Person: EŞREFOĞLU, MUKADDES
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Publication Metadata only Clues to the Harmful Effects of Aspartame on Liver Morphology and Function(2022-12-01) Hekimoğlu E. R.; Elibol B.; Toruntay C.; Kırmızıkan S.; Pasin Ö.; Sarıkaya U.; Alkhalidi D.; Eşrefoğlu M.; HEKİMOĞLU, EMİNE RÜMEYSA; KIRMIZIKAN, SEDA; PASİN, ÖZGE; SARIKAYA, UFUK; EŞREFOĞLU, MUKADDESPublication Metadata only Effects of melatonin on both testicular regeneration and recovery of spermatogenesis in busulfan-treated rats(2022-01-01) Taşlıdere E.; Eşrefoğlu M.; Tok O.; Taşlıdere B.; Bulut H.; EŞREFOĞLU, MUKADDES; TAŞLIDERE, BAHADIR; BULUT, HURITesticular damage is one of the most hazardous effects of chemotherapy as it is frequently associated with oligozoospermia and azoospermia. This study aimed at evaluating the protective effect of melatonin in a rat model of busulfan-induced testicular injury. Rats were divided into four groups: control, melatonin, busulfan, busulfan plus melatonin. After 15 days, the semen was collected from the epididymis and testes were assessed. Sperm removed from cauda epididymis and analyzed for sperm count and viability. Testis tissues were also removed, fixed in formalin and were embedded in paraffin. Sections of testis tissue were stained with hematoxylin-eosin for histological examination and prepared for TUNEL (Terminal deoxynucleotide transferase dUTP Nick End Labeling) assay to detect apoptosis and PCNA (proliferating cell nuclear antigenassay) to detect proliferation cells. Serum and testes supernatants were separated to detect testosteron level and oxidative stress parameters. In histological examination, degenerative changes in seminiferous tubules were observed in the experimental groups. In biochemical examination, the total oxidant status (TOS) levels in Busulfan group were significantly higher than in the control group while the total antioxidant status (TAS) levels of all the groups were similar. In conclusion, the beneficial properties of melatonin treatment by its potent anti-oxidants may reduce adverse effects of chemotherapy in the reproductive system in a rodent system.Publication Metadata only Ageing-related alterations in rat stomach and intestines: A microscopic approach(2023-03-01) Kırmızıkan S.; Eşrefoğlu M.; KIRMIZIKAN, SEDA; EŞREFOĞLU, MUKADDESPublication Metadata only Aging-related changes in rat kidney and testis: A microscopic approach(2022-11-01) Karakaya F. B.; Eşrefoğlu M.; KARAKAYA, FATMA BEDİA; EŞREFOĞLU, MUKADDESPublication Metadata only Specialized Pro-Resolving Lipid Mediators- New Therapeutic Approaches for Vascular Diseases(2023-11-23) Topal Tanyılmaz G.; Hekimoğlu E. R.; Eşrefoğlu M.; Çelik Z.; HEKİMOĞLU, EMİNE RÜMEYSA; EŞREFOĞLU, MUKADDESPublication Metadata only Beneficial effects of adipose-derived stromal vascular fraction on testicular injury caused by busulfan(2024-03-01) Hekimoğlu E. R.; Eşrefoğlu M.; Karakaya F. B.; Elibol B.; Dedeakayoğulları H.; Pasin Ö.; HEKİMOĞLU, EMİNE RÜMEYSA; EŞREFOĞLU, MUKADDES; KARAKAYA, FATMA BEDİA; PASİN, ÖZGE