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Thyroid Hormone Levels in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease

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dc.contributor.authorTorun, EMEL
dc.contributor.authorOzgen, Ilker Tolga
dc.contributor.authorGokce, Selim
dc.contributor.authorAydin, SİNEM
dc.contributor.authorCesur, YAŞAR
dc.contributor.institutionauthorTORUN, EMEL
dc.contributor.institutionauthorÖZGEN, İLKER TOLGA
dc.contributor.institutionauthorVEHAPOĞLU TÜRKMEN, AYSEL
dc.contributor.institutionauthorAYDIN, SİNEM
dc.contributor.institutionauthorCESUR, YAŞAR
dc.date.accessioned2019-10-05T23:20:59Z
dc.date.available2019-10-05T23:20:59Z
dc.date.issued2014-01-01
dc.description.abstractObjective: We aimed to determine the association of thyroid functions with the components of metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) in pediatric obese patients. Methods: The study included 109 obese children (aged 9-15 years) and a control group of 44 healthy age and gender-matched children of normal weight. NAFLD was diagnosed by conventional ultrasound examination. We assessed the anthropometric data and serum biochemical parameters including lipid profile, alanine aminotransferase (ALT), fasting glucose and insulin levels and thyroid stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) levels. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as a measure of IR. Results: The mean age and gender distributions in the groups were similar (p=0.23). The mean body mass index (BMI) z-scores of obese children with grade 2-3 NAFLD were significantly higher than those of the obese children without hepatic steatosis (p<0.001). Mean ALT, triglyceride (TG) and LDL cholesterol increased and HDL-cholesterol significantly decreased as the hepatic steatosis increased (p<0.05). HOMA-IR levels in obese subjects with grade 2-3 NAFLD were significantly higher than those in both obese children without NAFLD and grade 1 NADFL (p=0.05 and 0.001, respectively). In the obese subjects, TSH levels were increased significantly as the degree of steatosis increased (p=0.04) but fT3 and fT4 levels were not different. In correlation analysis, TSH was significantly correlated with ALT, BMI SDS and the degree of steatosis. Conclusions: Obese children demonstrate an increase in TSH levels as the degree of steatosis increased.en
dc.identifier10.1111/j.1601-0825.2006.01297.x
dc.identifier.citationTorun E., Ozgen I. T. , Gokce S., Aydin S., Cesur Y., -Thyroid Hormone Levels in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease-, JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.6, ss.34-39, 2014
dc.identifier.doi10.4274/jcrpe.1155
dc.identifier.pubmed24637308
dc.identifier.scopus84895502500
dc.identifier.urihttps://hdl.handle.net/20.500.12645/10072
dc.identifier.wosWOS:000339650400006
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleThyroid Hormone Levels in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameORAL DISEASES
local.avesis.idfb4d4007-0529-43d1-9bb4-90a200266a20
local.avesis.response9946
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscoveryddd881a5-c7cb-41e5-b4e1-0693a98a0d29
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