Person: HACIOSMANOĞLU, EBRU
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Publication Metadata only Impact of N‑Acetylcysteine and Antibiotics Against Single and Dual Species Bioflms of Pseudomonas aeruginosa and Achromobacter xylosoxidans(2022-11-01) Yılmaz F. N.; Hacıoğlu M.; Hacıosmanoğlu E.; HACIOSMANOĞLU, EBRUPublication Metadata only CUSCUTA CAMPESTRİS TEDAVİSİ İLE MİDE KANSERİ HÜCRELERİNDE APOPTOZUN İNDÜKLENMESİ VE REAKTİF OKSİJEN TÜRLERİNİN OLUŞUMU YOLUYLA PROLİFERASYONUN ENGELLENMESİ(2021-08-01T00:00:00Z) Koçyiğit, Abdürrahim; KOÇYİĞİT, ABDÜRRAHİM; HACIOSMANOĞLU, EBRUPublication Open Access Synthesis of oleanolic acid hydrazide-hydrazone hybrid derivatives and investigation of their cytotoxic effects on A549 human lung cancer cells(2022-01-01T00:00:00Z) Şenol, Halil; Mercümek, Berre; Şahin, Rabia Büşra; Kapucu, Halil Burak; Hacıosmanoğlu, Ebru; ŞENOL, HALIL; MERCÜMEK, BERRE; HACIOSMANOĞLU, EBRUPublication Metadata only Anti-microbial, anti-oxidant and wound healing capabilities of Aloe vera-incorporated hybrid nanoflowers(2023-01-01) Altinkaynak C.; HACIOSMANOĞLU E.; Ekremoglu M.; HACIOĞLU M.; ÖZDEMİR N.; HACIOSMANOĞLU, EBRU© 2023 The Society for Biotechnology, JapanThe active ingredients of Aloe vera have attracted attention for their potential use in nanotechnology-based medical applications and biomaterial production. It has many therapeutic applications in modern world. This study used Aloe vera extract in different concentrations to synthesize Aloe vera-incorporated hybrid nanoflowers (AV-Nfs). The most uniform morphology in the nanoflowers obtained was at a concentration of 2 mL. The AV-Nfs were well characterized by scanning electron microscopy, X-ray spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction (XRD). The highest peroxidase-mimicking activity of the components was 1.488 EU/mg at 60°C and pH 6. The DPPH assay determined the antioxidant activity of the components and the MTT assay tested on CCD-1072Sk fibroblast cell line determined the effect of AV-Nfs on cell proliferation. Separate treatment of AV-Nfs with Cu3(PO4)2·3H2O significantly increased cell proliferation according to free Aloe vera and CuSO4. In vitro wound healing results showed that AV-Nfs could significantly close wounds compared to free Aloe vera. In this study, AV-Nfs showed antimicrobial activity against Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli and Klebsiella pneumoniae at minimum inhibitory concentration of 625 μg/mL, suggesting that AV-Nfs may be used in wound healing applications with enhanced biological properties. AV-Nfs showed no activity against the yeast Candida albicans.Publication Open Access Anti-Inflammatory Effects of Melatonin in Rats with Induced Type 2 Diabetes Mellitus(2022-04-01T00:00:00Z) YAPIŞLAR, Hande; HACIOSMANOĞLU, Ebru; Sarioglu, Turkan; Degirmencioglu, Sevgin; Sogut, Ibrahim; Poteser, Michael; Ekmekcioglu, Cem; HACIOSMANOĞLU, EBRUIntroduction: Insulin resistance is associated with a pro-inflammatory state increasing the risk for complications in patients with type 2 diabetes mellitus (T2DM). In addition to its chronobiotic effects, the pineal hormone melatonin is known to exert anti-inflammatory and antioxidant effects. Melatonin was also suggested to affect insulin secretion. The aim of this study was therefore to investigate the effect of melatonin on inflammation in diabetic rats and to study the possible involvement of the melatonin receptor, MT2. Materials and Methods: Male Sprague Dawley rats were randomly divided into four experimental groups (n = 10 per group): (1) control, (2) streptozotocin/nicotinamide induced diabetes type 2 (T2DM), (3) T2DM treated with melatonin (500 mu g/kg/day), and (4) T2DM treated with melatonin (500 mu g/kg/day for 6 weeks) and the selective MT2 receptor antagonist luzindole (0.25 g/kg/day for 6 weeks). Blood samples were taken for biochemical parameters and various tissue samples (liver, adipose tissue, brain) were removed for immunohistochemistry (IHC), Western blot (WB), and Q-PCR analyses, respectively. Results: Melatonin significantly reduced increased blood levels of liver transaminases (AST, ALT), blood urea nitrogen (BUN), triglyceride, very low-density lipoprotein (VLDL), and cholesterol in diabetic rats with luzindole treatment partly reversing this effect regarding the lipids. Furthermore, the liver and adipose tissues of T2DM rats treated with melatonin showed lower expression of the inflammatory markers IL-1 beta, IL-6, TNF-alpha, and NF-kappa B as compared to the T2DM group without melatonin. The results also showed that the MT2 receptor is at least partly involved in the protective effects of melatonin. Conclusions: Our results suggest that melatonin exerts relevant anti-inflammatory effects on various tissues in type 2 diabetic rats.Publication Metadata only Vanilin/PEI Esaslı Hidrojellerin Kendi Kendini Onarma ve Hücre Canlılığı Özelliklerinin İncelenmesi(2022-09-04) Yaşar M.; Oktay B.; Dal Yöntem F.; Hacıosmanoğlu E.; Kayaman Apohan N.; HACIOSMANOĞLU, EBRUPublication Metadata only The Role of Some Selenoproteins in the Etiopathogenesis of Breast Cancer(2022-08-01) Öğüt S.; Hacıosmanoğlu E.; Değirmencioğlu S.; Bahtiyar N.; Cinemre F. B.; Aydemir B.; Karaçetin D.; Kural A.; Güneş M. E.; Bektaş M.; HACIOSMANOĞLU, EBRUPublication Metadata only Development of Novel Mitochondrial Fission Inhibitors Targeting Drp1-GTPase Interaction(2022-09-01) Dal Yöntem F.; Baday S.; Bulut Ş.; Ghaderkalankesh B.; Hacıosmanoğlu E.; Bektaş M.; Akçakaya H.; HACIOSMANOĞLU, EBRUPublication Metadata only Comparing the Neuroprotective Effects of Telmisartan, Perindopril, and Nebivolol Against Lipopolysaccharide-Induced Injury in Neuron-Like Cells.(2022-07-29) Şen S.; Hacıosmanoğlu E.; HACIOSMANOĞLU, EBRUPublication Metadata only Comparing The Effects Of Telmisartan, Perindopril, And Nebivolol On Neuroprotection In LPS-Induced Neuron Like Cells(2022-09-02) Hacıosmanoğlu E.; Şen S.; HACIOSMANOĞLU, EBRU