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Petroselinum Crispum is Effective in Reducing Stress-Induced Gastric Oxidative Damage.

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dc.contributor.authorAKıNCı, Ayşin
dc.contributor.authorEşrefoğlu, MUKADDES
dc.contributor.authorTASLIDERE, ELİF
dc.contributor.authorATES, B
dc.contributor.institutionauthorEŞREFOĞLU, MUKADDES
dc.contributor.institutionauthorTAŞLIDERE, ELİF
dc.date.accessioned2019-10-05T21:48:35Z
dc.date.available2019-10-05T21:48:35Z
dc.date.issued2017-01-01
dc.description.abstractBackground: Oxidative stress has been shown to play a principal role in the pathogenesis of stress-induced gastric injury. Parsley (Petroselinum crispum) contains many antioxidants such as flavanoids, carotenoids and ascorbic acid. Aims: In this study, the histopathological and biochemical results of nutrition with a parsley-rich diet in terms of eliminating stress-induced oxidative gastric injury were evaluated. Study design: Animal experimentation. Methods: Forty male Wistar albino rats were divided into five groups: control, stress, stress + standard diet, stress + parsley-added diet and stress + lansoprazole (LPZ) groups. Subjects were exposed to 72 hours of fasting and later immobilized and exposed to the cold at +4 degrees for 8 hours to create a severe stress condition. Samples from the animals' stomachs were arranged for microscopic and biochemical examinations. Results: Gastric mucosal injury was obvious in rats exposed to stress. The histopathologic damage score of the stress group (7.00±0.57) was higher than that of the control group (1.50±0.22) (p<0.05). Significant differences in histopathologic damage score were found between the stress and stress + parsley-added diet groups (p<0.05), the stress and stress + standard diet groups (p<0.05), and the stress and stress + LPZ groups (p<0.05). The mean tissue malondialdehyde levels of the stress + parsley-added group and the stress + LPZ group were lower than that of the stress group (p<0.05). Parsley supported the cellular antioxidant system by increasing the mean tissue glutathione level (53.31±9.50) and superoxide dismutase (15.18±1.05) and catalase (16.68±2.29) activities. Conclusion: Oral administration of parsley is effective in reducing stress-induced gastric injury by supporting the cellular antioxidant defence system.en
dc.identifier
dc.identifier.citationAKıNCı A., Eşrefoğlu M., TASLIDERE E., ATES B., -Petroselinum Crispum is Effective in Reducing Stress-Induced Gastric Oxidative Damage.-, Balkan medical journal, cilt.34, ss.53-59, 2017
dc.identifier.doi10.4274/balkanmedj.2015.1411
dc.identifier.pubmed28251024
dc.identifier.scopus85013847954
dc.identifier.trdizinISSN: 2146-3123 / 2146-3131
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/8181
dc.identifier.wosWOS:000396361900008
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titlePetroselinum Crispum is Effective in Reducing Stress-Induced Gastric Oxidative Damage.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTURKIYE KLINIKLERI TIP BILIMLERI DERGISI
local.avesis.idcbbf9bde-12be-40bb-b441-7879243141ed
local.avesis.response8057
local.publication.isinternational1
relation.isAuthorOfPublicationd0c7c343-3b7d-47ef-a2a7-5169234110eb
relation.isAuthorOfPublication1bcd2ccf-c1aa-4999-a863-1d634b1c7fe6
relation.isAuthorOfPublication.latestForDiscovery1bcd2ccf-c1aa-4999-a863-1d634b1c7fe6
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