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The efficacy and safety of influenza vaccination in older people: An umbrella review of evidence from meta-analyses of both observational and randomized controlled studies

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dc.contributor.authorDemurtas, Jacopo
dc.contributor.authorCelotto, Stefano
dc.contributor.authorBeaudart, Charlotte
dc.contributor.authorSanchez-Rodriguez, Dolores
dc.contributor.authorBalci, Cafer
dc.contributor.authorSOYSAL, PINAR
dc.contributor.authorSolmi, Marco
dc.contributor.authorCelotto, Daniele
dc.contributor.authorRighi, Elena
dc.contributor.authorSmith, Lee
dc.contributor.authorLopalco, Pier Luigi
dc.contributor.authorNoventa, Vania
dc.contributor.authorMichel, Jean Pierre
dc.contributor.authorTorbahn, Gabriel
dc.contributor.authorDi Gennaro, Francesco
dc.contributor.authorPizzol, Damiano
dc.contributor.authorVeronese, Nicola
dc.contributor.authorMaggi, Stefania
dc.contributor.institutionauthorSOYSAL, PINAR
dc.date.accessioned2020-10-22T15:54:04Z
dc.date.available2020-10-22T15:54:04Z
dc.date.issued2020-09-01T00:00:00Z
dc.description.abstractVaccination is the main public health intervention to prevent influenza. We aimed to evaluate the efficacy and safety of influenza vaccination including systematic reviews and meta-analyses of observational studies and randomized controlled trials (RCTs). Peer-reviewed systematic reviews with meta-analyses of prospective studies that investigated the association of influenza vaccination with any health-related outcome, as well as RCTs that investigated the efficacy and safety of influenza vaccination, were included. Among 1240 references, 6 meta-analyses were included. In cohort studies of community-dwelling older people influenza vaccination was associated with a lower risk of hospitalization for heart disease and for influenza/pneumonia (strength of evidence: convincing). Evidence in lowering the risk of mortality in community-dwelling older people, of all deaths/severe respiratory diseases in high risk community-dwelling older people and of hospitalization for influenza/pneumonia in case-control studies, was highly suggestive. In RCTs, influenza vaccination, compared to placebo/no intervention, was associated to higher risk of local tenderness/sore arm and to a reduced risk of influenza like-illness. Both these associations showed moderate evidence using the GRADE (Grading of Recommendations Assessment, Development and Evaluation). In conclusion, influenza vaccination in older people seems safe and effective. Further, the evidence on safety and efficacy of vaccines in this population might benefit by an extension of the follow-up period both in RCTs and in longitudinal studies, beyond the usual 6-month period, in order to be able to evaluate the impact of vaccination on long term outcomes.
dc.identifier.citationDemurtas J., Celotto S., Beaudart C., Sanchez-Rodriguez D., Balci C., SOYSAL P., Solmi M., Celotto D., Righi E., Smith L., et al., -The efficacy and safety of influenza vaccination in older people: An umbrella review of evidence from meta-analyses of both observational and randomized controlled studies-, AGEING RESEARCH REVIEWS, cilt.62, 2020
dc.identifier.doi10.1016/j.arr.2020.101118
dc.identifier.pubmed32565328
dc.identifier.scopus85086783314
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23603
dc.identifier.wosWOS:000571829300012
dc.titleThe efficacy and safety of influenza vaccination in older people: An umbrella review of evidence from meta-analyses of both observational and randomized controlled studies
dc.typeArticle
dspace.entity.typePublication
local.avesis.id45148ad5-378a-44b2-8ff1-7d510672b85f
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication0e36986e-d71d-4579-a395-877af097ade5
relation.isAuthorOfPublication.latestForDiscovery0e36986e-d71d-4579-a395-877af097ade5
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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