Person: ASİL, TALIP
5 results
Search Results
Now showing 1 - 5 of 5
Publication Metadata only Thrombus Migration and Fragmentation After Intravenous Alteplase Treatment The INTERRSeCT Study(2021-01-01T00:00:00Z) Ohara, Tomoyuki; Menon, Bijoy K.; Al-Ajlan, Fahad S.; Horn, MacKenzie; Najm, Mohamed; Al-Sultan, Abdulaziz; Puig, Josep; Dowlatshahi, Dar; Sanz, Ana I. Calleja; Sohn, Sung-Il; Ahn, Seong H.; Poppe, Alexandre Y.; Mikulik, Robert; Asdaghi, Negar; Field, Thalia S.; Jin, Albert; Asil, Talip; Boulanger, Jean-Martin; Letteri, Federica; Dey, Sadanand; Evans, James W.; Goyal, Mayank; Hill, Michael D.; Almekhlafi, Mohammed; Demchuk, Andrew M.; ASİL, TALIPBackground and Purpose:Publication Metadata only Validation of an automated ASPECTS method on non-contrast computed tomography scans of acute ischemic stroke patients(2020-07-01T00:00:00Z) Kuang, Hulin; Qiu, Wu; Najm, Mohamed; Dowlatshahi, Dar; Mikulik, Robert; Poppe, Alex Y.; Puig, Josep; Castellanos, Mar; Sohn, Sung; Ahn, Seong H.; Calleja, Ana; Jin, Albert; Asil, Talip; Asdaghi, Negar; Field, Thalia S.; Coutts, Shelagh; Hill, Michael D.; Demchuk, Andrew M.; Goyal, Mayank; Menon, Bijoy K.; ASİL, TALIPBackground The Alberta Stroke Program Early CT Score (ASPECTS) is a systematic method of assessing the extent of early ischemic change on non-contrast computed tomography in patients with acute ischemic stroke. Our objective was to validate an automated ASPECTS scoring method we recently developed on a large data set. Materials and methods We retrospectively collected 602 acute ischemic stroke patients- non-contrast computed tomography scans. Expert ASPECTS readings on non-contrast computed tomography were compared to automated ASPECTS. Statistical analyses on the total ASPECTS, region level ASPECTS, and dichotomized ASPECTS (4) score were conducted. Results In total, 602 scans were evaluated and 6020 (602 x 10) ASPECTS regions were scored. Median time from stroke onset to computed tomography was 114 min (interquartile range: 73-183 min). Total ASPECTS for the 602 patients generated by the automated method agreed well with expert readings (intraclass correlation coefficient): 0.65 (95% confidence interval (CI): 0.60-0.69). Region level analysis showed that the automated method yielded accuracy of 81.25%, sensitivity of 61.13% (95% CI: 58.4%-63.8%), specificity of 86.56% (95% CI: 85.6%-87.5%), and area under curve of 0.74 (95% CI: 0.73-0.75). For dichotomized ASPECTS (4), the automated method demonstrated sensitivity 97.21% (95% CI: 95.4%-98.4%), specificity 57.81% (95% CI: 44.8%-70.1%), accuracy 93.02%, and area under the curve of 0.78 (95% CI: 0.74-0.81). For each individual region (M1-6, lentiform, insula, and caudate), the automated method demonstrated acceptable performance. Conclusion The automated system we developed approached the stroke expert in performance when scoring ASPECTS on non-contrast computed tomography scans of acute ischemic stroke patients.Publication Metadata only Evaluation of cerebral hemodynamic status in patients with unilateral symptomatic carotid artery stenosis during motor tasks, through use of transcranial Doppler sonography(2022-04-01T00:00:00Z) Milanlıoğlu, Aysel; YAMAN KULA, ASLI; KOLUKISA, MEHMET; ASİL, Talip; YAMAN KULA, ASLI; KOLUKISA, MEHMET; ASİL, TALIPBackground: Carotid artery stenosis increases cerebral ischemic event risk through changing different cerebral hemodynamic parameters. Objective: To investigate how cerebral hemodynamics in the M1 segment of middle cerebral artery change in patients with carotid artery stenosis, after motor tasks using transcranial Doppler sonography (TCD). Methods: Thirty-two healthy subjects and 30 patients with unilateral symptomatic carotid artery stenosis were recruited. The patient population was divided into three groups according to the degree of stenosis (group 1: ≥50 to 69%, group 2: 70 to 89% and group 3: ≥90 to 99%). TCD was used to measure the pulsatility index (PI) and cerebral vasomotor reactivity (CVR). Results: In the patient group, significant differences for symptomatic side PI values (p=0.01) and mean CVR increases (p=0.05) were observed, compared with the healthy controls. However, the difference was not statistically significant for asymptomatic side PI values and mean CVR increases. The results from the intergroup comparison showed significantly higher percentages of symptomatic and asymptomatic side CVR increases in group 1, compared with groups 2 and 3 (p=0.001 and p=0.002, respectively). Conclusions: Our study showed that cerebral autoregulation and hemodynamic mechanisms are impaired in patients with carotid artery stenosis. Furthermore, the impairment of PI and CVR tends to get worse with increasing degrees of stenosis. In addition, this study demonstrated that assessment of these two hemodynamic parameters in clinical practice might be helpful for monitoring the progress of carotid artery stenosis.Publication Metadata only Assessment of Cerebral Vasomotor Reactivity in Patients With Primary Open-angle Glaucoma and Ocular Hypertension Using the Breath-Holding Index(2021-02-01T00:00:00Z) Arslan, Gurcan D.; Olgun, Ali; Ozcan, Delil; GÖKÇAL, ELİF; Guven, Dilek; ASİL, Talip; GÖKÇAL, ELİF; ASİL, TALIPPrecis: Patients with ocular hypertension (OHT) do not show impaired cerebral vasodilation responses to hypercapnia but patients with primary open-angle glaucoma (POAG) do. Impaired vasoreactivity in patients with POAG may have neuronal or vascular origins and increase stroke risk.Publication Metadata only Berberine Attenuates Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage Via Modulating AMPK/Rho Pathway(2020-01-01T00:00:00Z) Kadirhan, Ozge Altintas; Kumas, Meltem; Karatas, Ersin; Mutlu, Hasan Serdar; KOÇYİĞİT, ABDÜRRAHİM; Asil, Talip; KUMAŞ, MELTEM; KOÇYİĞİT, ABDÜRRAHİM; ASİL, TALIPPurpose: Our goal is to clarify the effectiveness of berberine (BBR) on cerebral vasospasm induced by subarachnoid hemorrhage.