Publication: Effects of ceftriaxone on ischemia/reperfusion injury in rat brain
No Thumbnail Available
Date
2013-03-01T00:00:00Z
Authors
Authors
Altas, M.
Meydan, SEDAT
Aras, M.
Yilmaz, N.
Ulutas, K. T.
Okuyan, H. M.
Nacar, A.
Journal Title
Journal ISSN
Volume Title
Publisher
Metrics
Abstract
The aim of this study was to investigate the effect of ceftriaxone treatment against short-term global brain ischemia/reperfusion (I/R) injury in rats. The study was carried out on 30 Wistar-albino rats that were divided into three groups: control group (n = 10), I/R group (n = 10) and I/R-ceftriaxone group (n = 10). Malondialdehyde (MDA) levels were significantly increased in the I/R group in comparison with the control group (p < 0.001). MDA was significantly lower in the I/R-ceftriaxone group than in the I/R group (p < 0.05). Superoxide dismutase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the control group. Glutathione peroxidase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the I/R group and the control. Histopathologically, ceftriaxone provided morphological improvement compared with the I/R group. We concluded that ceftriaxone has neuron-protective effects due to its antioxidant properties as shown by a decrease in MDA overproduction and histological improvement in brain tissue. (C) 2012 Elsevier Ltd. All rights reserved.
Description
Keywords
Citation
Altas M., Meydan S., Aras M., Yilmaz N., Ulutas K. T. , Okuyan H. M. , Nacar A., -Effects of ceftriaxone on ischemia/reperfusion injury in rat brain-, JOURNAL OF CLINICAL NEUROSCIENCE, cilt.20, ss.457-461, 2013