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Use of serum and peritoneal CEA and CA19-9 in prediction of peritoneal dissemination and survival of gastric adenocarcinoma patients: are they prognostic factors?

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dc.contributor.authorHASBAHCECI, MUSTAFA
dc.contributor.authorMalya, FATMA ÜMİT
dc.contributor.authorKunduz, ENVER
dc.contributor.authorGuzel, MEHMET
dc.contributor.authorUnver, NURCAN
dc.contributor.authorAkcakaya, ADEM
dc.contributor.institutionauthorMALYA, FATMA ÜMİT
dc.contributor.institutionauthorKUNDUZ, ENVER
dc.contributor.institutionauthorGÜZEL, MEHMET
dc.contributor.institutionauthorÜNVER, NURCAN
dc.contributor.institutionauthorAKÇAKAYA, ADEM
dc.date.accessioned2019-10-05T21:39:35Z
dc.date.available2019-10-05T21:39:35Z
dc.date.issued2018-04-01
dc.description.abstractINTRODUCTION To evaluate the impact of serum and peritoneal levels of tumour markers on peritoneal carcinomatosis and survival in gastric adenocarcinoma. MATERIALS AND METHODS Patients with gastric adenocarcinoma were evaluated with regard to serum and peritoneal carcinoembryonic antigen (CEA) and CA19-9. Numeric values and groupings based on serum and peritoneal cutoff values were used. Development of peritoneal carcinomatosis, including positive washing cytology, was regarded as main outcome. Gastric cancer outcomes as disease free and overall survival were analysed. RESULTS There were 67 patients with a mean age of 60 ± 11 years. Positive peritoneal washing cytology was significantly associated with serum CA19-9 and high serum CA 19–9 group (P = 0.033 and P = 0.011, respectively). High peritoneal CEA was shown to be significantly associated with peritoneal carcinomatosis (P = 0.032). After a median follow up of 17 months, 48 patients (71.7%) were alive. Patients with peritoneal carcinomatosis showed significant poorer prognosis as shown by overall survival rate of 28.6%. Only serum CEA was significantly associated with lower disease free and overall survival (P = 0.002 and P = 0.001, respectively). DISCUSSION AND CONCLUSION Serum CEA is shown to be significantly associated with poor prognosis for gastric cancer patients. Serum level of CA19-9 and high peritoneal CEA levels are significant predictors for positive peritoneal washing cytology and the development of peritoneal carcinomatosis, respectively. Therefore, the possible impact of serum and peritoneal tumor markers especially on the staging and prognosis of gastric cancer remains to be clarified by future studies.en
dc.identifier10.21470/1678-9741-2017-0236
dc.identifier.citationHASBAHCECI M., Malya F. Ü. , Kunduz E., Guzel M., Unver N., Akcakaya A., -Use of serum and peritoneal CEA and CA19-9 in prediction of peritoneal dissemination and survival of gastric adenocarcinoma patients: are they prognostic factors?-, Annals of the Royal College of Surgeons of England, cilt.100, ss.257-266, 2018
dc.identifier.doi10.1308/rcsann.2018.0011
dc.identifier.pubmed29543051
dc.identifier.scopus85044502762
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7879
dc.identifier.wosWOS:000433059000012
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleUse of serum and peritoneal CEA and CA19-9 in prediction of peritoneal dissemination and survival of gastric adenocarcinoma patients: are they prognostic factors?
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameBRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
local.avesis.idc3ed6643-2f10-4dc6-94ee-bc0933a0ea08
local.avesis.response7755
local.publication.isinternational1
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relation.isAuthorOfPublicationc1643dec-92f7-407b-b007-9d8e0caea111
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relation.isAuthorOfPublication.latestForDiscovery0af18f13-53ee-4cbb-a171-30d8b1f8126e
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