Person:
HATİBOĞLU, MUSTAFA AZİZ

Profile Picture
Google ScholarScopusORCIDPublons
Status
Organizational Units
OrgUnit Logo
Organizational Unit
Job Title
First Name
MUSTAFA AZİZ
Last Name
HATİBOĞLU
Name
Email Address
Birth Date

Filters

2018 - 201942020 - 20213
Reset filters

Settings

Type: Article × Author: KOÇYİĞİT, ABDÜRRAHİM ×

Search Results

Now showing 1 - 7 of 7
  • No Thumbnail Available
    PublicationMetadata only
    Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3
    (2019-01-01) HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; Akdur, Kerime; Khan, Imran; Nalli, Arife; Karataş, Ersin; TÜZGEN, SAFFET; HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KHAN, IMRAN
    BACKGROUND: Patients with brain metastasis from melanoma have a dismal prognosis with poor survival time. Gamma Knife (GK) is an effective treatment to control brain metastasis from melanoma. Thymoquinone (TQ) has emerged as a potential therapeutic option due to its antiproliferative effects on various cancers. The purpose of the study was to assess the effect of GK on B16-F10 melanoma cells in vitro and intracerebral melanoma in vivo, and its synergistic effect in combination with TQ.
  • No Thumbnail Available
    PublicationMetadata only
    The effect of high mobility group box-1 protein on cerebral edema, blood-brain barrier, oxidative stress and apoptosis in an experimental traumatic brain injury model
    (2020-01-01T00:00:00Z) Hatiboglu, Mustafa Aziz; Evran, Sevket; Calis, Fatih; Akkaya, Enes; Baran, Oguz; Cevik, Serdar; Katar, Salim; Gurevin, Ebru Gurel; Hanimoglu, Hakan; Armutak, Elif Ilkay; Karatas, Ersin; KOÇYİĞİT, ABDÜRRAHİM; Kaynar, Mehmet Yasar; HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM
  • Thumbnail Image
    PublicationOpen Access
    Thymoquinone ameliorates delayed cerebral injury and cerebral vasospasm secondary to experimental subarachnoid haemorrhage.
    (2020-11-30T00:00:00Z) Koçyiğit, A; Evran, Ş; Çalış, F; Çevik, S; Katar, S; Karataş, E; Sağlam, MY; Hatiboğlu, MUSTAFA AZİZ; Hanımoğlu, H; Kaynar, MY; KOÇYİĞİT, ABDÜRRAHİM; HATİBOĞLU, MUSTAFA AZİZ
  • No Thumbnail Available
    PublicationMetadata only
    Gamma knife radiosurgery compared to whole brain radiation therapy enhances immunity via immunoregulatory molecules in patients with metastatic brain tumours.
    (2019-07-18) Hatiboglu, MA; Kocyigit, A; Guler, Eray Metin; Nalli, A; Akdur, K; Sakarcan, A; Mayadagli, A; Uysal, O; HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; ÖZEK, ERDİNÇ; UYSAL, ÖMER; MAYADAĞLI, ALPASLAN
    Background: There is lack of data on the effect of stereotactic radiosurgery in modulation of the immune system for cancer patients with metastatic brain tumours. Therefore, we investigated the change in levels of immunoregulatory molecules after Gamma Knife radiosurgery (GKR) and whole brain radiation therapy (WBRT) in patients with brain metastases. Methods: Peripheral blood samples were collected from 15 patients who received GKR, nine patients who received WBRT for brain metastases and 10 healthy controls. Samples were obtained at three time points such as before, 1h after and 1 week after the index procedure for patients treated with GKR or WBRT. All patients- demographic data and radiosurgical parameters were retrospectively reviewed. We analyzed the change in the levels of T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death ligand-1 (PD-L1), and cytokines such as IL-2, IL-10, IFN-gamma, TNF-alpha after GKR and WBRT using Enzyme-linked immunosorbent assays (ELISA). Results: Baseline level of IFN-gamma was found to be lower and that of PD-L1 was higher in the GKR group compared to WBRT group and healthy controls (p < 0.05 and p < 0.01, respectively). Levels of IFN-gamma and IL-2 were increased (p < 0.01 and p < 0.01, respectively), while CTLA-4 and PD-L1 were decreased (p = 0.05 and p = 0.01, respectively) after GKR compared to pre-GKR levels, while there was no change after WBRT. Conclusion: GKR regulates immunoregulatory molecules towards enhancing the immune system, while WBRT did not exert any effect. These findings suggested that treatment of metastatic brain lesion with GKR might stimulate a systemic immune response against the tumour.
  • No Thumbnail Available
    PublicationMetadata only
    Effects of Intrathecai Verapamil on Cerebral Vasospasm in Experimental Rat Study
    (2019-07-01T00:00:00Z) Hatiboglu, Mustafa Aziz; Evran, Sevket; Calis, Fatih; Cevik, Serdar; Hanimoglu, Hakan; SEYİTHANOĞLU, MEHMET HAKAN; Katar, Salim; Karatas, Ersin; KOÇYİĞİT, ABDÜRRAHİM; Saglam, Mustafa Yasin; Kaynar, Mehmet Yasar; SEYİTHANOĞLU, MEHMET HAKAN; KOÇYİĞİT, ABDÜRRAHİM; HATİBOĞLU, MUSTAFA AZİZ
    BACKGROUND: Verapamil a calcinarn channel blacker, has shown promising results on cerebral vasospasm. However, it has not yet been accepted for treatment or prevention purposes because of the associated side effects, Although the effective results of nimodipine and nicardipine-s intrathecal administration are well known, intrathecal verapamil has not been considered earlier. We used an experimental subarachnoid hemorrhage induced vasospasm model for the evaluation of vasodilator and neuroprotective effects of intrathecal verapamil,
  • Thumbnail Image
    PublicationOpen Access
    Investigation of cellular effects of thymoquinone on glioma cell
    (2021-01-01T00:00:00Z) Guler, Eray Metin; ŞİŞMAN, Behice Hande; KOÇYİĞİT, ABDÜRRAHİM; HATİBOĞLU, MUSTAFA AZİZ; ŞİŞMAN, BEHİCE HANDE; KOÇYİĞİT, ABDÜRRAHİM; HATİBOĞLU, MUSTAFA AZİZ
    Glioblastoma, as an invasive tumor, is one of the most common primary malignant brain tumors. Despite maximum aggressive treatment, patients with glioblastoma have a dismal prognosis. Thymoquinone (TQ) has been found to show anti-cancer effects on different types of cancer. There are a few in vitro studies on the effect of TQ on glial tumors. However, the molecular mechanism of TQ-s anti-cancer effect has not been fully elucidated. In the present study, we aimed to investigate the genotoxic, apoptotic, and cytotoxic effects of TQ on C6 rat glioma cells. C6 glioma cells were analyzed after 24 h of exposure to different concentrations of TQ by the ATP cell viability assay for cytotoxicity, comet assay for genotoxicity, 2′,7′dichlorodihydrofluorescein diacetate (H2DCF-DA) for intracellular reactive oxygen species (iROS) generation, 3.3′dihexyloxacarbocyanine iodide (DiOC6(3)) for mitochondrial membrane potential, GSH/GSSG-Glo Assay for glutathione level and Fura-2AM for intracellular calcium levels. Apoptosis induction was studied by acridine orange/ethidium bromide double staining, flow cytometry, and western blotting analyses. Caspase-3, Caspase-9, Bax, Bcl-2, and pSTAT3 protein levels were determined by the western blotting method. Cytotoxicity was enhanced by TQ in C6 glioma cells in a concentration-dependent manner. TQ also induced DNA damage, apoptosis, and increased iROS. Also, MMP and GSH levels were decreased by TQ. It inhibited pSTAT3, resulting in apoptosis induction through the regulation of anti-apoptotic and pro-apoptotic proteins. Our results suggest that TQ would be an effective treatment in glioma. Further studies should support these findings.
  • No Thumbnail Available
    PublicationMetadata only
    Thymoquinone Induces Apoptosis in B16-F10 Melanoma Cell Through Inhibition of p-STAT3 and Inhibits Tumor Growth in a Murine Intracerebral Melanoma Model
    (2018-06-01) HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; AKDUR, Kerime; NALLI, Arife; KARATAŞ, Ersin; TUZGEN, Saffet; HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN