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GÜRSES, HÜLYA NILGÜN

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Author: GÜRSES, HÜLYA NILGÜN × Subject: Sit-to-stand test ×

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    PublicationOpen Access
    Sit-to-stand test in children with bronchiectasis: Does it measure functional exercise capacity?
    (2020-09-01T00:00:00Z) Zeren, Melih; Gürses, Hülya Nilgün; Denizoğlu Külli, Hilal; Uçgun, Hikmet; Çakır, Erkan; GÜRSES, HÜLYA NILGÜN; DENİZOĞLU KÜLLİ, HİLAL; UÇGUN, HİKMET; ÇAKIR, ERKAN
    Background Similar to six-minute walk test (6MWT), sit-to-stand test (STST) is a self-paced test which elicits sub-maximal effort; therefore, it is suggested as an alternative measurement for functional exercise capacity in various pulmonary conditions including COPD and cystic fibrosis. We aimed to investigate the association between 30-second STST (30s-STST) and 6MWT in both children with bronchiectasis (BE) and their healthy counterparts, as well as exploring cardiorespiratory burden and discriminative properties of both tests. Methods Sixty children (6 to 18-year-old) diagnosed with non-cystic fibrosis BE and 20 age-matched healthy controls were included. Both groups performed 30s-STST and 6MWT. Test results, and heart rate, SpO2 and dyspnea responses to tests were recorded. Results Univariate analysis revealed that 30s-STST was able to explain 52% of variance in 6MWT (r = 0.718, p<0.001) in BE group, whereas 20% of variance in healthy controls (r = 0.453, p = 0.045). 6MWT elicited higher changes in heart rate and dyspnea level compared to 30s-STST, indicating it was more physically demanding. Both 30s-STST (21.65±5.28 vs 26.55±3.56 repetitions) and 6MWT (538±85 vs 596±54 m) were significantly lower in BE group compared to healthy controls (p<0.01). Receiver operating characteristic (ROC) curve analysis revealed an area under the ROC curve (UAC) of 0.765 for 30s-STST and 0.693 for 6MWT in identifying the individuals with or without BE (p<0.05). Comparison between AUCs of 30s-STST and 6MWT yielded no significant difference (p = 0.466), indicating both tests had similar discriminative properties. Conclusions 30s-STST is found to be a valid alternative measurement for functional exercise capacity in children with BE.
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    PublicationOpen Access
    Cut-off values of 6-min walk test and sit-to-stand test for determining symptom burden in atrial fibrillation
    (2022-01-01T00:00:00Z) Zeren, Melih; Karci, Makbule; DEMİR, Rengin; GÜRSES, Hülya Nilgün; OKTAY, Veysel; UZUNHASAN, Işıl; YİĞİT, Zerrin; GÜRSES, HÜLYA NILGÜN
    Background Since symptomatology is a major predictor of quality of life and an endpoint for the management of atrial fbrillation (AF), practical approaches for objectively interpreting symptom burden and functional impairment are needed. Aims We aimed to provide cut-of values for two frequently used feld tests to be able to objectively interpret symptom burden in atrial fbrillation. Methods One hundred twenty-fve patients with AF were evaluated with European Heart Rhythm Association (EHRA) score, 6-min walk test (6MWT), 30 s sit-to-stand test (30 s-STST), Short-Form 36 (SF-36), International Physical Activity Questionnaire-Short Form (IPAQ-SF), and spirometry. Patients with EHRA 1 were classifed as “asymptomatic”, and those with EHRA 2–4 as “symptomatic”. Cut-of values of 6MWT and 30 s-STST for discriminating between these patients were calculated. Results The optimal cut-of value was “450 m” for 6MWT (sensitivity: 0.71; specifcity of 0.79) and “11 repetitions” for 30 s-STST (sensitivity 0.77; specifcity of 0.70). Area under ROC curve was 0.75 for both tests (p<0.001). Subgroup analysis revealed patients below cut-of values also had worse outcomes in SF-36, IPAQ-SF, and spirometry. Conclusions In patients with AF, walking < 450 m in 6MWT or performing < 11 repetitions in 30 s-STST indicates increased symptom burden, as well as impaired exercise capacity, quality of life, physical activity participation, and pulmonary function. These cut-of values may help identifying patients who may require adjustments in their routine treatment or who may beneft from additional rehabilitative approaches.