Publication:
High performance liquid chromatographic analysis of lercanidipine in human breast milk

Simple item page
dc.contributor.authorTekkeli, Evrim Kepekci
dc.contributor.authorGAZİOĞLU, IŞIL
dc.contributor.authorTIRIS, GİZEM
dc.contributor.authorOnal, Cem
dc.contributor.institutionauthorTEKKELİ, ŞERİFE EVRİM
dc.contributor.institutionauthorGAZİOĞLU, IŞIL
dc.contributor.institutionauthorTIRIS, GİZEM
dc.date.accessioned2019-10-05T21:29:35Z
dc.date.available2019-10-05T21:29:35Z
dc.date.issued2019-01-01
dc.description.abstractA simple, rapid, precise and accurate isocratic reversed phase HPLC method was developed and validated for the determination of lercanidipine hydrochloride in pharmaceutical tablets and spiked human breast milk. The chromatographic separation was achieved on C18 (250x4.6 mmx5 mu m) column using a mobile phase consisting of acetonitrile and phospate buffer (pH=4) (55:45, v/v) at a flow rate of 1.1 mL/min and UV detection at 237 nm. The linearity of the proposed method was investigated in the range of 1.0-40 mu g/mL (r(2)=0.9990). The method was validated in terms of accuracy, precision, reproducibility, specificity, robustness, and detection and quantification limits, in accordance with ICH guidelines. The proposed method is found as suitable for routine quantification of lercanidipine in human breast milk.
dc.identifier
dc.identifier.citationTekkeli E. K. , GAZİOĞLU I., TIRIS G., Onal C., -High performance liquid chromatographic analysis of lercanidipine in human breast milk-, JOURNAL OF CHEMICAL METROLOGY, cilt.13, ss.1-6, 2019
dc.identifier.doi10.25135/jcm.23.19.03.1223
dc.identifier.trdizinISSN: 1307-6183
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7436
dc.identifier.wosWOS:000472604800001
dc.language.isoen
dc.titleHigh performance liquid chromatographic analysis of lercanidipine in human breast milk
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameRHINOLOGY
local.avesis.idb921659d-9779-4315-88b1-dff9f56486ac
local.avesis.response7312
local.publication.isinternational1
relation.isAuthorOfPublication837d5047-762e-43db-b252-9f3d1399378f
relation.isAuthorOfPublication336380d2-70ee-496d-a002-08059f9da500
relation.isAuthorOfPublication1ab47475-d54a-4b46-a679-47fb775bc1ce
relation.isAuthorOfPublication.latestForDiscovery336380d2-70ee-496d-a002-08059f9da500
Files
Collections
Yayınlar - Eserler
Eczacılık Fakültesi
TR Dizin İndeksli Yayınlar Koleksiyonu