Person: EŞREFOĞLU, MUKADDES
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Publication Metadata only Shea Yağının Yara İyileşmesi Üzerine Etkisi.(2016-05-03) BAYINDIR, NİHAN; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES; Kılıç, Elif; BULUT, HURİ; BAYINDIR, NİHAN; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES; BULUT, HURIPublication Metadata only Protective effects of caffeic acid phenethyl ester and thymoquinone on toluene induced liver toxicity.(2019-05-01) Esrefoglu, MUKADDES; Bayındır, NİHAN; KURBETLI, N; Selek, S; Akbas, Tosunoglu; Meydan, SEDAT; OZTURK, OSMAN; Bulut, HURİ; Meral, I; MEYDAN, SEDAT; EŞREFOĞLU, MUKADDES; SELEK, ŞAHABETTİN; ÖZTÜRK, OSMAN; BAYINDIR, NİHAN; BULUT, HURI; MERAL, İSMAİLPublication Metadata only Investigation of Anti-Oxidant and Toxicological Effects Of Methanolic Extract of Rosmarinus officinalis(2015-10-17) BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; BAYINDIR, NİHAN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDES; BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; BAYINDIR, NİHAN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDESPublication Open Access Antioxidant and toxicological in-vivo and in-vitro examination of licorice extract(2016-09-01) Bektay, MUHAMMED YUNUS; Uckaya, FATİH; Guler, E. M.; Bayindir, NİHAN; Kocyigit, ABDÜRRAHİM; Esrefoglu, MUKADDES; Topcu, GÜLAÇTI; BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; GÜLER, ERAY METİN; BAYINDIR, NİHAN; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTIPublication Open Access Protective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats(2016-12-01) Kumas, MELTEM; Esrefoglu, MUKADDES; Bayindir, NİHAN; Iraz, Meryem; Ayhan, Siddika; Meydan, SEDAT; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; BAYINDIR, NİHAN; MEYDAN, SEDATObjective: We aimed to investigate the protective effects of curcumin (Cr) against cadmium (Cd) toxicity on the kidneys of both young and aged rats. Methods: Forty-eight young and aged female Spraque–Dawley rats were divided into control, Cd, Cr, and Cd+Cr groups. We investigated kidney damage using a histopathological scoring system and measured total antioxidant status (TAS) and total oxidant status (TOS) and interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) levels. Results: Kidney tissues of Cd groups showed acute histopathological alterations. Cr improved Cd-induced histopathological changes (p<0.05). The highest mean TAS was recorded in both the Cr groups. The highest mean TOS was recorded only in the aged Cd group. Cr decreased IL-6 levels in both the Cd+Cr groups (p<0.05). PCT levels in the Cd groups were higher than those in the control groups. Significance was detected only between the young Cd and control groups (p<0.05). PCT levels were reduced in both the Cd+Cr groups (p<0.05). CRP levels in the aged Cd group were higher than those in the other groups (p<0.05). Cr reduced CRP levels only in the aged Cd+Cr group (p<0.05). Conclusion: Our results suggest that Cr prevents Cd-induced renal oxidative damage in both young and aged rats.Publication Metadata only Can ebselen prevent cisplatin-induced ovarian damage?(2018-06-01T00:00:00Z) Soyman, Zeynep; Uzun, Hafize; Bayindir, Nihan; EŞREFOĞLU, MUKADDES; Boran, Birtan; BAYINDIR, NİHAN; EŞREFOĞLU, MUKADDESPurpose The occurrence of ovarian damage is a major shortcoming in treating tumors with cisplatin (CP). The present study investigates the beneficial effects of ebselen-a seleno-organic compound with antioxidant and antiinflammatory properties-vis-a-vis CP-induced ovarian damage.Publication Metadata only Effects of Oenothera biennis L. and Hypericum perforatum L. extracts on some central nervous system myelin proteins, brain histopathology and oxidative stress in mice with experimental autoimmune encephalomyelitis.(2019-02-01) BULUT, HURİ; ESREFOGLU, MUKADDES; BAYINDIR, NİHAN; Meral, I; CAGLAR, HİFA GÜLRU; SELEK, S; YUCE, BÜŞRA; DOGAN, NAREG; TELOGLU, EMİNE ŞEYDA; SONUC, G; YILDIZ, C; TIFTIK, E; SELEK, ŞAHABETTİN; EŞREFOĞLU, MUKADDES; MERAL, İSMAİL; BULUT, HURI; ÇAĞLAR, HİFA GÜLRU; TELOĞLU, EMİNE ŞEYDA; YÜCE, BÜŞRA; BAYINDIR, NİHANPublication Metadata only Comparing healing effect against ulcerative colitis and toxicological effects of Rosmarinus officinalis: A comprehensive in vivo study of an edible plant in rats(2022-07-01T00:00:00Z) YILMAZ, ANIL; UÇKAYA, FATİH; BAYINDIR, NİHAN; GÜLER, ERAY METİN; TOPRAK, ALİ; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTI; UÇKAYA, FATİH; BAYINDIR, NİHAN; GÜLER, ERAY METİN; TOPRAK, ALİ; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTIUlcerative colitis (UC) is a chronic and inflammatory disorder of the gastrointestinal (GI) tract. UC usually worsens the daily life of the patient and may sometimes become mortal. There is no known remedy discovered against UC, yet. Rosmarinus officinalis consists of many flavonoids, phenolics, and terpenoids possessing various biological activities such as anti-inflammatory. For this reason, in the present study, anti-ulcerative colitis effect of ROME (Rosmarinus officinalis methanol extract) was investigated comprehensively by histopathological studies, a number of in vivo anti-inflammatory activities and several in vivo antioxidant activities, in addition to in vitro antioxidant activities and biochemical analyses. In addition, the toxic effects of ROME were examined. The results showed that ROME provided a significant healing effect against ulcerative colitis in rats. Both in vitro and in vivo assay results correlated with histopathological examinations. ROME exhibited minimal toxic alterations. When the results of rosemary are compared with the results of sulfasalazine, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various diseases. Although some activities of rosemary have been investigated in vitro in the previous studies, this is the first study revealing anti-ulcerative colitis effect of rosemary through histopathological studies, in vivo and in vitro assays as well as biochemical analyses overall. Practical applications The results revealed and proved that ROME provided a significant healing effect against ulcerative colitis in rats. When the results of rosemary are compared with the results of sulfasalazine, a commercially available drug on the market, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various inflammatory diseases such as UC disease. In addition, ROME possesses limited toxic alterations, but not much more than the commercial drug. As a future perspective, lethal and therapeutic doses can be examined and determined. Thus, human studies can be started through this comprehensive in vivo study on rosemary which is commonly used as an edible plant and spice all over the world.Publication Metadata only Therapeutic effects of Licorice (Glycyrrhiza glabra) on colitis through its antioxidant properties and biochemical analyses(2015-08-01) Uckaya, FATİH; Bektay, Yunus; Yilmaz, ANIL; Bayindir, NİHAN; Selek, ŞAHBETTİN; Topcu, GÜLAÇTI; Esrefoglu, MUKADDES; UÇKAYA, FATİH; BEKTAY, MUHAMMED YUNUS; YILMAZ, ANIL; BAYINDIR, NİHAN; SELEK, ŞAHABETTİN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDESPublication Metadata only Investigation of In-Vitro and In-Vivo Anti-Oxidant Effects of Matricaria chamomilla Extract on Rat Model of Ulcerative Colitis.(2015-08-31) Bektay, MUHAMMED YUNUS; BAYINDIR, NİHAN; EŞREFOĞLU, MUKADDES; Topçu, GÜLAÇTI; Üçkaya, FATİH; BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDES; BAYINDIR, NİHAN