Publication:
Correlation between apnea-hypopnea index and Tp-Te interval, Tp-Te/QT, and Tp-Te/QTc ratios in obstructive sleep apnea

Simple item page
dc.contributor.authorKARAÇÖP, ERDEM
dc.contributor.authorKaracop, Handan B.
dc.contributor.institutionauthorKARAÇÖP, ERDEM
dc.date.accessioned2021-02-03T20:59:09Z
dc.date.available2021-02-03T20:59:09Z
dc.date.issued2020-10-01T00:00:00Z
dc.description.abstractBackground Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder associated with important cardiovascular complications including ventricular arrhythmias. Tp-Te interval, Tp-Te/QT, and Tp-Te/QTc ratios are repolarization indices representing ventricular arrhythmogenic potential. These parameters are associated with ventricular arrhythmias and sudden cardiac death. The aim of this study was to investigate the correlation between apnea-hypopnea index and Tp-Te, Tp-Te/QT, and Tp-Te/QTc in OSA. Methods We screened a total of 280 patients who underwent overnight polysomnography (PSG) between the years 2012-2017 at our institution. Patients were assigned into four groups based on severity of apnea-hypopnea index: 70 with apnea-hypopnea index (AHI) = 30. Tp-Te, Tp-Te/QT, and Tp-Te/QTc were measured. Results Compared to control group, repolarization parameters were significantly prolonged in other groups (Tp-Te interval: 68.3 +/- 6.8, 71.8 +/- 6.3, 79.1 +/- 5.5, and 85.1 +/- 6.4 ms,p < .001; Tp-Te/QT ratio: 167.5 +/- 12.7, 181.7 +/- 13.0, 202.2 +/- 10.0 and 219.4 +/- 13.5,p < .001; Tp-Te/QTc ratio: 151.1 +/- 16.6, 167.6 +/- 16.6, 193.7 +/- 14.4, and 225.5 +/- 17.0,p < .001). There was a significant trend toward higher Tp-Te, Tp-Te/QT, and Tp-Te/QTc across higher AHI categories. In a univariate regression analysis, body mass index, smoking status, Tp-Te, and Tp-Te/QTc were significantly associated with the severity of AHI in OSA. Tp-Te (OR 1.629, 95% CI 1.393-1.906,p < .001), Tp-Te/QTc (OR 1,333 95% CI 1.247-1.424,p < .001), and smoking status (OR 5.771, 95% CI 1.025-32.479,p = .047) were found to be significant independent predictors of severity of AHI in a multivariate analysis, after adjusting for other risk parameters. Conclusions Our study showed that Tp-Te, Tp-Te/QT, and Tp-Te/QTc were prolonged in patients with OSA. There was significant correlation between apnea-hypopnea index and these parameters.
dc.identifier.citationKARAÇÖP E., Karacop H. B. , -Correlation between apnea-hypopnea index and Tp-Te interval, Tp-Te/QT, and Tp-Te/QTc ratios in obstructive sleep apnea-, ANNALS OF NONINVASIVE ELECTROCARDIOLOGY, 2020
dc.identifier.doi10.1111/anec.12809
dc.identifier.pubmed33064338
dc.identifier.scopus85092555598
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28284
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/anec.12809
dc.identifier.wosWOS:000577625800001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectobstructive sleep apnea (OSA)
dc.subjectTp-Te interval
dc.subjectQT and Tp-Te
dc.subjectQTc ratios
dc.subjectTp-Te
dc.titleCorrelation between apnea-hypopnea index and Tp-Te interval, Tp-Te/QT, and Tp-Te/QTc ratios in obstructive sleep apnea
dc.typeArticle
dspace.entity.typePublication
local.avesis.id99d8a906-5d3b-4f8e-b357-5a29915ff898
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublicationd764645a-8974-46cc-b839-17dc2938c958
relation.isAuthorOfPublication.latestForDiscoveryd764645a-8974-46cc-b839-17dc2938c958
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Correlation between apnea-hypopnea index and Tp-Te interval, Tp-TeQT, and Tp-TeQTc ratios in obstructive sleep apnea.pdf
Size:
682.08 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Yayınlar - Eserler