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Antigenotoxic and antioxidant potentials of newly derivatized compound naringenin-oxime relative to naringenin on human mononuclear cells

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dc.contributor.authorKocyigit, ABDÜRRAHİM
dc.contributor.authorKoyuncu, Ismail
dc.contributor.authorTaskin, Abdullah
dc.contributor.authorDikilitas, Murat
dc.contributor.authorBahadori, FATEMEH
dc.contributor.authorTurkkan, Baki
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorBAHADORİ, FATEMEH
dc.date.accessioned2019-10-05T23:21:59Z
dc.date.available2019-10-05T23:21:59Z
dc.date.issued2016-01-02
dc.description.abstractWe investigated antigenotoxic and antioxidative effects of newly derivatized compound naringenin-oxime (NG-Ox) compared to its mother compound naringenin (NG) against oxidative damage induced by hydrogen peroxide (HP) in human peripheral blood mononuclear cells (PBMC). Antigenotoxic activity was assessed using alkaline single cell gel electrophoresis assay (comet assay). Oxidative status was evaluated by measurement of total antioxidant status, total oxidant status and lipid hydroperoxide levels in the cells. Oxidative stress index was also calculated. Both NG and NG-Ox show a protective effect against HP-induced oxidative damage on PBMC and are able to reduce oxidative stress. The percentage of antigenotoxic and antioxidant potential progressively increased in a dose-dependent manner. However, these activities were found to be more significant in NG-Ox-treated cells than in NG-treated cells. Taken together, these observations provide evidences indicating that both NG and NG-Ox are able to protect cells against oxidative damage and apparently NG-Ox is more effective than NG.
dc.identifier
dc.identifier.citationKocyigit A., Koyuncu I., Taskin A., Dikilitas M., Bahadori F., Turkkan B., -Antigenotoxic and antioxidant potentials of newly derivatized compound naringenin-oxime relative to naringenin on human mononuclear cells-, DRUG AND CHEMICAL TOXICOLOGY, cilt.39, ss.66-73, 2016
dc.identifier.pubmed25826180
dc.identifier.urihttps://hdl.handle.net/20.500.12645/10119
dc.language.isoen
dc.titleAntigenotoxic and antioxidant potentials of newly derivatized compound naringenin-oxime relative to naringenin on human mononuclear cells
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameINTERNATIONAL JOURNAL OF CLINICAL PHARMACY
local.avesis.idfc9b38ec-8164-44af-b75f-ed1ac1bf21ad
relation.isAuthorOfPublication75babbd2-f46b-4121-aa00-54d883a6f907
relation.isAuthorOfPublication14c64c63-5d3c-42d0-9f93-cf4b7af6da81
relation.isAuthorOfPublication.latestForDiscovery14c64c63-5d3c-42d0-9f93-cf4b7af6da81
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