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MR spectroscopy features of brain in patients with mild and severe obstructive sleep apnea syndrome

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dc.contributor.authorAlkan, ALPAY
dc.contributor.authorSHARIFOV, Resul
dc.contributor.authorAkkoyunlu, MUHAMMED EMİN
dc.contributor.authorKILICARSLAN, Rukiye
dc.contributor.authorToprak, HÜSEYİN
dc.contributor.authorAralasmak, AYŞE
dc.contributor.authorKART, Levent
dc.contributor.institutionauthorALKAN, ALPAY
dc.contributor.institutionauthorAKKOYUNLU, MUHAMMED EMİN
dc.contributor.institutionauthorTOPRAK, HÜSEYİN
dc.contributor.institutionauthorARALAŞMAK, AYŞE
dc.date.accessioned2019-10-05T21:26:20Z
dc.date.available2019-10-05T21:26:20Z
dc.date.issued2013-11-01
dc.description.abstractPurpose: We investigated whether there are differences in metabolite ratios of different brain regions between mild and severe obstructive sleep apnea (OSA) patients. Materials and methods: A total of 17 mild OSA and 14 severe OSA patients were enrolled. N-acetyl aspartate (NAA)/creatine (Cr), choline (Cho)/Cr and NAA/Cho ratios were calculated by using multivoxel magnetic resonance spectroscopy (MRS) (TR: 1500, TE: 135 ms) from hippocampus, putamen, insular cortex, thalamus and temporal white matter. The relationship between the two groups was evaluated with Mann-Whitney U test Results: NAA/Cr ratios obtained from hippocampus was found to be significantly increased in severe OSA patients compared to mild OSA patients (P=.004). Cho/Cr ratios obtained from hippocampus and putamen in severe OSA patients were significantly increased when compared to mild OSA patients (P=.003 and P=.004, respectively). In addition, NAA/Cho ratios of putamen were significantly decreased in severe OSA patients when compared to mild OSA (P=.032). Conclusion: MRS identified hypoxia-related metabolite and microstructural changes in hippocampus and putamen. The metabolite changes of increase in NAA/Cr and Cho/Cr ratios and decrease in NAA/Cho ratio were more pronounced with increasing severity of OSA syndrome. (C) 2013 Elsevier Inc. All rights reserved.
dc.identifier
dc.identifier.citationAlkan A., SHARIFOV R., Akkoyunlu M. E. , KILICARSLAN R., Toprak H., Aralasmak A., KART L., -MR spectroscopy features of brain in patients with mild and severe obstructive sleep apnea syndrome-, CLINICAL IMAGING, cilt.37, ss.989-992, 2013
dc.identifier.pubmed23993754
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7299
dc.language.isoen
dc.titleMR spectroscopy features of brain in patients with mild and severe obstructive sleep apnea syndrome
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJOURNAL OF NEPHROLOGY
local.avesis.idb5e166c2-bd0c-45f1-abe2-2ef191f364f0
local.avesis.response7175
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relation.isAuthorOfPublication.latestForDiscovery916dd84c-0db6-43c4-8168-c6c875f27bbe
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