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Neopterin and Soluble CD14 Levels as Indicators of Immune Activation in Cases with Indeterminate Pattern and True Positive HIV-1 Infection.

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dc.contributor.authorUYSAL, HARUN
dc.contributor.authorSOHRABI, P
dc.contributor.authorHABIP, Z
dc.contributor.authorSARIBAS, S
dc.contributor.authorKOCAZEYBEK, E
dc.contributor.authorSEYHAN, F
dc.contributor.authorCALıŞKAN, R
dc.contributor.authorBONABI, E
dc.contributor.authorYUKSEL, PELİN
dc.contributor.authorBIRINCI, I
dc.contributor.authorUysal, O
dc.contributor.authorKOCAZEYBEK, B
dc.contributor.institutionauthorYÜKSEL MAYDA, PELİN
dc.contributor.institutionauthorUYSAL, ÖMER
dc.date.accessioned2019-10-05T12:45:27Z
dc.date.available2019-10-05T12:45:27Z
dc.date.issued2016-03-31
dc.description.abstractBackground: We aimed to evaluate the roles of the plasma immune activation biomarkers neopterin and soluble CD14 (sCD14) in the indirect assessment of the immune activation status of patients with the indeterminate HIV-1 (IHIV-1) pattern and a true HIV-1-positive infection (PCG). Methods: This cross-sectional and descriptive study included eighty-eight patients with the IHIV-1 pattern, 100 patients in the PCG, and 100 people in a healthy control group (HCG). Neopterin and sCD14 levels were determined by competitive and sandwich ELISA methods, respectively. Results: Mean neopterin and sCD14 levels among those with the IHIV-1 pattern were significantly lower than among the PCG (p < 0.001 and p = 0.001, respectively), but they were similiar to those in the HCG (p = 0.57 and p = 0.66, respectively. Mean neopterin and sCD14 levels among the PCG were found to be significantly higher than among those with the IHIV-1 pattern (p < 0.001 and p = 0.001, respectively) and among those in the HCG (p = 0.001, p < 0.001, respectively). Neopterin did not have adequate predictive value for identifying those in the PCG (area under the curve [AUC] = 0.534; 95% CI, 0.463-0.605; p = 0.4256); sCD14 also had poor predictive value but high specificity (100%) for identifying those in the PCG (AUC = 0.627; 95% CI, 0.556-0.694; p = 0.0036). Conclusions: While low levels of these two biomarkers were detected among those with the IHIV-1 pattern, they were found in high levels among those in the PCG. These two markers obviously cannot be used as a sceening test because they have low sensitivies. Taken together, we suggest that neopterin and sCD14 may be helpful because they both have high specificity (92%-100%) as indirect non-specific markers for predicting the immune activation status of individuals, whether or not they have true positive HIV-1.en
dc.description.sponsorshipİstanbul Üniversitesi
dc.identifier
dc.identifier.citationUYSAL H., SOHRABI P., HABIP Z., SARIBAS S., KOCAZEYBEK E., SEYHAN F., CALıŞKAN R., BONABI E., YUKSEL P., BIRINCI I., et al., -Neopterin and Soluble CD14 Levels as Indicators of Immune Activation in Cases with Indeterminate Pattern and True Positive HIV-1 Infection.-, PloS one, cilt.11, 2016
dc.identifier.doi10.1371/journal.pone.0152258
dc.identifier.pubmed27031691
dc.identifier.scopus84977671601
dc.identifier.urihttps://hdl.handle.net/20.500.12645/496
dc.identifier.wosWOS:000373121800047
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleNeopterin and Soluble CD14 Levels as Indicators of Immune Activation in Cases with Indeterminate Pattern and True Positive HIV-1 Infection.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTarih ve Toplum
local.avesis.id09486874-4fcd-4135-9aea-64c43e471c5d
local.avesis.response366
local.org.facultyTıp Fakültesi
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublicationa7da1ef6-442b-46fc-8c6c-601442ec1778
relation.isAuthorOfPublication19df24c5-c3e8-4158-8eed-717f885c608d
relation.isAuthorOfPublication.latestForDiscovery19df24c5-c3e8-4158-8eed-717f885c608d
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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