Person: ASİL, TALIP
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Publication Open Access Spontaneous intracranial hypotension presenting with coma: a case report and literature review(2015-07-01T00:00:00Z) Celik, Yahya; Tekatas, Aslan; Albayram, Sait; Gunduz, Aysegul; Asil, TALİP; Unlu, Ercument; Ozlece Kose, Hatice; ASİL, TALIPSpontaneous intracranial hypotension is characterized by orthostatic headache in the absence of a history of head trauma or lumbar puncture, and diagnosis is confirmed by a specific cerebrospinal fluid pressure and neuroimaging findings. It rarely presents with coma. A 62-year-old man presented with progressive cognitive decline of 2 to 4 weeks- duration. He was diagnosed with spontaneous intracranial hypotension according to cerebrospinal fluid pressure and neuroimaging findings, and treated conservatively.Publication Metadata only Silent brain infarctions in patients with paroxismal atrial fibrillation(2014-10-01) Asil, TALİP; TASAL, A.; ALTINTAS, O.; NIFTALIYEV, E.; ASİL, TALIPPublication Metadata only The evaluation of vitamin D levels in patients with carpal tunnel syndrome(2016-07-01) Gursoy, AZİZE ESRA; Bilgen, HALİDE RENGİN; DURUYEN, Humeyra; ALTINTAS, Ozge; Kolukisa, MEHMET; Asil, TALİP; GÜRSOY, AZIZE ESRA; BİLGEN, HALİDE RENGİN; KOLUKISA, MEHMET; ASİL, TALIPThe aim of this study was to evaluate the relationship between 25-hydroxyvitamin D (25(OH)D) levels and carpal tunnel syndrome (CTS). 25(OH)D levels were checked in 108 consecutive patients with CTS symptoms and 52 healthy controls. All patients underwent nerve conduction studies and completed Boston Carpal Tunnel Questionnaire (BQ) symptom severity and functional status scales to quantify symptom severity, pain status and functional status. There were 57 patients with electrophysiological confirmed CTS (EP+ group) and 51 electrophysiological negative symptomatic patients (EP- group). 25(OH) D deficiency (25(OH)D < 20 ng/ml) was found in 96.1 % of EP- group, in 94.7 % of EP+ group and in 73.8 % of control group. 25(0H) D level was found significantly lower both in EP+ and EP- groups compared to control group (p = 0.006, p < 0.001, respectively). Although mean vitamin D level in EP- group was lower than EP+ group, statistically difference was not significant between EP+ and EP- groups (p = 0.182). BQ symptom severity and functional status scores and BQ pain sum score were not significantly different between EP+ and EP- groups. We found no correlation with 25(OH) D level for BQ symptom severity, functional status and pain sum scores. 25(OH) D deficiency is a common problem in patients with CTS symptoms. As evidenced by the present study, assessment of serum 25(OH)D is recommended in CTS patients even with electrophysiological negative results.Publication Open Access Combined Use of Invatec Mo.Ma Proximal Protection Device and Solitaire AB Retrievable Stent for Tandem Occlusions in a Patient With Acute Ischemic Stroke(2013-10-01) TASAL, Abdurrahman; Asil, TALİP; GOKTEKIN, Omer; ASİL, TALIPRecanalization of tandem vascular occlusions in the setting of an acute stroke is problematic. Here we report a successful treatment of an acute ischemic stroke with tandem cervical internal carotid artery and middle cerebral artery occlusions. A 56-year-old woman presented with acute left-sided hemiplegia. Diffusion magnetic resonance imaging showed an acute infarction in the right frontal and parietal lobes. We planned to perform rescue endovascular treatment after fibrinolytic therapy failed. Stent-assisted carotid angioplasty with proximal embolic protection device was followed by stent-based mechanical thrombectomy of the proximal middle cerebral artery occlusion. Her neurological condition improved after the procedure with National Institutes of Health Stroke Scale of 3 points. The combination of proximal embolic protection device and retrievable Solitaire stent could be a feasible and safe treatment strategy in acute ischemic stroke patients with extra- and intracranial tandem occlusions.Publication Metadata only A Combined Power M-mode and Single Gate Transcranial Doppler Ultrasound Microemboli Signal Criteria for Improving Emboli Detection and Reliability(2010-10-01T00:00:00Z) CHOI, Youngbin; Saqqur, Maher; Asil, TALİP; JIN, Albert; STEWART, Eileen; STEPHENSON, Caroline; Ibrahim, Mohamad; ROY, Jayanta; BOULANGER, Jean-Martin; COUTTS, Shelagh; KHAN, Firosh; DEMCHUK, Andrew M.; ASİL, TALIPBACKGROUND AND PURPOSEPublication Metadata only Intravenous tPA Administration in Patients With Acute Ischemic Stroke: Edirne Experience(2011-01-01T00:00:00Z) Asil, TALİP; Balci, Kemal; Utku, Ufuk; Ir, Nasif; ASİL, TALIPObjective: Intravenous (IV) thrombolytic therapy is the only approved effective treatment used in patients with acute ischemic stroke. In this study, we aimed at establishing the clinical outcomes of the IV tissue plasminogen activator (tPA) therapy and the main factors affecting the success rate of the treatment.Publication Open Access Splinting is effective for night-only symptomatic carpal tunnel syndrome patients(2015-04-01) HALAC, Gulistan; DEMIR, Saliha; Yucel, HÜLYA; NIFTALIYEV, Elvin; KOCAMAN, Gulsen; DURUYEN, Humeyra; KENDIRLI, Tansel; Asil, TALİP; YÜCEL, HÜLYA; ASİL, TALIP[Purpose] Carpal tunnel syndrome is the most common entrapment neuropathy of the median nerve. Splinting is one of the most used conservative treatment methods for carpal tunnel syndrome. The aim of this study was to show the effectiveness of splinting in carpal tunnel syndrome patients who were divided into two groups according to their level of symptoms. [Subjects and Methods] A total of 40 carpal tunnel syndrome patients were divided into 2 groups based on having symptoms only at night or during the day were included in this study. These two groups were compared at the end of a 3-months splinting therapy in terms of improvement of severity of symptoms, functional capacity, pain level, and electrophysiological findings. [Results] Pain levels of both groups were similar at baseline. After splinting, pain levels of night-only symptomatic patients were lower than those of sustained symptomatic ones. No differences were found in symptom severity, functional capacity, and the electrophysiological findings in either group after the splinting. [Conclusion] The results of this study show that splinting alone may be sufficient to decrease the pain for night-only symptomatic patients. Combined therapy methods may be needed for sustained symptomatic patientsPublication Metadata only Neuromuscular transmission impairment in transient global amnesia(2013-10-01) Gursoy, AZİZE ESRA; BABACAN-YILDIZ, Gulsen; Kolukisa, MEHMET; Asil, TALİP; ERTAS, Mustafa; GÜRSOY, AZIZE ESRA; BABACAN YILDIZ, GÜLSEN; KOLUKISA, MEHMET; ASİL, TALIPPublication Metadata only Association between cerebrovascular reactivity and white matter changes in patients with diabetes mellitus(2015-04-01) DURUYEN, H.; YAMAN, A.; TOKDEMIR, SEVİL; ARALASMAK, AYŞE; Asil, TALİP; TOKDEMİR, SEVİL; ARALAŞMAK, AYŞE; ASİL, TALIPPublication Open Access Higher minor hemoglobin A2 levels in multiple sclerosis patients correlate with lesser disease severity(2016-01-01) Ozcan, Muhammed Emin; INCE, Bahri; KARADELI, Hasan Huseyin; GEDIKBASI, Asuman; Asil, TALİP; Altinoz, Meric A.; ASİL, TALIPObjective: To define whether minor adult hemoglobin A2 (HbA2, α2δ2) exerts any protective activity in multiple sclerosis (MS). Methods: HbA2 levels were measured in 146 MS patients with high performance liquid chromatography and association with MS Severity Scores (MSSS) were determined. HbA2 associations with blood count parameters were also studied using blood counts evaluated on the same day of high performance liquid chromatography sampling. Routine biochemical parameters were also determined to rule out elusively influential factors, such as anemia and thyroid disorders. Results: HbA2 levels negatively correlated with MSSS (Spearman correlation, R: -0.186, P=0.025). Exclusion of confounding factors with a generalized linear model revealed an even stronger negative correlation between HbA2 and MSSS (P<0.001). HbA2 positively correlated with red blood cells (RBCs) (R=0.350, P<0.001) and in turn, RBCs negatively correlated with MSSS (R=-0.180, P=0.031). Average HbA2 levels were highest among patients treated with interferon β1a. Conclusion: RBC fragility is increased in MS, and recent data suggest that circulating free Hb contributes to neural injury in MS. HbA2 and its oxidative denaturation product hemichrome A2 enhance RBC membrane stability to a greater extent than do major HbA or hemichrome A. Reductions in ischemic cerebrovascular vascular events are reported in β-thalassemia carriers and HbA2 levels are considerably higher in this population. Episodic declines of cerebral blood flow were shown in bipolar disorder, and we have recently shown a protective role of HbA2 against postpartum episodes in females with bipolar disorder. HbA2's erythroprotective functions may reduce free Hb and long-term neural injury in MS.