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Quercus pyrenaica Honeydew Honey With High Phenolic Contents Cause DNA Damage, Apoptosis, and Cell Death Through Generation of Reactive Oxygen Species in Gastric Adenocarcinoma Cells

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dc.contributor.authorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.authorAydogdu, Gokhan
dc.contributor.authorBALKAN, EZGİ
dc.contributor.authorGÜLER, Eray Metin
dc.contributor.authorBULUT, HURİ
dc.contributor.authorKÖKTAŞOĞLU, FATMANUR
dc.contributor.authorGoeren, AHMET CEYHAN
dc.contributor.authorAtayoglu, Ali Timucin
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorBALKAN, EZGİ
dc.contributor.institutionauthorYENİGÜN, VILDAN BETÜL
dc.contributor.institutionauthorGÜLER, ERAY METİN
dc.contributor.institutionauthorBULUT, HURI
dc.contributor.institutionauthorKÖKTAŞOĞLU, FATMANUR
dc.contributor.institutionauthorGÖREN, AHMET CEYHAN
dc.date.accessioned2019-11-03T22:42:09Z
dc.date.available2019-11-03T22:42:09Z
dc.date.issued2019-09-01
dc.description.abstractMany studies have shown that honey with high phenolic contents prevents cancer formation. Furthermore, recent studies have demonstrated that honey can be used for the treatment of cancer as well as cancer prevention. Antineoplastic effects of honey are often associated with their antioxidant phenolic contents. However, very few studies have dealt with the association of phenolic contents of honeys in terms of antiproliferative effects. The aim of this study was, therefore, to elucidate the cytotoxic, genotoxic, apoptotic, and reactive oxygen species (ROS) generating effects of honey samples on the basis of their phenolic and flavonoid contents. Fourteen different honey varieties were collected from various parts of Turkey, and their characteristics regarding total phenols, flavonoids, and antioxidant contents were determined to test their effects on gastric cancer cells (AGS). For convenience, 2 honey varieties were selected, namely, Ida Mountains Quercus pyrenaica honeydew honey (QPHH-IM) having the highest phenolic and antioxidant content and Canakkale multifloral honey (MFH-C) with the lowest phenolic and antioxidant content. Levels of 11 different phenolic compounds in QPHH-IM and MFH-C samples were determined by LC-MS/MS. AGS cells were incubated with different concentrations of QPHH-IM and MFH-C for 24 hours, then the cell viability, DNA damage, apoptosis, and generation of ROS were determined. We found that QPHH-IM had more cytotoxic, genotoxic, and apoptotic effects than that of MFH-C. We think that these effects are probably related to pro-oxidant activities due to the high phenolic contents present. Therefore, further research on high-phenolic honey may contribute to the future development of cancer therapeutics.en
dc.identifier.citationKOÇYİĞİT A., Aydogdu G., BALKAN E., Yenigun V. B. , GÜLER E. M. , BULUT H., KÖKTAŞOĞLU F., Goeren A. C. , Atayoglu A. T. , -Quercus pyrenaica Honeydew Honey With High Phenolic Contents Cause DNA Damage, Apoptosis, and Cell Death Through Generation of Reactive Oxygen Species in Gastric Adenocarcinoma Cells-, INTEGRATIVE CANCER THERAPIES, cilt.18, 2019
dc.identifier.doi10.1177/1534735419876334
dc.identifier.pubmed31556752
dc.identifier.scopus85072664818
dc.identifier.urihttps://hdl.handle.net/20.500.12645/10258
dc.identifier.wosWOS:000487957900001
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleQuercus pyrenaica Honeydew Honey With High Phenolic Contents Cause DNA Damage, Apoptosis, and Cell Death Through Generation of Reactive Oxygen Species in Gastric Adenocarcinoma Cells
dc.typeArticle
dspace.entity.typePublication
local.avesis.id4c5f1ea0-f2dd-45cf-8ba3-eac203615644
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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