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Radiation-Induced Meningiomas: A Series of Four Consecutive Patients and a Review of Literature

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dc.contributor.authorABDALLAH, ANAS ABDELRAHIM SA
dc.contributor.authorGÜNDÜZ, Hasan Burak
dc.contributor.authorEMEL, Erhan
dc.contributor.authorASİLTÜRK, Murad
dc.contributor.authorSofuoğlu, Özden Erhan
dc.contributor.authorBİLGİÇ, Bilge
dc.contributor.authorGÜLER ABDALLAH, Betül
dc.contributor.institutionauthorABDALLAH, ANAS ABDELRAHıM SA
dc.date.accessioned2019-10-05T14:52:36Z
dc.date.available2019-10-05T14:52:36Z
dc.date.issued2018-01-01
dc.description.abstractAIM: To assess the clinical outcomes of treatment for radiation-induced meningiomas. MATERIAL and METHODS: Medical records were retrospectively reviewed for all cranial meningioma cases that were diagnosed and/or underwent surgery at our hospital from 2009 to 2016. All radiation-associated meningioma patients constituted the core sample for this study. RESULTS: This series included one female and three male patients, with a mean age of 47.3 ± 16.3 years. The mean preoperative course was <3 months. The most common symptom was headache (100%) and three patients had alopecia and thin scalp skin. The mean of the age at which they underwent radiotherapy was 18.5 ± 13.7 years. The mean latency period was 19.2 ± 7.4 years. Initial malignancies included two patients with desmoplastic medulloblastomas (13-year-old female, 65 Gy), (11-year-old male, 54 Gy) and a patient with grade II oligodendroglioma treated with 30 Gy. A male patient received low-dose radiotherapy for chronic otitis at 10 years old. Histopathological examinations revealed the following: 1) fibroblastic-grade I, Ki-67 2%–3%, 25.5 years latency; cerebellopontine angle, 2) atypical meningioma grade II, Ki-67 8%, 21 years, frontal; and 3) transitional grade I, Ki-67 3%–4%, 11 years, frontal. The fourth patient had three radiation-induced meningiomas and 27 radiation-induced cavernomas, and was treated using a gamma knife. The mean follow-up period was 34.8±39.4 months. One patient had rhinorrhea and another experienced a cerebrospinal fluid fistula. Both underwent an additional operation. The former died because of meningitis on postoperative day 31. CONCLUSION: Most radiation-induced meningiomas are low-grade, but they have a high trend of recurrence. Close follow-up and yearly magnetic resonance imaging would minimize the morbidity rate. To reduce fatal complications, surgery should be planned in conjunction with plastic surgeons.en
dc.identifier10.1002/slct.201801578
dc.identifier.citationABDALLAH A. A. S. , GÜNDÜZ H. B. , ASİLTÜRK M., Sofuoğlu Ö. E. , BİLGİÇ B., EMEL E., GÜLER ABDALLAH B., -Radiation-Induced Meningiomas: A Series of Four Consecutive Patients and a Review of Literature-, TURKISH NEUROSURGERY, cilt.28, ss.1-27, 2018
dc.identifier.trdizinDOI: https://doi.org/10.5137/1019-5149.JTN.21197-17.2
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4936
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleRadiation-Induced Meningiomas: A Series of Four Consecutive Patients and a Review of Literature
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameCHEMISTRYSELECT
local.avesis.id795f12fe-5fa2-4071-a396-85b4929c3b61
local.avesis.response4806
local.publication.isinternational1
relation.isAuthorOfPublicationf9c054d8-61e2-4c78-a736-c2cbd02ee875
relation.isAuthorOfPublication.latestForDiscoveryf9c054d8-61e2-4c78-a736-c2cbd02ee875
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