Person:
ÖZKAYA, EMİN

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Kurumdan Ayrılmıştır

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Organizational Unit

Tıp Fakültesi

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EMİN

Last Name

ÖZKAYA

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Now showing 1 - 10 of 12

Open Access
Evaluation of 563 children with chronic cough accompanied by a new clinical algorithm
(2015-10-06) GEDIK, Ahmet Hakan; BAHALI, Kayhan; KUCUKKOC, Mehmet; NURSOY, Mustafa; GOKCE, Selim; Cakir, ERKAN; Ozkaya, EMİN; Uzuner, SELÇUK; Erenberk, UFUK; Torun, EMEL; DEMIR, Aysegul Dogan; AKSOY, Fadlullah; ÇAKIR, ERKAN; TORUN, EMEL; ERENBERK, UFUK; UZUNER, SELÇUK; NURSOY, MUSTAFA ATİLLA; ÖZKAYA, EMİN; AKSOY, FADLULLAH
Background: This study aims to evaluate the children with chronic cough and to analyze their etiological factors according to the age groups. Method: Five hundred sixty-three children with chronic cough were included. The last diagnosis were established and were also emphasized according to the age groups. Results: The mean age was 5.4 ± 3.8 years (2-months–17-years) and 52 % of them were male. The most common final diagnosis from all the participants were: asthma (24.9 %), asthma-like symptoms (19 %), protracted bacterial bronchitis (PBB) (11.9 %), and upper airway cough syndrome (9.1 %). However, psychogenic cough was the second most common diagnosis in the subjects over 6 years of age. Conclusion: Asthma and asthma-like symptoms were the most common diagnosis in children. Different age groups in children may have a different order of frequencies. Psychogenic cough should be thought of in the common causes especially in older children.
Open Access
Can appropriate diagnosis and treatment of childhood asthma reduce excessive antibiotic usage?
(2014-01-01) GEDIK, AH; Cakir, ERKAN; OZKAYA, EMİN; ARI, E; NURSOY, MUSTAFA ATİLLA; ÇAKIR, ERKAN; ÖZKAYA, EMİN; NURSOY, MUSTAFA ATİLLA
Introduction: This study compared the frequency of antibiotic usage and the number of asthma episodes before and after the diagnosis and treatment of pediatric asthma patients who were followed up by specialists. Subjects and Methods: Included in this study were 334 patients (211 males and 123 females) of 2-16 years of age who were diagnosed with asthma and followed up for at least 1 year in our clinic. The frequency of antibiotic usage and the number of asthma episodes in the year prior to diagnosis and treatment were compared to these same variables after 1 year of follow-up by specialists. Results: The median age was 84 months (range: 24-192) and 212 (63%) children were at school or in day care centers. Atopy and a family history of asthma were present in 200 (60%) of the patients, and 137 (41%) reported that at least one member of their household smoked. Antibiotics were used a median number of 7 times [interquartile range (IQR) = 6] in the year before the asthma diagnosis, and 2 times (IQR = 3) during the year after treatment (p < 0.001). The mean number of asthma episodes before diagnosis, i.e. 4 (IQR = 8) was reduced to 0 (IQR = 2) in the year after treatment when the patients were followed up by specialists (p < 0.001). Conclusion: This study shows that appropriate diagnosis and treatment of childhood asthma significantly reduce the frequency of antibiotic usage and the number of asthmatic episodes.
Open Access
Enuresis Nocturna in children with asthma: prevalence and associated risk factors
(2016-06-01T00:00:00Z) ÖZKAYA, EMİN; Aydin, Seren Calis; YAZICI, MEBRURE; Dundaroz, Rusen; ÖZKAYA, EMİN; YAZICI, MEBRURE; İŞCAN, AKIN
Background: Enuresis Nocturna (EN) is a common disorders in childhood. Although many different underlying pathophysiological mechanisms have been proposed to explain EN, its etiology is multifactorial. Some reports demonstrate that there is an association between EN and allergic diseases. To study (1) the prevalence of EN in children with asthma, (2) to determine the possible risk factors for EN in asthmatic children.
Open Access
Effect of Montelukast Monotherapy on Oxidative Stress Parameters and DNA Damage in Children with Asthma
(2015-01-01) DILEK, Fatih; Ozkaya, EMİN; Kocyigit, ABDÜRRAHİM; Yazici, MEBRURE; KESGIN, Siddika; GEDIK, Ahmet Hakan; Cakir, ERKAN; ÖZKAYA, EMİN; KOÇYİĞİT, ABDÜRRAHİM; YAZICI, MEBRURE; ÇAKIR, ERKAN
Background: There is ample knowledge reported in the literature about the role of oxidative stress in asthma pathogenesis. It is also known that the interaction of reactive oxygen species with DNA may result in DNA strand breaks. The aim of this study was to investigate if montelukast monotherapy affects oxidative stress and DNA damage parameters in a population of pediatric asthma patients. Methods: Group I consisted of 31 newly diagnosed asthmatic patients not taking any medication, and group II consisted of 32 patients who had been treated with montelukast for at least 6 months. Forty healthy control subjects were also enrolled in the study. Plasma total oxidant status (TOS) and total antioxidant status (TAS) were measured to assess oxidative stress. DNA damage was assessed by means of alkaline comet assay. Results: The patients in both group I and group II had statistically significant higher plasma TOS (13.1 ± 4 and 11.1 ± 4.1 μmol H2O2 equivalent/liter, respectively) and low TAS levels (1.4 ± 0.5 and 1.5 ± 0.5 mmol Trolox equivalent/liter, respectively) compared with the control group (TOS: 6.3 ± 3.5 μmol H2O2 equivalent/liter and TAS: 2.7 ± 0.6 mmol Trolox equivalent/liter; p < 0.05). DNA damage was 18.2 ± 1.0 arbitrary units (a.u.) in group I, 16.7 ± 8.2 a.u. in group II and 13.7 ± 3.4 a.u. in the control group. There were statistically significant differences only between group I and the control group (p < 0.05). Conclusions: According to the findings, montelukast therapy makes only minimal but not statistically significant improvement in all TOS, TAS and DNA damage parameters.
Open Access
Renal tubular function and urinary N-acetyl-beta-d-glucosaminidase and kidney injury molecule-1 levels in asthmatic children
(2016-12-01) DEMIR, Aysegul Dogan; GOKNAR, Nilufer; OKTEM, Faruk; Ozkaya, EMİN; Yazici, MEBRURE; Torun, EMEL; Vehapoglu, Aysel; KUCUKKOC, Mehmet; ÖZKAYA, EMİN; YAZICI, MEBRURE; TORUN, EMEL; VEHAPOĞLU TÜRKMEN, AYSEL
Background: Asthma is a chronic inflammatory disorder of the airways which results in chronic hypoxia. Chronic hypoxia and inflammation can affect renal tubular function. Objectives: The aim of this study was to investigate renal tubular function and early kidney injury molecules such as urinary N-acetyl-betaglucosaminidase (NAG) and kidney injury molecule-1 (KIM-1) excretion in children with asthma. Methods: Enrolled in the study were 73 children diagnosed with asthma and 65 healthy age- and gender-matched control subjects. Urine pH, sodium, phosphorus, potassium, microalbumin, creatinine, NAG, KIM-1, and serum creatinine, sodium, phosphorus were evaluated. The diagnosis of asthma and classification of mild or moderate were done according to the Global Initiative for Asthma guidelines. Results: Serum sodium, phosphorus, creatinine, and urinary microalbumin were within normal levels in the both groups. Urinary pH, sodium, potassium, phosphorus, microalbumin, and KIM-1 excretions were similar between the control and study groups. Tubular phosphorus reabsorption was within normal limits in two groups. Urine NAG was elevated in the study group (P = 0.001). Urinary KIM-1 and NAG levels were positively correlated (r = 0.837; P = 0.001). When children with mild and moderate asthma were compared, all of the parameters were similar (P >0.05). Conclusions: This study showed that chronic asthma can lead to subtle renal impacts. We suggest that in children with asthma, urinary NAG level is a more valuable parameter to show degree of renal tubular injury than markers such as microalbumin and KIM-1. Chronic hypoxy and inflammation probably contributes to these subclinical renal effects.
Open Access
Oxidative Stress in Children with Chronic Spontaneous Urticaria
(2016-01-01) DILEK, Fatih; Ozceker, Deniz; Ozkaya, EMİN; Guler, Nermin; Tamay, Zeynep; KESGIN, Siddika; Yazici, MEBRURE; Kocyigit, ABDÜRRAHİM; ÖZKAYA, EMİN; YAZICI, MEBRURE; KOÇYİĞİT, ABDÜRRAHİM
The pathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood; nevertheless, significant progress has been achieved in recent years. The aim of this study was to investigate the possible role of reactive oxygen species (ROS) in the pathogenesis of CSU. Sixty-two children with CSU and 41 healthy control subjects were enrolled in the study. An extensive evaluation of demographic and clinical features was done, and serum oxidative stress was evaluated by plasma total oxidant status (TOS) and total antioxidant status (TAS) measurements.The median value of plasma TOS was found to be 10.49 𝜇mol H2O2 equiv./L (interquartile range, 7.29–17.65) in CSU patients and 7.68 𝜇mol H2O2 equiv./L (5.95–10.39) in the control group. The difference between the groups was statistically significant (𝑝 = 0.003). Likewise, the median plasma TAS level in the CSU group was decreased significantly compared to that of the control group (2.64 [2.30–2.74] versus 2.76 [2.65–2.86] mmol Trolox equiv./L, resp., 𝑝 = 0,001). Our results indicated that plasma oxidative stress is increased in children with CSU when compared to healthy subjects, and plasma oxidative stress markers are positively correlated with disease activity
Open Access
Total antioxidant status and oxidative stress and their relationship to total IgE levels and eosinophil counts in children with allergic rhinitis.
(2012-05-01) ÖZKAYA, EMİN; ÖZKAYA, EMİN
Background: Oxidative stress may play a role in the pathophysiology of several diseases including allergic rhinitis. Objectives: To evaluate whether plasma total oxidant status (TOS) in the form of plasma reactive oxidants differs between children with allergic rhinitis and healthy controls and to investigate associations between plasma antioxidants and other allergic rhinitis-related immunological markers. Materials and methods: Plasma total antioxidant status (TAS), TOS, total eosinophil count, and total serum immunoglobulin (Ig) E levels were measured in 106 children newly diagnosed with allergic rhinitis and 70 nonallergic children (7-12 years of age). Plasma TAS and TOS were measured using novel automated measurement methods. Blood eosinophils (absolute counts and percentage of total white blood cells) and total IgE were elevated in children with allergic rhinitis after adjusting for age and sex. Results: TAS and TOS were higher in the patient group than in the control group (P<.001 and P<.002, respectively). The association between plasma TAS and TOS and allergic rhinitis status was similar when eosinophils, total IgE, and allergic sensitization were included as possible confounders in logistic regression models. Multivariate logistic regression identified allergic rhinitis as the only independent factor contributing to TOS. Conclusion: Plasma TAS and TOS levels are elevated in children with allergic rhinitis. Moreover, the high level of TOS indicates that these patients are exposed to severe oxidative stress. This stress factor may have a role in the pathogenesis of allergic rhinitis.
Open Access
Pupillometric assessment of autonomic nervous system in children with allergic rhinitis.
(2013-04-01) ÖZKAYA, EMİN; ÖZKAYA, EMİN; ERENBERK, UFUK
Objective: The purpose of this study was to investigate autonomic nervous system dysfunction by measuring pupil sizes in pediatric patients with allergic rhinitis. Subjects and Methods: The study group consisted of 60 children (28 girls and 32 boys) who were age and gender matched with the control group, which also consisted of 60 children (26 girls and 34 boys). The diagnosis of allergic rhinitis was based on the history, physical examination and skin prick test performed by an allergologist. Pupil diameter measurements were performed using the pupillometer incorporated in the NİDEK OPD-Scan. Results: In the allergic rhinitis group, mean photopic and mesopic pupil diameters were 3.52 ± 0.07 and 5.98 ± 0.21, respectively, while in the control group, corresponding measurements were 4.03 ± 0.18 and 6.55 ± 0.16. There was a significant difference for photopic and mesopic pupil diameter between the groups (p < 0.001). Conclusion: This study showed that the pupil size in response to a light stimulus in children with allergic rhinitis was smaller than that of the control group and may indicate parasympathetic hyperactivity and sympathetic hypoactivity.
Open Access
Plasma levels of matrix metalloproteinase-9 in children with Chronic spontaneous urticaria
(2016-01-01) DILEK, Fatih; OZCEKER, Deniz; ÖZKAYA, EMİN; TAMAY, Zeynep; YAZICI, MEBRURE; KESGIN, Siddika; KOÇYİĞİT, ABDÜRRAHİM; GULER, Nermin; ÖZKAYA, EMİN; YAZICI, MEBRURE; KOÇYİĞİT, ABDÜRRAHİM
Purpose: Chronic spontaneous urticaria (CSU) is a disease that is primarily seen in adults and is comparatively rare in children. Consequently, only a few studies have focused on the pathogenesis of the disease in children. This study investigated the possible role of metalloproteinase-9 (MMP-9) in the pathogenesis of CSU in children. Methods: The study group was composed of 54 children with CSU; 34 healthy children comprised the control group. The demographic and clinical features of the study group were extensively evaluated, and laboratory assessments were also performed. An enzyme-linked immunosorbent assay was used to evaluate levels of plasma MMP-9. Disease activity was quantified using the urticaria activity score (UAS). Results: The median value of plasma MMP-9 was 108.9 ng/mL (interquartile range, 93.3-124.1) in the CSU group and 87.8 ng/mL (69.4-103.0) in the control group. The difference between the 2 groups was statistically significant (P<0.001). Also, MMP-9 levels showed a significant positive correlation with UAS (rho=0.57, P<0.001). Twenty-six percent of patients had positive autologous serum skin test (ASST) results. Neither UAS nor plasma MMP-9 levels were significantly different between ASST-positive and -negative patients (P>0.05). Conclusions: Plasma MMP-9 levels were elevated in children with CSU and were positively correlated with disease activity. MMP-9 may be both a good biomarker of disease activity and a potential therapeutic target in CSU.
Open Access
Plasma lipoxin a4 levels in childhood chronic spontaneous urticaria
(2018-01-01) DİLEK, FATİH; ÖZÇEKER, DENİZ; GÜLER, ERAY METİN; ÖZKAYA, EMİN; YAZICI, MEBRURE; TAMAY, ZEYNEP ÜLKER; KOÇYİĞİT, ABDURRAHİM; GÜLER, NERMİN; GÜLER, ERAY METİN; ÖZKAYA, EMİN; YAZICI, MEBRURE; KOÇYİĞİT, ABDÜRRAHİM
Dilek F, Özçeker D, Güler EM, Özkaya E, Yazıcı M, Tamay Z, Koçyiğit A, Güler N. Plasma lipoxin A4 levels in childhood chronic spontaneous urticaria. Turk J Pediatr 2018; 60: 527-534. Chronic spontaneous urticaria (CSU) is an idiopathic inflammatory disorder. Despite great research progress, the pathogenesis of the disease is still not fully understood. Lipoxins (LXs) are autacoid lipid metabolites that are the first discovered members of a new genus named called `specialized proresolving mediators`. In this study, we aimed to investigate the possible role of LXA4 in the pathogenesis of CSU. Forty-two children with CSU and 25 healthy children were enrolled in the study. The demographic and clinical features of patients were evaluated, autologous serum skin tests (ASSTs), and routine laboratory assessments were performed. Disease activity was determined using the urticaria activity score. An enzyme-linked immunosorbent assay was used to evaluate LXA4 plasma levels. The median value of plasma LXA4 was found to be 60.8 ng/ml (interquartile range, 48.1-71.8) in CSU patients and 137.4 ng/ml (121.4-150.8) in the control group. The difference between the groups was statistically significant (p < 0.001). Additionally, the median plasma LXA4 levels in the ASST-positive patients were significantly reduced compared to the ASST-negative ones (45.8 [36.7-67.6] versus 63.8 [58.3-78.9] ng/ml, respectively, p < 0.05). Our results showed that diminished LXA4 biosynthesis may be a critical part of CSU pathogenesis in children, especially in patients with an autoimmune component.