Person: ASİL, TALIP
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Publication Metadata only Silent brain infarctions in patients with paroxismal atrial fibrillation(2014-10-01) Asil, TALİP; TASAL, A.; ALTINTAS, O.; NIFTALIYEV, E.; ASİL, TALIPPublication Metadata only The evaluation of vitamin D levels in patients with carpal tunnel syndrome(2016-07-01) Gursoy, AZİZE ESRA; Bilgen, HALİDE RENGİN; DURUYEN, Humeyra; ALTINTAS, Ozge; Kolukisa, MEHMET; Asil, TALİP; GÜRSOY, AZIZE ESRA; BİLGEN, HALİDE RENGİN; KOLUKISA, MEHMET; ASİL, TALIPThe aim of this study was to evaluate the relationship between 25-hydroxyvitamin D (25(OH)D) levels and carpal tunnel syndrome (CTS). 25(OH)D levels were checked in 108 consecutive patients with CTS symptoms and 52 healthy controls. All patients underwent nerve conduction studies and completed Boston Carpal Tunnel Questionnaire (BQ) symptom severity and functional status scales to quantify symptom severity, pain status and functional status. There were 57 patients with electrophysiological confirmed CTS (EP+ group) and 51 electrophysiological negative symptomatic patients (EP- group). 25(OH) D deficiency (25(OH)D < 20 ng/ml) was found in 96.1 % of EP- group, in 94.7 % of EP+ group and in 73.8 % of control group. 25(0H) D level was found significantly lower both in EP+ and EP- groups compared to control group (p = 0.006, p < 0.001, respectively). Although mean vitamin D level in EP- group was lower than EP+ group, statistically difference was not significant between EP+ and EP- groups (p = 0.182). BQ symptom severity and functional status scores and BQ pain sum score were not significantly different between EP+ and EP- groups. We found no correlation with 25(OH) D level for BQ symptom severity, functional status and pain sum scores. 25(OH) D deficiency is a common problem in patients with CTS symptoms. As evidenced by the present study, assessment of serum 25(OH)D is recommended in CTS patients even with electrophysiological negative results.Publication Metadata only Both Legs and Arms are Restless Restless Extremities Syndrome(2014-07-01) KOLUKISA, MEHMET; BABACAN YILDIZ, gülsen; GÜRSOY, AZİZE ESRA; ASIL, TALİP; KOLUKISA, MEHMET; BABACAN YILDIZ, GÜLSEN; GÜRSOY, AZIZE ESRA; ASİL, TALIPPublication Metadata only A 17-Year-Old Female with Systemic Lupus Presents with Complex Movement Disorder: Possible Relationship with Antiribosomal P Antibodies(2013-01-01T00:00:00Z) Ozcan, Muhammed Emin; Altinoz, Meric Adil; Karadeli, Hasan Huseyin; ASİL, Talip; Kocer, Abdulkadir; ASİL, TALIPComplex movement disorder is a relatively rare presentation of neurolupus. Antiphospholipid antibodies are associated with movement disorders likely via aberrant neuronal stimulation. Antiribosomal P antibodies have been previously associated with neuropsychiatric disorders but their correlation with movement disorder was not previously established. Our case report involves a 17-year-old Caucasian female patient positive for only antiribosomal P antibody and lupus anticoagulant who presented with a sudden onset of complex movement disorder. After complete cessation of physical signs with olanzapine, anticardiolipin and anti-beta 2 glycoprotein I antibodies became positive which indicates a likely discordance between movement disorder and antiphospholipid antibodies. This also indicates a potential causal role of antiribosomal P antibodies in inducing movement disorder.Publication Metadata only A Combined Power M-mode and Single Gate Transcranial Doppler Ultrasound Microemboli Signal Criteria for Improving Emboli Detection and Reliability(2010-10-01T00:00:00Z) CHOI, Youngbin; Saqqur, Maher; Asil, TALİP; JIN, Albert; STEWART, Eileen; STEPHENSON, Caroline; Ibrahim, Mohamad; ROY, Jayanta; BOULANGER, Jean-Martin; COUTTS, Shelagh; KHAN, Firosh; DEMCHUK, Andrew M.; ASİL, TALIPBACKGROUND AND PURPOSEPublication Metadata only Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience(2011-01-01T00:00:00Z) Asil, TALİP; Balci, Kemal; Utku, Ufuk; Ir, Nasif; ASİL, TALIPObjective: Intravenous (IV) thrombolytic therapy is the only approved effective treatment used in patients with acute ischemic stroke. In this study, we aimed at establishing the clinical outcomes of the IV tissue plasminogen activator (tPA) therapy and the main factors affecting the success rate of the treatment.Publication Metadata only Thrombus Migration and Fragmentation After Intravenous Alteplase Treatment The INTERRSeCT Study(2021-01-01T00:00:00Z) Ohara, Tomoyuki; Menon, Bijoy K.; Al-Ajlan, Fahad S.; Horn, MacKenzie; Najm, Mohamed; Al-Sultan, Abdulaziz; Puig, Josep; Dowlatshahi, Dar; Sanz, Ana I. Calleja; Sohn, Sung-Il; Ahn, Seong H.; Poppe, Alexandre Y.; Mikulik, Robert; Asdaghi, Negar; Field, Thalia S.; Jin, Albert; Asil, Talip; Boulanger, Jean-Martin; Letteri, Federica; Dey, Sadanand; Evans, James W.; Goyal, Mayank; Hill, Michael D.; Almekhlafi, Mohammed; Demchuk, Andrew M.; ASİL, TALIPBackground and Purpose:Publication Metadata only Validation of an automated ASPECTS method on non-contrast computed tomography scans of acute ischemic stroke patients(2020-07-01T00:00:00Z) Kuang, Hulin; Qiu, Wu; Najm, Mohamed; Dowlatshahi, Dar; Mikulik, Robert; Poppe, Alex Y.; Puig, Josep; Castellanos, Mar; Sohn, Sung; Ahn, Seong H.; Calleja, Ana; Jin, Albert; Asil, Talip; Asdaghi, Negar; Field, Thalia S.; Coutts, Shelagh; Hill, Michael D.; Demchuk, Andrew M.; Goyal, Mayank; Menon, Bijoy K.; ASİL, TALIPBackground The Alberta Stroke Program Early CT Score (ASPECTS) is a systematic method of assessing the extent of early ischemic change on non-contrast computed tomography in patients with acute ischemic stroke. Our objective was to validate an automated ASPECTS scoring method we recently developed on a large data set. Materials and methods We retrospectively collected 602 acute ischemic stroke patients- non-contrast computed tomography scans. Expert ASPECTS readings on non-contrast computed tomography were compared to automated ASPECTS. Statistical analyses on the total ASPECTS, region level ASPECTS, and dichotomized ASPECTS (4) score were conducted. Results In total, 602 scans were evaluated and 6020 (602 x 10) ASPECTS regions were scored. Median time from stroke onset to computed tomography was 114 min (interquartile range: 73-183 min). Total ASPECTS for the 602 patients generated by the automated method agreed well with expert readings (intraclass correlation coefficient): 0.65 (95% confidence interval (CI): 0.60-0.69). Region level analysis showed that the automated method yielded accuracy of 81.25%, sensitivity of 61.13% (95% CI: 58.4%-63.8%), specificity of 86.56% (95% CI: 85.6%-87.5%), and area under curve of 0.74 (95% CI: 0.73-0.75). For dichotomized ASPECTS (4), the automated method demonstrated sensitivity 97.21% (95% CI: 95.4%-98.4%), specificity 57.81% (95% CI: 44.8%-70.1%), accuracy 93.02%, and area under the curve of 0.78 (95% CI: 0.74-0.81). For each individual region (M1-6, lentiform, insula, and caudate), the automated method demonstrated acceptable performance. Conclusion The automated system we developed approached the stroke expert in performance when scoring ASPECTS on non-contrast computed tomography scans of acute ischemic stroke patients.Publication Metadata only Evaluation of cerebral hemodynamic status in patients with unilateral symptomatic carotid artery stenosis during motor tasks, through use of transcranial Doppler sonography(2022-04-01T00:00:00Z) Milanlıoğlu, Aysel; YAMAN KULA, ASLI; KOLUKISA, MEHMET; ASİL, Talip; YAMAN KULA, ASLI; KOLUKISA, MEHMET; ASİL, TALIPBackground: Carotid artery stenosis increases cerebral ischemic event risk through changing different cerebral hemodynamic parameters. Objective: To investigate how cerebral hemodynamics in the M1 segment of middle cerebral artery change in patients with carotid artery stenosis, after motor tasks using transcranial Doppler sonography (TCD). Methods: Thirty-two healthy subjects and 30 patients with unilateral symptomatic carotid artery stenosis were recruited. The patient population was divided into three groups according to the degree of stenosis (group 1: ≥50 to 69%, group 2: 70 to 89% and group 3: ≥90 to 99%). TCD was used to measure the pulsatility index (PI) and cerebral vasomotor reactivity (CVR). Results: In the patient group, significant differences for symptomatic side PI values (p=0.01) and mean CVR increases (p=0.05) were observed, compared with the healthy controls. However, the difference was not statistically significant for asymptomatic side PI values and mean CVR increases. The results from the intergroup comparison showed significantly higher percentages of symptomatic and asymptomatic side CVR increases in group 1, compared with groups 2 and 3 (p=0.001 and p=0.002, respectively). Conclusions: Our study showed that cerebral autoregulation and hemodynamic mechanisms are impaired in patients with carotid artery stenosis. Furthermore, the impairment of PI and CVR tends to get worse with increasing degrees of stenosis. In addition, this study demonstrated that assessment of these two hemodynamic parameters in clinical practice might be helpful for monitoring the progress of carotid artery stenosis.Publication Metadata only Neuromuscular transmission impairment in transient global amnesia(2013-10-01) Gursoy, AZİZE ESRA; BABACAN-YILDIZ, Gulsen; Kolukisa, MEHMET; Asil, TALİP; ERTAS, Mustafa; GÜRSOY, AZIZE ESRA; BABACAN YILDIZ, GÜLSEN; KOLUKISA, MEHMET; ASİL, TALIP