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YILDIRIM, YAVUZ SELİM

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YAVUZ SELİM
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Author: AKSOY, FADLULLAH ×

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    Eustachian Tube Function in Patients Receiving Continuous Positive Airway Pressure Treatment for Sleep Apnea Syndrome
    (2010-12-01) AKSOY, Fadlullah; Yildirim, YAVUZ SELİM; Ozturan, ORHAN; VEYSELLER, Bayram; Cuhadaroglu, Caglar; AKSOY, FADLULLAH; YILDIRIM, YAVUZ SELİM; ÖZTURAN, ORHAN
    Objective: We evaluated eustachian tube (ET) function in patients using continuous positive airway pressure (CPAP).
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    Tension pneumocephalus: an extremely small defect leading to an extremely serious problem
    (2013-11-01) Aksoy, Fadlullah; Dogan, REMZİ; Ozturan, ORHAN; TUGRUL, Selahattin; Yildirim, YAVUZ SELİM; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; YILDIRIM, YAVUZ SELİM
    Background: Pneumocephalus is a pathology characterized by air influx into the intracranial region. It may occur after head trauma and rarely after endoscopic sinus surgery. As the amount of air increases, this can cause neurological disorders with a mass effect and this condition is called tension pneumocephalus.
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    The Effect of Topical Cefepime Solution on Outer Hair Cell Function of Rats
    (2011-01-01) Apuhan, Tayfun; Yildirim, YAVUZ SELİM; Aksoy, Fadlullah; BALIKCI, Hasan Huseyin; Kaya, Mehmet Onur; YILDIRIM, YAVUZ SELİM; AKSOY, FADLULLAH
    Objectives: The current study was designed to investigate the ototoxic effect of topical cefepime solution on the outer cell function of cochlea by measuring distortion product otoacoustic emission (DPOAE) amplitudes.
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    [Distortion product otoacoustic emissions results in children with middle ear effusion]. Seröz otitis mediali çocuklarda distorsiyon ürünü otoakustik emisyon sonuçlari.
    (2010-01-01T00:00:00Z) AKSOY, Fadlullah; Yildirim, YAVUZ SELİM; VEYSELLER, Bayram; DEMIRHAN, Hasan; Ozturan, ORHAN; AKSOY, FADLULLAH; YILDIRIM, YAVUZ SELİM; ÖZTURAN, ORHAN
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    PublicationOpen Access
    Otoacoustic Emission Responses of the Cochlea to Acute and Total Ischemia
    (2013-12-01) Yildirim, YAVUZ SELİM; AKSOY, Fadlullah; Ozturan, ORHAN; VEYSELLER, Bayram; DEMIRHAN, Hasan; YILDIRIM, YAVUZ SELİM; AKSOY, FADLULLAH; ÖZTURAN, ORHAN
    In the present experimental study, we sought to monitor distortion product otoacoustic emissions (DPOAEs) as an indicator of cochlear function, after sudden, total, and irreversible interruption of cochlear blood flow, to provide information on the time course of cochlear response to ischemia. Twenty rats with normal hearing function were included. Complete and abrupt ischemia was provided by decapitation. DPOAEs at 3–8 kHz frequencies were recorded at baseline and exactly every consecutive minute after decapitation, until emissions in all frequencies disappeared completely. Mean DPOAE values decreased significantly and progressively after decapitation for all frequencies. The mean duration of emissions was 8.20 ± 1.96 min (minimum 3 min, maximum 11 min). The longest durations of DPOAEs were observed with 4 and 5 kHz frequencies, and 3 and 6 kHz had the shortest durations. The outer hair cells exposed to acute ischemia seem to exhibit a rapid functional loss; thus, cautious handling of the cochlear vasculature and surrounding structures is necessary in surgical interventions. Additionally, our results provide some idea of the normal tolerance range of the cochlea to ischemia, which could be useful for future studies
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    [Patterns of cervical metastasis from squamous cell carcinoma of the head and neck]. Baş ve boyun yassi epitel hücreli kanserlerinde boyun yayilim modelleri.
    (2010-01-01T00:00:00Z) AKSOY, Fadlullah; VEYSELLER, Bayram; BINAY, Omer; APUHAN, Tayfun; Yildirim, YAVUZ SELİM; Ozturan, ORHAN; AKSOY, FADLULLAH; YILDIRIM, YAVUZ SELİM; ÖZTURAN, ORHAN
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    Reduced olfactory bulb volume and diminished olfactory function in total laryngectomy patients: A prospective longitudinal study
    (2012-05-01) VEYSELLER, Bayram; OZUCER, Berke; AKSOY, Fadlullah; Yildirim, YAVUZ SELİM; GURBUZ, Defne; BALIKCI, Hasan Huseyin; Ozturan, ORHAN; AKSOY, FADLULLAH; YILDIRIM, YAVUZ SELİM; ÖZTURAN, ORHAN
    Background: This study was designed to investigate the effects of total laryngectomy on olfactory bulb (OB) volume and olfactory function prospectively. A prospective, longitudinal, randomized study was performed.
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    Betahistine Exacerbates Amikacin Ototoxicity
    (2015-04-01) AKSOY, Fadlullah; Dogan, REMZİ; Ozturan, ORHAN; Yildirim, YAVUZ SELİM; VEYSELLER, Bayram; Yenigun, ALPER; OZTURK, Burak; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; YILDIRIM, YAVUZ SELİM; YENİGÜN, ALPER
    Objective: Betahistine augments cochlear blood flow and is currently used as an efficient therapeutic agent. Amikacin is used in a wide range of areas, but its ototoxic effect continues to be problematic. This study investigates the effect of betahistine on amikacin-induced ototoxicity.
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    Effect of nasal antihistamine on secretory IgA in nasal lavage of rats
    (2018-01-01) Dogan, REMZİ; AKSOY, Fadlullah; Goktas, Seda Sezen; Kocak, Ilker; Yildirim, YAVUZ SELİM; Incir, Said; Ozturan, ORHAN; DOĞAN, REMZI; AKSOY, FADLULLAH; YILDIRIM, YAVUZ SELİM; ÖZTURAN, ORHAN
    The humoral IgA is an immunoglobulin which plays a defensive role for organisms on mucosal surfaces. Today, intranasal antihistamines are effectively used in the treatment of allergic rhinitis. In our study, the effect of azelastine hydrochloride-a nasal antihistaminic-on humoral IgA of the nasal mucosa has been reviewed empirically. Twenty-four female Sprague-Dawley rats were included in our study. The rats were divided into three groups randomly. Group 1(azelastine hydrochloride): rats in this group had nasal azelastine hydrochloride (0.05%) applied for 30 days at 10 A mu l/nostril dosage. Group 2 (saline): saline (0.09%) was applied to the rats in this group for 30 days at 10 A mu l/nostril dosage. Group 3 (control): no application was made throughout the study. The chemicals applied in Groups 1 and 2 were applied to both nostrils by mounting a flexible micropipette to the end of an insulin injector. At the beginning of the study, nasal lavage was performed to both nostrils of the rats in every group on the 15th and 30th day to aspirate irrigation solution (distilled water). The aspirated liquids were kept at - 80A degrees temperature and reviewed together at the end of study. Within-group comparisons: in Group 1 (azelastine hydrochloride), the humoral IgA value on the 15th day was significantly higher than the basal value (p = 0.037). There is a significant difference between humoral IgA value on the 30th day and humoral IgA value on the 15th day (p = 0.045). In Group 2 (saline), no significant difference is available between basal, 15th day and 30th day humoral IgA values (p = 0.265). In Group 3 (control), no significant difference is available between basal, 15th day and 30th day humoral IgA values (p = 0.374). Between-group comparison: there is no significant difference in between-group humoral IgA basal values (p = 0.714). On days 15 and 30, Humoral IgA value of Group 1 was significantly higher than that of Groups 2 and 3 (p = 0.013, p = 0.024, respectively). According to the results we achieved in our study, nasal antihistaminic (azelastine hydrochloride) significantly increases the level of humoral IgA. Our study is the first one in the literature to reveal a relation between nasal antihistaminic and humoral IgA and there is a further need for clinical, randomized and prospective studies.
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    PublicationOpen Access
    Olfactory Dysfunction and Olfactory Bulb Volume Reduction in Patients with Leprosy
    (2012-09-01) VEYSELLER, Bayram; AKSOY, Fadlullah; Yildirim, YAVUZ SELİM; ACIKALIN, R. Murat; GURBUZ, Defne; Ozturan, ORHAN; AKSOY, FADLULLAH; YILDIRIM, YAVUZ SELİM; ÖZTURAN, ORHAN
    To ascertain the level and rate of olfactory dysfunction in patients with leprosy and to determine whether olfactory bulb volume is affected by the pathophysiology. Olfactory bulb (OB) volume, measured using magnetic resonance imaging (MRI), was compared in 15 patients with leprosy and 15 healthy controls. All of the participants were evaluated using a detailed history to identify the probable causes of the smell dysfunction. Those who had a disease other than leprosy that may have caused the smell dysfunction were excluded from the study. OB volumes were calculated by manually tracing the OB on coronal sections. Orthonasal olfaction testing was used to assess smell function. The orthonasal olfaction testing indicated that all patients with leprosy were anosmic or severely hyposmic. The smell function test indicated that the OB volume of the patient group was significantly lower than that of the control group. No within-group difference was detected between right and left OB volume in either group. The patients in the leprosy group were severely hyposmic or anosmic and their olfactory bulb volume was significantly lower than that of the control group. To our knowledge, this study is the first to show a reduction in olfactory bulb volume among leprosy patients.