Publication: Electrodiagnostic methods to verify Guillain-Barré syndrome subtypes in Istanbul: A prospective multicenter study
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Date
2024-01-30
Authors
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TAŞDEMİR V.
Sirin N. G.
Cakar A.
Culha A.
Soysal A.
Elmali A. D.
GÜNDÜZ A.
Arslan B.
Yalcin D.
Atakli D.
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Abstract
Background and Aims: This study aimed to identify the clinical characteristics and electrodiagnostic subtypes of Guillain-Barre syndrome (GBS) in Istanbul. Methods: Patients with GBS were prospectively recruited between April 2019 and March 2022 and two electrodiagnostic examinations were performed on each patient. The criteria of Ho et al., Hadden et al., Rajabally et al., and Uncini et al. were compared for the differentiation of demyelinating and axonal subtypes, and their relations with anti-ganglioside antibodies were analyzed. Results: One hundred seventy-seven patients were included, 69 before the coronavirus disease 2019 pandemic (April 2019-February 2020) and 108 during the pandemic (March 2020-March 2022), without substantial changes in monthly frequencies. As compared with the criteria of Uncini et al., demyelinating GBS subtype diagnosis was more frequent according to the Ho et al. and Hadden et al. criteria (95/162, 58.6% vs. 110/174, 63.2% and 121/174, 69.5%, respectively), and less frequent according to Rajabally et al.\"s criteria (76/174, 43.7%). Fourteen patients\" diagnoses made using Rajabally et al.\"s criteria were shifted to the other subtype with the second electrodiagnostic examination. Of the 106 analyzed patients, 22 had immunoglobulin G anti-ganglioside antibodies (14 with the axonal subtype). They had less frequent sensory symptoms (54.5% vs. 83.1%, p = 0.009), a more frequent history of previous gastroenteritis (54.5% vs. 22.9%, p = 0.007), and a more severe disease as compared with those without antibodies. Interpretation: Serial electrodiagnostic examinations are more helpful for accurate subtype diagnosis of GBS because of the dynamic pathophysiology of the disease. We observed no significant increase in GBS frequency during the pandemic in this metropolis.
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Tıp, Dahili Tıp Bilimleri, Nöroloji, Yaşam Bilimleri, Sağlık Bilimleri, Temel Bilimler, Medicine, Internal Medicine Sciences, Neurology, Life Sciences, Health Sciences, Natural Sciences, KLİNİK NÖROLOJİ, Klinik Tıp, Klinik Tıp (MED), SİNİR BİLİMİ, Sinirbilim ve Davranış, Yaşam Bilimleri (LIFE), CLINICAL NEUROLOGY, CLINICAL MEDICINE, Clinical Medicine (MED), NEUROSCIENCES, NEUROSCIENCE & BEHAVIOR, Life Sciences (LIFE), Duyusal Sistemler, Gelişimsel Sinirbilim, Bilişsel Sinirbilim, Hücresel ve Moleküler Sinirbilim, Sinirbilim (çeşitli), Genel Sinirbilim, Nöroloji (klinik), İnsan Bilgisayar Etkileşimi, Fizik Bilimleri, Sensory Systems, Developmental Neuroscience, Cognitive Neuroscience, Cellular and Molecular Neuroscience, Neuroscience (miscellaneous), General Neuroscience, Neurology (clinical), Human-Computer Interaction, Physical Sciences
Citation
TAŞDEMİR V., Sirin N. G., Cakar A., Culha A., Soysal A., Elmali A. D., GÜNDÜZ A., Arslan B., Yalcin D., Atakli D., et al., "Electrodiagnostic methods to verify Guillain-Barré syndrome subtypes in Istanbul: A prospective multicenter study", JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2024