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KAZANCIOĞLU, RÜMEYZA

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RÜMEYZA
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    PublicationOpen Access
    International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Eastern and Central Europe
    (2021-05-01T00:00:00Z) Dębska-Ślizień, Alicja; Bello, Aminu K.; Johnson, David W.; Jha, Vivekanand; Harris, David C.H.; Levin, Adeera; Tonelli, Marcello; Saad, Syed; Zaidi, Deenaz; Osman, Mohamed A.; Ye, Feng; Khan, Maryam; Lunney, Meaghan; Okpechi, Ikechi G.; Turan Kazancioglu, Rümeyza; KAZANCIOĞLU, RÜMEYZA
    Provision of adequate kidney care for patients with chronic kidney disease or kidney failure (KF) is costly and requires extensive resources. There is an inequality in the global distribution of wealth and resources needed to provide this care. In this second iteration of the International Society of Nephrology Global Kidney Health Atlas, we present data for countries in Eastern and Central Europe. In the region, the median prevalence of chronic kidney disease was 13.15% and treated KF was 764 per million population, respectively, slightly higher than the global median of 759 per million population. In most countries in the region, over 90% of dialysis patients were on hemodialysis and patients with a functioning graft represented less than one-third of total patients with treated KF. The median annual costs for maintenance hemodialysis were close to the global median, and public funding provided nearly universal coverage of the costs of kidney replacement therapy. Nephrologists were primarily responsible for KF care. All countries had the capacity to provide long-term hemodialysis, and 95% had the capacity to provide peritoneal dialysis. Home hemodialysis was generally not available. Kidney transplantation and conservative care were available across most of the region. Almost all countries had official dialysis and transplantation registries. Eastern and Central Europe is a region with a high burden of chronic kidney disease and variable capacity to deal with it. Insufficient funding and workforce shortages coupled with increasing comorbidities among aging patients and underutilization of cost-effective dialysis therapies such as peritoneal dialysis and kidney transplantation may compromise the quality of care for patients with KF. Some workforce shortages could be addressed by improving the organization of nephrological care in some countries of the region.
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    PublicationOpen Access
    Comparative Evaluation of Orthostatic Hypotension in Patients with Diabetic Nephropathy.
    (2021-07-20T00:00:00Z) Aytaş, Gamze; Elçioğlu, Ömer C; Kazancıoğlu, Rümeyza; Gürsu, Meltem; Artan, A Serra; Yabacı, Ayşegül; Soysal, PINAR; Bilgi, Kadir; Özçelik, Semra; KAZANCIOĞLU, RÜMEYZA; ELÇİOĞLU, ÖMER CELAL; GÜRSU, MELTEM; YABACI TAK, AYŞEGÜL; SOYSAL, PINAR; ÖZÇELİK, SEMRA
    Introduction: Orthostatic hypotension (OH) affects 5-20% of the population. Our study investigates the presence of OH in diabetic nephropathy (DNP) patients and the factors affecting OH in comparison with nondiabetic chronic kidney disease (NDCKD) patients. Method: Patients presented to the nephrology clinic, and those who consented were included in the study. DNP was defined by kidney biopsy and/or clinical criteria. NDCKD patients of the same sex, age, and eGFR were matched to DNP patients. Demographic parameters and medications were obtained from the records. OH was determined by Mayo clinic criteria. The same researcher used an electronic device to measure blood pressure (BP). All samples were taken and analyzed the same day for biochemical and hematologic parameters and albuminuria. Results: 112 (51 F, 61 M, mean age: 62.56 ± 9.35 years) DNP and 94 (40 F, 54 M, mean age: 62.23 ± 10.08 years) NDCKD patients were included. There was no significant difference between DNP and NDCKD groups in terms of OH prevalence (70.5 vs. 61.7%, p = 0.181). Male patients had significantly higher OH prevalence than female patients (74.7 vs. 60.0%, p = 0.026). There was no significant difference in change in systolic BP between the groups (24.00 [10.00-32.00] mm Hg vs. 24.00 [13.75-30.25] mm Hg, p = 0.797), but the change in diastolic BP was significantly higher in the DNP group (8.00 [2.00-13.00] mm Hg vs. 6.00 [2.00-9.00] mm Hg, p = 0.025). In the DNP group, patients with OH had significantly higher uric acid levels than those without OH (7.18 ± 1.55 vs. 6.36 ± 1.65 mg/dL, p = 0.017). And, 73.7% of patients on calcium channel blockers developed OH (p = 0.015), and OH developed in 80.6% of 36 patients on alpha-blockers (p = 0.049). Conclusion: OH prevalence is very high in CKD, and etiology of CKD does not have a statistically significant effect on the frequency of OH, despite a difference that could be meaningful clinically. Therefore, patients with CKD are checked for OH, with or without concurrent diabetes mellitus. Evaluation of postural BP changes should be a part of nephrology practice.
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    Otozomal Dominant Polikistik Böbrek Hastalığında Total Oksidan/Antioksidan Seviyelerin Böbrek Fonksiyonlarıyla İlişkisi
    (2021-10-13T00:00:00Z) Aris, Özlem; Büyükaydın, Banu; Artan, Ayşe Serra; Mirioğlu, Şafak; Gürsu, Meltem; Kazancıoğlu, Rümeyza; Elçioğlu, Ömer Celal; MİRİOĞLU, ŞAFAK; GÜRSU, MELTEM; KAZANCIOĞLU, RÜMEYZA; ELÇİOĞLU, ÖMER CELAL
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    Investigation of optimum hemoglobin levels in older patients with chronic kidney disease.
    (2022-09-22T00:00:00Z) Kara, O; Soysal, P; Kiskac, M; Smith, L; Karışmaz, A; Kazancioglu, Rümeyza; SOYSAL, PINAR; KAZANCIOĞLU, RÜMEYZA
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    PublicationOpen Access
    Determinants of mortality in a large group of hemodialysis patients hospitalized for COVID-19
    (2021-01-14T00:00:00Z) Turgutalp, Kenan; Ozturk, Savas; Arici, Mustafa; Eren, Necmi; Gorgulu, Numan; Islam, Mahmut; Uzun, Sami; Sakaci, Tamer; Aydin, Zeki; Sengul, Erkan; Demirelli, Bulent; Ayar, Yavuz; Altiparmak, Mehmet Riza; Sipahi, Savas; Mentes, Ilay Berke; Ozler, Tuba Elif; Oguz, Ebru Gok; Huddam, Bulent; Hur, Ender; Kazancioglu, Rümeyza; Gungor, Ozkan; Tokgoz, Bulent; Tonbul, Halil Zeki; Yildiz, Alaattin; Sezer, Siren; Odabas, Ali Riza; Ates, Kenan; KAZANCIOĞLU, RÜMEYZA
    Background Maintenance hemodialysis (MHD) patients are at increased risk for coronavirus disease 2019 (COVID-19). The aim of this study was to describe clinical, laboratory, and radiologic characteristics and determinants of mortality in a large group of MHD patients hospitalized for COVID-19. Methods This multicenter, retrospective, observational study collected data from 47 nephrology clinics in Turkey. Baseline clinical, laboratory and radiological characteristics, and COVID-19 treatments during hospitalization, need for intensive care and mechanical ventilation were recorded. The main study outcome was in-hospital mortality and the determinants were analyzed by Cox regression survival analysis. Results Of 567 MHD patients, 93 (16.3%) patients died, 134 (23.6%) patients admitted to intensive care unit (ICU) and 91 of the ones in ICU (67.9%) needed mechanical ventilation. Patients who died were older (median age, 66 [57–74] vs. 63 [52–71] years, p = 0.019), had more congestive heart failure (34.9% versus 20.7%, p = 0.004) and chronic obstructive pulmonary disease (23.6% versus 12.7%, p = 0.008) compared to the discharged patients. Most patients (89.6%) had radiological manifestations compatible with COVID-19 pulmonary involvement. Median platelet (166 × 103 per mm3 versus 192 × 103 per mm3, p = 0.011) and lymphocyte (800 per mm3 versus 1000 per mm3, p < 0.001) counts and albumin levels (median, 3.2 g/dl versus 3.5 g/dl, p = 0.001) on admission were lower in patients who died. Age (HR: 1.022 [95% CI, 1.003–1.041], p = 0.025), severe-critical disease clinical presentation at the time of diagnosis (HR: 6.223 [95% CI, 2.168–17.863], p < 0.001), presence of congestive heart failure (HR: 2.247 [95% CI, 1.228–4.111], p = 0.009), ferritin levels on admission (HR; 1.057 [95% CI, 1.006–1.111], p = 0.028), elevation of aspartate aminotransferase (AST) (HR; 3.909 [95% CI, 2.143–7.132], p < 0.001) and low platelet count (< 150 × 103 per mm3) during hospitalization (HR; 1.864 [95% CI, 1.025–3.390], p = 0.041) were risk factors for mortality. Conclusion Hospitalized MHD patients with COVID-19 had a high mortality rate. Older age, presence of heart failure, clinical severity of the disease at presentation, ferritin level on admission, decrease in platelet count and increase in AST level during hospitalization may be used to predict the mortality risk of these patients.
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    PublicationOpen Access
    Availability, coverage, and scope of health information systems for kidney care across world countries and regions.
    (2020-12-22T00:00:00Z) See, Emily J; Bello, Aminu K; Levin, Adeera; Lunney, Meaghan; Osman, Mohamed A; Ye, Feng; Ashuntantang, Gloria E; Bellorin-Font, Ezequiel; Benghanem Gharbi, Mohammed; Davison, Sara; Ghnaimat, Mohammad; Harden, Paul; Htay, Htay; Jha, Vivekanand; Kalantar-Zadeh, Kamyar; Kerr, Peter G; Klarenbach, Scott; Kovesdy, Csaba P; Luyckx, Valerie; Neuen, Brendon; O'Donoghue, Donal; Ossareh, Shahrzad; Perl, Jeffrey; Rashid, Harun Ur; Rondeau, Eric; Syed, Saad; Sola, Laura; Tchokhonelidze, Irma; Tesar, Vladimir; Tungsanga, Kriang; Kazancioglu, Rümeyza; Wang, Angela Yee-Moon; Yang, Chih-Wei; Zemchenkov, Alexander; Zhao, Ming-Hui; Jager, Kitty J; Caskey, Fergus; Perkovic, Vlado; Jindal, Kailash K; Okpechi, Ikechi G; Tonelli, Marcello; Feehally, John; Harris, David C; Johnson, David W; KAZANCIOĞLU, RÜMEYZA
    Background. Health information systems (HIS) are fundamental tools for the surveillance of health services, estimation of disease burden and prioritization of health resources. Several gaps in the availability of HIS for kidney disease were highlighted by the first iteration of the Global Kidney Health Atlas. Methods. As part of its second iteration, the International Society of Nephrology conducted a cross-sectional global survey between July and October 2018 to explore the coverage and scope of HIS for kidney disease, with a focus on kidney replacement therapy (KRT). Results. Out of a total of 182 invited countries, 154 countries responded to questions on HIS (85% response rate). KRT registries were available in almost all high-income countries, but few low-income countries, while registries for non-dialysis chronic kidney disease (CKD) or acute kidney injury (AKI) were rare. Registries in high-income countries tended to be national, in contrast to registries in low-income countries, which often operated at local or regional levels. Although cause of end-stage kidney disease, modality of KRT and source of kidney transplant donors were frequently reported, few countries collected data on patient-reported outcome measures and only half of low-income countries recorded process-based measures. Almost no countries had programs to detect AKI and practices to identify CKD-targeted individuals with diabetes, hypertension and cardiovascular disease, rather than members of high-risk ethnic groups. Conclusions. These findings confirm significant heterogeneity in the global availability of HIS for kidney disease and highlight important gaps in their coverage and scope, especially in low-income countries and across the domains of AKI, non-dialysis CKD, patient-reported outcomes, process-based measures and quality indicators for KRT service delivery.
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    Alteration of inflammation marker levels with alfa keto analogs in diabetic rats.
    (2022-09-01T00:00:00Z) Bildaci, Y D; Bulut, H; Elcioglu, O C; Gursu, M; Kazancioglu, Rümeyza; GÜRSU, MELTEM; KAZANCIOĞLU, RÜMEYZA
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    Doğru Kan Basinci Ölçümü İçin İki Yöntemin Karşilaştirilmasi: Manuel Ölçüm Ve Otomatik Cihaz İle Ölçüm.
    (2021-10-13T00:00:00Z) KUŞDOĞAN, ENES; ARTAN, AYŞE SERRA; GÜRSU, MELTEM; MİRİOĞLU, ŞAFAK; KAZANCIOĞLU, RÜMEYZA; ELÇİOĞLU, ÖMER CELAL; KAZANCIOĞLU, RÜMEYZA; ELÇİOĞLU, ÖMER CELAL
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    TRENDS OF PRIMARY GLOMERULAR DISEASE IN TURKEY FROM 2009-2017: A REGIONAL REGISTRY REPORT FROM TSN-GOLD WORKING GROUP
    (2020-06-09T00:00:00Z) GÜL, CUMA BÜLENT; KÜÇÜK, MEHMET; ÖZTÜRK, SAVAŞ; DEMİR, EROL; EREN, NECMİ; SUMNU, ABDULLAH; SEYAHİ, NURHAN; GÜLLÜLÜ, MUSTAFA; DEDE, FATİH; DERİCİ, ÜLVER; KOÇ, YENER; ŞAHİN, GARİP; OYMAK, OKTAY; ŞAHİN, GÜLİZAR; TATAR, ERHAN; DURSUN, BELDA; DHEİR, HAMAD; APAYDIN, SÜHEYLA; SÜLEYMANLAR, GÜLTEKİN; ULU, MEMNUNE SENA; ALTUNÖREN, ORÇUN; KUTLAY, SİM; MEŞE, MERAL; ŞAHİN, İDRİS; ÜSTÜNDAĞ, SEDAT; TÜRKMEN, KÜLTİGİN; YILMAZ, MEHMET EMİN; KAZANCIOĞLU, RÜMEYZA; UZUN, ÖZCAN; CANDAN, FERHAN; AYDIN, MEHMET ZEKİ; OYGAR, DURİYE DEREN; AKTAŞ, NİMET; ERDEM, YUNUS; PAYDAŞ, SAİME; TAYMAZ, DİLEK; CAN, BAŞAK; KIYKIM, AHMET ALPER; KOÇ, LEYLA; SEZER, SİREN; DURANAY, MURAT; BARDAK, SİMGE; ALTINTEPE, LÜTFULLAH; KAYA, BURCU; AZAK, ALPER; ALIŞIR ECDER, SABAHAT; ÇAVDAR, CANER; SELÇUK, NEDİM YILMAZ; KAZANCIOĞLU, RÜMEYZA
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    Otozomal Dominant Polikistik Böbrek Hastalarında Üriner Sistem Taşı Oluşumuna Eğilim Oluşturan Metabolik Faktörler
    (2021-10-13T00:00:00Z) Chasan, Onour; Artan, Ayşe Serra; Gürsu, Meltem; Mirioğlu, Şafak; Kazancıoğlu, Rümeyza; Elçioğlu, Ömer Celal; CHASAN, ONOUR; GÜRSU, MELTEM; MİRİOĞLU, ŞAFAK; KAZANCIOĞLU, RÜMEYZA; ELÇİOĞLU, ÖMER CELAL