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GEÇER, MELİN

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MELİN
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GEÇER
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Author: Gecer, Melin ×

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    Effect of local bleomycin sulfate application on seroma formation in a rat mastectomy and axillary lymph node dissection model
    (2014-01-15T00:00:00Z) Eser, Mehmet; Gokceimam, Mehmet; Eyvaz, Kemal; Tutal, Firat; Gecer, Melin; Goktas, Selcuk; Uzun, Huseyin; Kaptanoglu, Levent; Kurt, N.; GEÇER, MELİN
    Seroma formation is one of the most common complications following breast cancer surgery. It may lead to delay of adjuvant therapies and increasement of therapy costs. Bleomycin sulfate is a sclerosing antibiotic with antineoplastic efficacy. It is locally used in the treatment of pleural effusion. The present study aimed to investigate seroma-reducing effect of local bleomycin application after mastectomy. Sixteen female Wistar Albino rats were used in this study. The rats were divided into two equal groups. Under general anesthesia all rats underwent unilateral mastectomy as definition by Harada. Serum physiologic was applied to animals in Group 1 (control group) and bleomycin to Group 2. Mastectomized localization was explored on the 10th day postoperatively. Seroma and tissue samples were obtained from axilla and thoracic wall for histopathological examination. The amount of seroma was significantly lower in the bleomycin group as compared to the control group (P = 0.002). Fibrosis, PNL infiltration and the number of fibroblasts were significantly higher in the bleomycin group. No difference was identified between the groups in terms of angiogenesis, edema, congestion, and monocyte, lymphocyte and macrophage infiltration. Local bleomycin sulfate application might be a therapeutic option in patients with seroma formation, as well as in the patients with malignant pleural effusion. Nonetheless, further studies that compare the efficacy and adverse effects (benefit-to-harm ratio) of bleomycin sulfate are needed. (C) 2013 Elsevier B.V. All rights reserved,
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    Association between human papillomavirus and endometrial adenocarcinoma
    (2013-09-01T00:00:00Z) Karadayi, Nimet; Gecer, Melin; Kayahan, Sibel; Yamuc, Elif; Onak, Nilufer Kandemir; Korkmaz, Taner; Yavuzer, Dilek; GEÇER, MELİN
    Several studies have suggested a possible role of human papillomavirus (HPV) in the pathogenesis of endometrial carcinoma. The aim of the study was to investigate the presence of HPV DNA in endometrium cancers and nonneoplastic endometrium. Sixty endometrial adenocarcinomas with and without squamous differentiation and the nonneoplastic endometrium tissue of fifty-six of the same patients were analyzed for the presence of family 16 and family 6 HPV DNA by using chromogenic in situ hybridization technique on formalin-fixed and paraffin-embedded archival samples, and the results were confirmed by polymerase chain reaction method. HPV DNA was not detected either in the endometrial adenocarcinoma with or without squamous differentiation, or in the nonneoplastic endometrium tissue. It appears that HPV does not play any role in the pathogenesis of endometrial carcinoma, since endometrium may not to be a suitable host for HPV replication.
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    Effects of local phenytoin on seroma formation after mastectomy and Axillary lymph node dissection: an experimental study on mice
    (2012-12-19T00:00:00Z) Eser, Mehmet; Tutal, Firat; Kement, Metin; Goktas, Selcuk; Kaptanoglu, Levent; Gokceimam, Mehmet; Gecer, Melin; Uzun, Huseyin; GEÇER, MELİN
    Background: Seroma formation is the most common complication after breast cancer surgery. It is an important complication since it prolongs therapy duration, increases cost, and negatively affects patient psychology. Currently, there is no widely accepted method that prevents seroma formation. We tried to investigate impact of local phenytoin application on seroma formation following an experimental mastectomy model created in rats.
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    A prospective comparative study to assess the contribution of radioisotope tracer method to dye-only method in the detection of sentinel lymph node in breast cancer
    (2013-04-25T00:00:00Z) Eser, Mehmet; Kement, Metin; Kaptanoglu, Levent; Gecer, Melin; Abamor, Evrim; Tutal, Firat; Balin, Salim; Kurt, Necmi; Uzun, Huseyin; GEÇER, MELİN
    Background: Metastasis in the axillary lymph nodes is the most important known prognostic factor for breast cancer. We aimed to investigate the contribution of the radioisotope tracer method to the dye-only method by performing sentinel lymph node biopsy on the same patient group during a single surgical session.