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SIRT1 gene variants are related to risk of childhood obesity

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dc.contributor.authorKilic, Ulkan
dc.contributor.authorGOK, Ozlem
dc.contributor.authorELIBOL-CAN, BİRSEN
dc.contributor.authorOzgen, Ilker Tolga
dc.contributor.authorErenberk, UFUK
dc.contributor.authorUysal, Omer
dc.contributor.authorDUNDAROZ, Mehmet Rusen
dc.contributor.institutionauthorELİBOL, BİRSEN
dc.contributor.institutionauthorÖZGEN, İLKER TOLGA
dc.contributor.institutionauthorERENBERK, UFUK
dc.contributor.institutionauthorUYSAL, ÖMER
dc.date.accessioned2019-10-05T23:18:42Z
dc.date.available2019-10-05T23:18:42Z
dc.date.issued2015-04-01
dc.description.abstractObesity is a multifactorial disorder resulting from the interaction between genetic, psychological, physical, environmental, and socioeconomic factors. SIRT1 gene has important effects on the regulation of adiponectin, caloric restriction, insulin sensitivity, coronary atherosclerosis, and cardiovascular diseases. The aim of this study was to investigate the association between childhood obesity and SIRT1 gene polymorphisms regarding rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5 using PCR-CTPP method in 120 obese and 120 normal weight children. In this study, BMI, systolic and diastolic blood pressure, LDL cholesterol, triglyceride, and insulin levels were significantly higher and HDL-cholesterol levels were significantly lower in obese children compared to normal weight children. For rs7895833 A > G, the rate of having AG genotype and G allele was significantly higher in obese children compared to non-obese group (p T. There was no significant difference for rs7069102 C > G gene polymorphism between groups.
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier
dc.identifier.citationKilic U., GOK O., ELIBOL-CAN B., Ozgen I. T. , Erenberk U., Uysal O., DUNDAROZ M. R. , -SIRT1 gene variants are related to risk of childhood obesity-, EUROPEAN JOURNAL OF PEDIATRICS, cilt.174, ss.473-479, 2015
dc.identifier.doi10.1007/s00431-014-2424-1
dc.identifier.pubmed25233986
dc.identifier.scopus84925490770
dc.identifier.urihttps://hdl.handle.net/20.500.12645/9970
dc.identifier.wosWOS:000351515300008
dc.language.isoen
dc.titleSIRT1 gene variants are related to risk of childhood obesity
dc.typeArticle
dspace.entity.typePublication
local.article.journalnamePanacea Journal of Pharmacy and Pharmaceutical Sciences
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local.publication.goal01 - Yoksulluğa Son
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