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Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.)

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dc.contributor.authorTopal, Meryem
dc.contributor.authorGocer, Hulya
dc.contributor.authorTopal, Fevzi
dc.contributor.authorKalin, Pinar
dc.contributor.authorKose, Leyla Polat
dc.contributor.authorGÜLÇİN, İlhami
dc.contributor.authorCakmak, Kader C.
dc.contributor.authorKucuk, Murat
dc.contributor.authorDurmaz, Lokman
dc.contributor.authorGoren, AHMET CEYHAN
dc.contributor.authorALWASEL, Saleh H.
dc.contributor.institutionauthorGÖREN, AHMET CEYHAN
dc.date.accessioned2020-10-30T00:16:52Z
dc.date.available2020-10-30T00:16:52Z
dc.date.issued2016-03-03T00:00:00Z
dc.description.abstractCynarin is a derivative of hydroxycinnamic acid and it has biologically active functional groups constituent of some plants and food. We elucidated the antioxidant activity of cynarin by using different in vitro condition bioanalytical antioxidant assays like DMPD center dot+, ABTS(center dot+), O-2(center dot-), DPPH center dot and H2O2 scavenging effects, the total antioxidant influence, reducing capabilities, Fe2+ chelating and anticholinergic activities. Cynarin demonstrated 87.72% inhibition of linoleic acid lipid peroxidation at 30 mu g/mL concentration. Conversely, some standard antioxidants like trolox, -tocopherol, butylated hydroxytoluene (BHT), and butylated hydroxyanisole (BHA) exhibited inhibitions of 90.32, 75.26, 97.61, 87.30%, and opponent peroxidation of linoleic acid emulsion at the identical concentration, seriatim. Also, cynarin exhibited effective DMPD center dot+, ABTS(center dot+), O-2(center dot-), DPPH center dot, and H2O2 scavenging effects, reducing capabilities and Fe2+ chelating effects. On the contrary, IC50 and K-i parameters of cynarin for acetylcholinesterase enzyme inhibition were determined as 243.67 nM (r(2): 0.9444) and 39.34 +/- 13.88 nM, respectively. This study clearly showed that cynarin had marked antioxidant, anticholinergic, reducing ability, radical-scavenging, and metal-binding activities.
dc.identifier.citationTopal M., Gocer H., Topal F., Kalin P., Kose L. P. , GÜLÇİN İ., Cakmak K. C. , Kucuk M., Durmaz L., Goren A. C. , et al., -Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.)-, JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.31, ss.266-275, 2016
dc.identifier.doi10.3109/14756366.2015.1018244
dc.identifier.scopus84955507480
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27161
dc.identifier.wosWOS:000368719800011
dc.titleAntioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.)
dc.typeArticle
dspace.entity.typePublication
local.avesis.idf0386475-7ea6-4955-a33b-635b88e73bf0
local.publication.isinternational1
relation.isAuthorOfPublication07fcea81-8515-4cd4-86f2-047fe6b2df71
relation.isAuthorOfPublication.latestForDiscovery07fcea81-8515-4cd4-86f2-047fe6b2df71
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