Person: ÖZER, ÖMER FARUK
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Publication Open Access Assessment of serum endocan levels in patients with beta-thalassemia minor(2022-02-01T00:00:00Z) Zorlu, Mehmet; Ozer, Ömer Faruk; Karatoprak, Cumali; Kıskaç, Muharrem; Çakırca, Mustafa; ZORLU, MEHMET; ÖZER, ÖMER FARUK; KARATOPRAK, CUMALİObjective: Beta-thalassemia minor is a blood disease caused by a hereditary decrease in beta-globin synthesis, frequently leading to hypochromic microcytic anemia. Formerly called endothelial cell-specific molecule 1, endocan is a proteoglycan released by vascular endothelial cells in many organs. Our aim was to investigate the relationship between the beta-thalassemia minor patients and the healthy control group in terms of serum endocan level. Methods: The study was performed in a total of 80 subjects. They were divided into two groups, the beta-thalassemia minor group (n=40) and the healthy control group (n=40). Serum endocan levels, age, sex, body mass index value, and tobacco use data of these groups were compared. Results: No statistically significant difference was detected between the two groups in terms of age, sex, and body mass index values (p>0.05). Endocan levels were measured to be 206.85±88.1 pg/mL in the beta-thalassemia minor group and 236.1±162.8 pg/mL in the control group with no significant difference between the groups in terms of serum endocan levels (p>0.05). Conclusions: In our study, there was no change in endocan level in beta-thalassemia minor. This might be because serum endocan levels are affected by multi-factorial reasons. Serum endocan levels may be altered secondarily to decreased beta-globin chain, increased sympathetic activity due to anemia, or platelet dysfunction induced by oxidative stress in beta-thalassemia minor. Further multicenter studies involving more patients are necessary to demonstrate this.Publication Open Access Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide.(2020-11-01T00:00:00Z) Doğan, R; Hafız, AM; Gucin, Z; Ozer, OF; Ozturan, O; Yenigun, Alper; DOĞAN, REMZI; GÜCİN, ZÜHAL; ÖZER, ÖMER FARUK; YENİGÜN, ALPER; ÖZTURAN, ORHANPublication Metadata only Protective effect of dexpanthenol against nephrotoxic effect of amikacin: An experimental study(2017-05-01) Dogan, ELİF ECE; ERKOC, Reha; EKINCI, Iskender; HAMDARD, Jamshid; DONER, Baris; KARATOPRAK, CUMALİ; Coban, GANİME; Ozer, Omer Faruk; Kazancioglu, RÜMEYZA; DOĞAN, ELİF ECE; KARATOPRAK, CUMALİ; ÇOBAN, GANİME; ÖZER, ÖMER FARUK; KAZANCIOĞLU, RÜMEYZABackground: Amikacin has the largest spectrum among aminoglycosides, its nephrotoxic effect limits its utilization. Our purpose in this study is to review the protective effect of dexpanthenol against the nephrotoxic effect of amikacin, accompanied with histopathological and biochemical parameters.Publication Open Access Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study.(2022-05-01T00:00:00Z) Erdoğan, Fırat; Şenkal, Evrim; Özer, Ömer Faruk; İpek, İlke Özahi; Altuntaş, Şükriye Leyla; Özde, Şükriye; ÖZER, ÖMER FARUKBackground: Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction. Objective: Our aim in this study was to investigate the association between GDM and oxidative stress markers measured in plasma, with regard to revealing changes to total antioxidant capacity (TAC) and total oxidant status (TOS) among mothers showing impairments in oral glucose tolerance tests (OGTTs). Design and setting: Prospective study at a university hospital in Turkey. Methods: The study group consisted of 50 mothers with GDM, and 59 healthy mothers served as controls. Umbilical cord blood samples were taken from all mothers during delivery and breast milk samples on the fifth day after delivery. TAC, TOS, thiol and disulfide levels were measured. Results: No statistically significant relationship between the blood and milk samples could be found. An analysis on correlations between TAC, TOS and certain parameters revealed that there were negative correlations between TOS and total thiol (r = -0.386; P < 0.001) and between TOS and disulfide (r = -0.388; P < 0.001) in milk in the control group. However, these findings were not observed in the study group. Conclusion: Our findings suggested that a compensatory mechanism of oxidative stress was expected to be present in gestational diabetes mellitus and that this might be ameliorated through good glycemic regulation and antioxidant supplementation.Publication Open Access Could Vitamin K1 Deficiency be the Problem in Iron Deficiency and/or Anemia in Premenopausal Women?(2022-04-01T00:00:00Z) Karatoprak, Cumali; Şekerci, Abdusselam; Karaaslan, Tahsin; Olgaç, Atilla; Özer, Ömer Faruk; Selek, Şahabettin; Köktaşoğlu, Fatmanur; Ekinci, İskender; KARATOPRAK, CUMALİ; ŞEKERCİ, ABDÜSSELAM; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİNObjective: The etiology of iron deficiency anemia, which develops as a result of menstrual bleeding in the premenopausal period, is unknown. Vitamin K1 has an important role in the coagulation cascade and is not a well known vitamin. The aim of this study was to investigate whether or not Vitamin K1 had a role in anemia developing in the premenopausal period, for which no additional reason could be found. Methods: This study included a patient group of women aged 18-50 years, who had a regular menstrual cycle. Patients who were found to have iron deficiency, who were evaluated hematologically, gastrointestinally and gynecologically, and who did not have a pathology that would lead to iron deficiency were included in the study group.The control group comprised volunteers with regular menstrual cycles who had not been previously determined with iron deficiency. In the study, Vitamin K1, Hemogram, ferritin, iron, total iron binding capacity were examined. The Vitamin K1 level was measured by two different methods both using ELISA and liquid chromatography-mass spectrometry (LC-MS/MS) methods. In addition, a record was made for all participants including demographic characteristics, lifestyle habits, and number of menstruating days. The obtained data were then compared between the groups. Results: A total of 88 voluntary participants were included in the study as 45 patients with iron deficiency anemia (IDA) and a control group of 43 subjects. The age, body mass index, partial thromboplastin, International normalized ratio, active partial thromboplastin time, folic acid, and Vitamin B12 values were similar in both groups. In both methods, no significant difference was determined between the groups in respect of the Vitamin K1 level (p=0.9 in ELISA method and p=0.3 in LC-MS/MS method). The number of menstruation days was determined to be significantly higher in the anemic group than in the control group (p=0.002). Conclusion: From the results of this study, it was considered that IDA developed in premenopausal women with a longer period of menstrual bleeding. However, Vitamin K1 deficiency was not considered to be one of the underlying reasons for longer menstrual bleeding.Publication Metadata only Total antioxidant status and oxidative stress in recurrent aphthous stomatitis(2016-03-01) TUGRUL, Selahattin; Kocyigit, ABDÜRRAHİM; Dogan, REMZİ; Eren, SABRİ BAKİ; SENTURK, EROL; Ozturan, ORHAN; OZAR, Omer Faruk; KOÇYİĞİT, ABDÜRRAHİM; DOĞAN, REMZI; EREN, SABRİ BAKİ; ŞENTÜRK, EROL; ÖZTURAN, ORHAN; ÖZER, ÖMER FARUKBackgroundRecurrent aphthous stomatitis is an idiopathic, chronic, recurrent inflammatory disease of the oral mucosa. It is thought that oxidative stress caused by systemic inflammation plays a basic role in the etiopathogenesis of recurrent aphthous stomatitis. The aim of this study is to review oxidative status and DNA damage in recurrent aphthous stomatitis.Publication Open Access The Effect of Serum Bone Sialoprotein Levels on Tympanosclerosis(2020-07-01T00:00:00Z) Baki, Ahmet; Yildiz, Muhammet; ÖZER, Ömer Faruk; ÇAĞLAR, Hifa Gülru; ÖZER, ÖMER FARUK; ÇAĞLAR, HİFA GÜLRUObjective: This study aimed to investigate serum bone sialoprotein (BSP) levels in patients with tympanosclerosis (TS). Methods: We included into this study 24 patients with TS and 24 asymptomatic healthy volunteers. Our study consisted of two groups: TS group (n=24), comprising of patients who underwent surgery for chronic otitis media and had tympanosclerotic plaques; and a control group (n=24), comprising of healthy individuals without ear problems. The serum BSP levels were measured and the results were compared between the two groups. Results: In the TS group, there were 15 female and nine male patients. The ages of the females ranged from 24 to 54 years, while those of the males ranged from 34 to 55 years; the average age was 40.46 +/- 9.75 and 43.11 +/- 6.77, respectively. In the control group, there were 14 females and ten males. The ages of the females ranged from 30 to 48 years, while those of the males ranged from 27 to 47 years; the average age was 40.25 +/- 5.28 and 38.4 +/- 27.08, respectively. There was a statistically significant difference in BSP levels between the two groups (p=0.001). In addition, there was a moderate positive correlation between BSP and hearing levels. Conclusion: The serum BSP levels were higher in the TS group than in the control group and might have some effect on TS. Further studies on a large number of subjects using serum and tissue BSP levels should be designed to affirm the effects of BSP on TS.Publication Metadata only Upper reference limits for serum thyroid stimulating hormone levels in Turkish children(2014-06-01) ARAL, H.; Ozer, O. F.; ONUR, H.; ÇİLİNGİRTÜRK, AHMET METE; AKYILDIZ, M.; Ozgen, I. T.; GUVENEN, GÜVENÇ; KACAN, P. A.; COMERT, S.; SERIN, E.; ÖZER, ÖMER FARUK; ÖZGEN, İLKER TOLGA; GÜVENEN, GÜVENÇPublication Metadata only Decreased Levels of Fasting Serum Leptin in Patients With Schizophrenia: A Case-Control Study(2020-01-01T00:00:00Z) Şahbaz, Çiğdem; Kurtulmuş, Ayşe; Kırkpınar, İsmet; Gülöksüz, Sinan; ÖZER, ÖMER FARUKPublication Open Access Paraoxonase-1 Phenotype and Its Relationship with Mean Platelet Volume and Oxidative Stress in Coronary Artery Disease(2015-09-01) SELEK, ŞAHBETTİN ; ÖZER, ÖMER FARUK ; GOKTEKİN, Omer ; KOÇYİĞİT, ABDÜRRAHİM; KALINBACOGLU, Ceren; ISLEK, Irem ; ISLEK, Tuğba; ARPACI, Beyza; Erol, Neval; MEYDAN, Sedat; GÜLER, ERAY METİN; SELEK, ŞAHABETTİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİM; MEYDAN, SEDAT; GÜLER, ERAY METİNObjective: Paraoxonase-1 (PON1) 192 QR polymorphism is believed to be an important protective factor for coronary artery disease (CAD); oxidative stress plays a key role in the development of atherosclerotic CAD. Mean platelet volume (MPV) is also central to the processes, including pathophysiology of CAD and endothelial dysfunction. Thus, we aimed to determine the PON1 phenotype, MPV, and oxidative stress parameters in patients with angiographically proven CAD and to compare them with those in healthy subjects. Methods: Fifty-five CAD patients were diagnosed according to the angiography results, and 37 healthy subjects were present in this study. Serum paraoxonase and arylesterase activities were spectrophotometrically measured. Phenotype distribution was evaluated by the salt-stimulated paraoxonase activity according to arylesterase activity. Oxidative stress markers were evaluated by measuring serum total oxidant status (TOS) and total antioxidant status (TAS) as well as oxidative stress index. Results: In this study, the ratio of salt-stimulated paraoxonase/ OSI levels (S-PON1/OSI) were lower in the CAD patients and the differences were statistically significant (p<0.05). Therefore, the ratio of salt-stimulated paraoxonase/MPV (S -PON1/MPV) and S- PON1/OSI level were significantly different in the CAD patients as compared with controls group (p<0.01). Conclusion: Our study has suggested that S-PON1/OSI and SPON1/ MPV may play a significant role in CAD. To the best of our knowledge, the present study is the first to study the relationship among PON1 phenotype, MPV, and OSI in CAD patients. Thus, lowering of the oxidative stress and the regulation of MPV strategies may be a promising approach for the treatment of CAD.