Publication:
The effect of the SIRT1 2827 A > G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease

Simple item page
dc.contributor.authorIZMIRLI, Muzeyyen
dc.contributor.authorGOKTEKIN, Omer
dc.contributor.authorBacaksiz, AHMET
dc.contributor.authorUysal, Omer
dc.contributor.authorKilic, Ulkan
dc.contributor.institutionauthorBACAKSIZ, AHMET
dc.contributor.institutionauthorUYSAL, ÖMER
dc.date.accessioned2019-10-05T21:25:48Z
dc.date.available2019-10-05T21:25:48Z
dc.date.issued2015-02-01
dc.description.abstractObjective: Cardiovascular disease (CVD) is the leading cause of death in Europe. One of the candidate molecule affecting epigenetic mechanisms of CVD is the SIRT1, a subclass of sirtuins, is located on the long arm of chromosome 10 (10q21.3). Particularly, the relation between 2827 A>G polymorphism of the SIRT1 positioned on exon 2, leading to conversion of histidine to arginine, and the formation of CVD is not known yet. One of the activator of SIRT1, resveratrol, is also known as a cardioprotective molecule. On the other hand, the parameters including exercise, occupation and age affect CVD. The aim of the present study was to investigate the effect of the rs144124002 (2827 A>G) single nucleotide polymorphisms (SNP) of SIRT1 and exercise-occupation-age parameters on CVD. Methods: SNP of SIRT1 were analyzed using DNA isolation, the polymerase chain reaction (PCR) and restriction fragment length polymorphism. To do so, large cohorts of CVD patients (n=293) and healthy controls (n=117) who directed Cardiology Department of Bezmialem Vakıf University, Bezmialem Vakıf University Hospital were used. Results: In this study, when we assessed CVD and control groups about 2827 A>G polymorphism, all individuals were determined as homozygous genotype. We found a positive effect between the modifications of resveratrol, exercise, age and occupation and CVD (OR=0.17; CI 95%, 0.1-0.2; p≤0.001). Conclusion: This is the first study demonstrating the correlation between the SIRT1 rs144124002 polymorphism and CVD in Turkish population. (Anatolian J Cardiol 2015; 15: 103-6) Key words: SIRT1, resveratrol, epigenetic, polymorphism, cardiovascular diseaseen
dc.identifier10.1691/ph.2017.6786
dc.identifier.citationIZMIRLI M., GOKTEKIN O., Bacaksiz A., Uysal O., Kilic U., -The effect of the SIRT1 2827 A > G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease-, ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.15, ss.103-106, 2015
dc.identifier.doi10.5152/akd.2014.5214
dc.identifier.pubmed25252293
dc.identifier.scopus84979093789
dc.identifier.trdizinISSN: 2149-2263 / 2149-2271
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7277
dc.identifier.wosWOS:000351710500004
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleThe effect of the SIRT1 2827 A > G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease
dc.typeArticle
dspace.entity.typePublication
local.article.journalnamePharmazie
local.avesis.idb548c55f-4a6b-4797-838e-c003f536ad97
local.avesis.response7153
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublicationaf75b431-3b28-42b6-93a9-357a5d965904
relation.isAuthorOfPublication19df24c5-c3e8-4158-8eed-717f885c608d
relation.isAuthorOfPublication.latestForDiscovery19df24c5-c3e8-4158-8eed-717f885c608d
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
10-10.5152-akd.2014.5214.pdf
Size:
130.6 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Yayınlar - Eserler
Tıp Fakültesi
TR Dizin İndeksli Yayınlar Koleksiyonu