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Rutin laboratuar parametreleri, ilaç tedavileri ve cinsiyetin akut kalp yetmezliğinde görülen anemi ile ilişkisi / Routine laboratory parameters, medications and sex related with anaemia in acute heart failure

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dc.contributor.advisorYRD. DOÇ. MEHMET ALİ ÇIKRIKÇIOĞLU
dc.contributor.authorDİKERDEM, Diğdem
dc.date.accessioned2020-11-04T07:19:46Z
dc.date.available2020-11-04T07:19:46Z
dc.date.issued2011
dc.descriptionThesis (Medical)--Bezmialem Vakıf University, Faculty of Medicine, Department of Internal Medicine, Istanbul, 2011.tr_TR
dc.description.abstractObjective: To investigate the relation of medication and routine laboratory parameters with anaemia in acute heart failure (AHF).Method: 234 AHF patients were enrolled in the study. Those with comorbidities leading to anaemia, and those receiving blood transfusion and antianaemic treatment were excluded. Anaemic and non-anaemic AHF patients were compared in terms of demographics, medication use for 3 months prior to hospitalisation, transthoracic echocardiography, haemogram, sCRP, erythrocyte sedimentation rate, proBNP, d-dimer and biochemistry analyses. In addition, haemosiderinuria, reticulocyte count and direct Coombs test were performed in randomly selected 50 patients among the participants. All variables that were found to be significantly different between the anaemic and non-anaemic group were subjected to binary logistic regression analysis (BLRA).Results: The results of BLRA showed that anaemia was seen 4.2 folds less in digoxin users; whereas it was increased in patients have the following conditions by the number of folds indicated in parenthesis: female gender (2.6 folds), calcium channel blocker (CCB) use (2.6), chronic renal failure (3.1), lower serum AST (3.6), lower corrected serum calcium (3), lower LDL cholesterol (2.6), lower mean corpuscular volume (MCV) (2.5), lower mean corpuscular hemoglobin concentration (MCHC) (2.5), higher magnesemia (2.6), higher proBNP (3.5 folds). Haemosiderinuria was positive in 13 patients and was insignificantly more frequent in the anaemic group.Conclusion: Digoxin use, CCB use, lower corrected calcium, higher magnesemia, lower serum AST and lower LDL cholesterol are parameters emerging in our study associated with anaemia in AHF and which have not been reported so far. The contribution of chronic intravascular haemolysis to anaemia might also deserve to be investigated.tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27299
dc.language.isotrtr_TR
dc.publisherBezmialem Vakıf Universitytr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectİç Hastalıkları Anabilim Dalıtr_TR
dc.subjectDepartment of Internal Medicinetr_TR
dc.subjectHematoloji = Hematologytr_TR
dc.subjectKardiyoloji = Cardiologytr_TR
dc.subjectAnemi = Anemiatr_TR
dc.titleRutin laboratuar parametreleri, ilaç tedavileri ve cinsiyetin akut kalp yetmezliğinde görülen anemi ile ilişkisi / Routine laboratory parameters, medications and sex related with anaemia in acute heart failuretr_TR
dc.typeThesistr_TR
dc.typeThesis
dspace.entity.typePublication
local.thesis.programnameDepartment of Internal Medicine
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