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ÖZKAYA, EMİN

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EMİN
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ÖZKAYA
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2012 - 20142
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Subject: Asthma ×

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Now showing 1 - 2 of 2
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    PublicationOpen Access
    Osteocalcin, Cortisol Levels, and Bone Mineral Density in Prepubertal Children with Asthma Treated with Long-Term Fluticasone Propionate
    (2012-01-01) Ozkaya, EMİN; NURSOY, Mustafa A.; Erenberk, UFUK; Cakir, ERKAN; ÖZKAYA, EMİN; NURSOY, MUSTAFA ATİLLA; UZUNER, SELÇUK; ERENBERK, UFUK; ÇAKIR, ERKAN
    Aims: The objective of this study is to determine the effects of the long-term treatment with inhaled fluticasone propionate on osteocalcin, cortisol levels, and bone mineral status in children with asthma. Methods: This cross-sectional study examined 230 prepubertal children with asthma (aged 6–11) who had intermittently used inhaled fluticasone propionate for at least 5 years at a mean daily dose of 200 μg (range: 200-350 μg). Serum osteocalcin, cortisol, and bone mineral density (BMD) of the lumbar spine were obtained from each participant. The control group consisted of gender- and age-matched children (n = 170) who were newly diagnosed with asthma and who were not being treated with corticosteroid. Results: The average age (± SEM) was 8.9 ± 0.7 years, their mean (± SEM) daily steroid dose was 180.3 ± 55.0 μg, with 236.5 ± 17.2 g total steroid use during treatment. Between the study and the control groups, no significant differences were observed in cortisol, osteocalcin levels, and BMD (p > 0.05). Conclusion: Long-term treatment with inhaled fluticasone propionate (100 μg twice daily) revealed no negative effects on serum osteocalcin, cortisol levels, and BMD in children with asthma.
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    PublicationOpen Access
    The Effect of Risk Factors on Quality of Life in Childhood Asthma
    (2014-03-01T00:00:00Z) ÖZKAYA, EMİN; Sancar, Ozgur; Dundaroz, Mehmet Rusen; ÖZKAYA, EMİN
    Objective: This study was conducted to assess the Quality of Turkish children with asthma and its associated risk factors by using the PAQLQ (Pediatric Asthma Quality Of Life Questionnaire). Methods: One hundred fifty children with asthma aged between 7-17 who were attending the out-patient clinic of the Pediatric Allergy and Immunology section were selected for the study between March 2009-March 2011. Asthma severity was made according to the Global Initiative for Asthma-GINA. Quality of Life (QoL) was measured by the Turkish version of the Pediatric Asthma Quality Of Life Questionnaire (PAQLQ). A total QoL score was calculated by the mean of all items. Patients' PAQLQ sores of different levels of disease were analyzed by ANOVA. Results: One hundred fifty (93 boys) children were included in our study. The mean time since asthma diagnosis was 6.5 years (+/- 2.8). There were statistically significant PAQLQ score differences among children with mild, moderate, and severe asthma (p<0.001). There was a negative inverse relation between passive exposure of smoking and the number of family member and PAQLQ sores. PAQLQ sores of children who also had allergic rhinitis symptoms were significantly lower than those who had no allergic rhinitis symptoms Conclusion: This study showed that children with asthma have significantly low QoL scores. Passive cigarette exposure and additional allergic rhinitis affect PAQLQ scores negatively.