive areas. There were no significant brain diffusion changes between remission and non-remission groups. The most affected areas were the hypothalamus, parietal white matter and pre-motor cortex in patients with acromegaly. In terms of hormone exposure time among the patients with acromegaly, there was no effect of disease duration on brain microstructural changes. Conclusion: All patients with acromegaly showed increased brain diffusion with no relation to disease duration and treatment status. We suggested that in patients with acromegaly, brain damage had already occurred in the subclinical period before symptom onset. Advances in knowledge: This study contributes to the understanding of the mechanisms in acromegaly.en
dc.identifier10.14235/bs.2016.682
dc.identifier.citationKILICARSLAN R., ILHAN M. M. , Alkan A., ARALASMAK A., AKKOYUNLU M. E. , KART L., TASAN E., -Microstructural brain changes in acromegaly: quantitative analysis by diffusion tensor imaging-, BRITISH JOURNAL OF RADIOLOGY, cilt.87, 2014
dc.identifier.pubmed24734977
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/2675
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleMicrostructural brain changes in acromegaly: quantitative analysis by diffusion tensor imaging
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameBEZMIALEM SCIENCE
local.avesis.id41745819-73e2-4d5b-b7f6-b51b859ebc42
local.avesis.response2545
local.org.facultyTıp Fakültesi
relation.isAuthorOfPublication03a7dcd2-c33d-41cc-96f8-cb42f0b95200
relation.isAuthorOfPublicationea0f4848-264f-435e-8d73-0f1ca4814d4a
relation.isAuthorOfPublication916dd84c-0db6-43c4-8168-c6c875f27bbe
relation.isAuthorOfPublication6356cfb4-7ab2-4a3d-b37d-263c86174772
relation.isAuthorOfPublication.latestForDiscovery916dd84c-0db6-43c4-8168-c6c875f27bbe
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