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Inverted (hobnail) high-grade prostatic intraepithelial neoplasia and invasive inverted pattern

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dc.contributor.authorÖZNUR, MELTEM
dc.contributor.authorYILDIZ, PELİN
dc.contributor.authorBAHADIR, BURAK
dc.contributor.authorBEHZATOĞLU, KEMAL
dc.contributor.institutionauthorYILDIZ, PELİN
dc.date.accessioned2019-10-05T13:34:01Z
dc.date.available2019-10-05T13:34:01Z
dc.date.issued2015-10-01
dc.description.abstractHigh-grade prostatic intraepithelial neoplasia (HGPIN) is considered to be an important precursor for prostatic adenocarcinoma. The present study aimed to investigate the histological features of the uncommon inverted (hobnail) pattern of HGPIN in transrectal ultrasonographic (TRUS) prostatic needle biopsies from 13 cases. These 13 diagnosed cases of inverted HGPIN were identified out of a total of 2,034 TRUS biopsies (0.63%), obtained from patients suspected to have prostate cancer. The hobnail pattern is comprised of secretory cell nuclei, which are histologically localized at the luminal surface of the prostate gland, rather than the periphery, and exhibit reverse polarity. Histological examinations were performed and the results demonstrated that 5 of the 13 cases exhibited pure inverted histology, while HGPIN was observed to be histologically associated with other patterns in the remaining 8 patients. In addition, an association with adenocarcinoma was identified in 7 of the 13 cases. All 7 carcinomas accompanied by inverted HGPIN were conventional acinar adenocarcinoma cases; of note, for these 7 cases, the Gleason score was 7 for each. One acinar adenocarcinoma case accompanying inverted HGPIN demonstrated hobnail characteristics in large areas of the invasive component. It was observed that nuclei were proliferated in the invasive cribriform glands, which was comparable to that of inverted HGPIN, and were located on the cytoplasmic luminal surface; a similar morphology was also observed in individual glands. In conclusion, the results of the present study suggested that the hobnail HGPIN pattern may be of diagnostic importance due to its high association with adenocarcinoma and the high Gleason scores in the accompanying carcinomas.en
dc.identifier
dc.identifier.citationÖZNUR M., BAYKAL KOCA S., YILDIZ P., BAHADIR B., BEHZATOĞLU K., -Inverted (hobnail) high-grade prostatic intraepithelial neoplasia and invasive inverted pattern-, ONCOLOGY LETTERS, ss.2395-2399, 2015
dc.identifier.doi10.3892/ol.2015.3584
dc.identifier.pubmed26622858
dc.identifier.scopus84940061812
dc.identifier.urihttps://hdl.handle.net/20.500.12645/2399
dc.identifier.wosWOS:000362999500080
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleInverted (hobnail) high-grade prostatic intraepithelial neoplasia and invasive inverted pattern
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameKARTAL EĞİTİM VE ARAŞTIRMA HASTANESİ TIP DERGİSİ
local.avesis.id3a6e6fb4-84d0-4594-9cd8-e723258aac20
local.avesis.response2269
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication4c9a734d-36ee-4704-9e15-7012fd2ca3fb
relation.isAuthorOfPublication.latestForDiscovery4c9a734d-36ee-4704-9e15-7012fd2ca3fb
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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