Person: EŞREFOĞLU, MUKADDES
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Publication Metadata only Not only melatonin but also caffeic acid phenethyl ester protects kidneys against aging-related oxidative damage in Sprague Dawley rats.(2012-08-01) Eşrefoğlu, MUKADDES; IRAZ, M; ATES, B; GÜL, M; EŞREFOĞLU, MUKADDESPublication Metadata only The effects of caffeic acid phenethyl ester and melatonin on age-related vascular remodeling and cardiac damage.(2011-10-01) Eşrefoğlu, MUKADDES; GÜL, M; ATES, B; ERDOĞAN, A; EŞREFOĞLU, MUKADDESPublication Metadata only Cardioprotective potential of melatonin, quercetin and resveratrol in an experimental model of diabetes.(2021-04-28T00:00:00Z) Bostancıeri, N; Elbe, H; Eşrefoğlu, MUKADDES; Vardı, N; EŞREFOĞLU, MUKADDESPublication Metadata only The ultrastructural and biochemical evidences of the beneficial effects of chronic caffeic acid phenethyl ester and melatonin administration on brain and cerebellum of aged rats.(2010-06-01T00:00:00Z) Eşrefoğlu, MUKADDES; GÜL, M; ATES, B; YILMAZ, I; EŞREFOĞLU, MUKADDES; YILMAZ, İREMPublication Metadata only Beneficial effect of caffeic acid phenethyl ester (CAPE) on hepatocyte damage induced by bile duct ligation: an electron microscopic examination.(2010-10-01T00:00:00Z) Eşrefoğlu, MUKADDES; ARA, C; EŞREFOĞLU, MUKADDESPublication Open Access Petroselinum Crispum is Effective in Reducing Stress-Induced Gastric Oxidative Damage.(2017-01-01) AKıNCı, Ayşin; Eşrefoğlu, MUKADDES; TASLIDERE, ELİF; ATES, B; EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİFBackground: Oxidative stress has been shown to play a principal role in the pathogenesis of stress-induced gastric injury. Parsley (Petroselinum crispum) contains many antioxidants such as flavanoids, carotenoids and ascorbic acid. Aims: In this study, the histopathological and biochemical results of nutrition with a parsley-rich diet in terms of eliminating stress-induced oxidative gastric injury were evaluated. Study design: Animal experimentation. Methods: Forty male Wistar albino rats were divided into five groups: control, stress, stress + standard diet, stress + parsley-added diet and stress + lansoprazole (LPZ) groups. Subjects were exposed to 72 hours of fasting and later immobilized and exposed to the cold at +4 degrees for 8 hours to create a severe stress condition. Samples from the animals' stomachs were arranged for microscopic and biochemical examinations. Results: Gastric mucosal injury was obvious in rats exposed to stress. The histopathologic damage score of the stress group (7.00±0.57) was higher than that of the control group (1.50±0.22) (p<0.05). Significant differences in histopathologic damage score were found between the stress and stress + parsley-added diet groups (p<0.05), the stress and stress + standard diet groups (p<0.05), and the stress and stress + LPZ groups (p<0.05). The mean tissue malondialdehyde levels of the stress + parsley-added group and the stress + LPZ group were lower than that of the stress group (p<0.05). Parsley supported the cellular antioxidant system by increasing the mean tissue glutathione level (53.31±9.50) and superoxide dismutase (15.18±1.05) and catalase (16.68±2.29) activities. Conclusion: Oral administration of parsley is effective in reducing stress-induced gastric injury by supporting the cellular antioxidant defence system.Publication Metadata only Protective effect of β-glucan on acute lung injury induced by lipopolysaccharide in rats.(2015-01-01) Iraz, M; Eşrefoğlu, MUKADDES; AYDIN, MEHMET; EŞREFOĞLU, MUKADDESPublication Open Access A comprehensive study of myocardial redox homeostasis in naturally and mimetically aged rats(2014-01-01) CEBE, T; YANAR, K; ATUKEREN, P; OZAN, T; KURUÇ, AI; KUNBAZ, A; SITAR, ME; MENGI, M; AYDIN, MEHMET; Eşrefoğlu, MUKADDES; AYDıN, S; CAKATAY, U; EŞREFOĞLU, MUKADDESAge-related myocardial dysfunction has important implications with impaired redox homeostasis. Current study focused on investigation of redox homeostasis and histopathological changes in the myocardium of mimetically (MA), naturally aged (NA), and young control (YC) rats. Chronic D-galactose administration to young male Wistar rats (5 months old) was used to set up experimental aging models. We investigated 16 different oxidative damage biomarkers which have evaluated redox homeostasis of cellular macromolecules such as protein, lipid, and DNA. As a protein oxidation biomarker, advanced oxidation end products, protein carbonyl groups, protein-bound advanced glycation end products, dityrosine, kynurenine, and N-formylkynurenine concentrations in MA and NA rats were found to be significantly higher compared to those in YC rats. On the other hand, the levels of protein thiol groups were not significantly different between groups, whereas lipid peroxidation biomarkers such as conjugated diens, lipid hydroperoxides, and malondialdehyde in MA and NA rats were found to be significantly higher in comparison to those in YCs. For the assessment of oxidative DNA damage, we analyzed eight hydroxy-5'-deoxyguanosine concentrations of MA and NA groups which were higher than YCs. As an antioxidant status in the MA and NA groups, Cu-Zn superoxide dismutase, ferric reducing antioxidant power, and total thiol levels were lower than those in the YCs. Only nonprotein thiol levels were not significantly different. We also observed similar histopathological changes in MA and NA rats. We concluded that the mimetic aging model could be considered as a reliable experimental model for myocardial senescence.