Person: EŞREFOĞLU, MUKADDES
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Publication Open Access Comparison of Small-diameter-hole and Traditional Microfracture in Cartilage Repair and the Effect of Adding a Hyaluronic Acid-based Acellular Matrix Scaffold: An Animal Study(2021-03-01T00:00:00Z) UÇAN, VAHDET; YILDIZ, FATİH; ELMADAĞ, Nuh Mehmet; UZER, GÖKÇER; GÜZEL, YUNUS; TOK, OLGU ENİS; Mukaddes, E.; UÇAN, VAHDET; YILDIZ, FATİH; ELMADAĞ, NUH MEHMET; UZER, GÖKÇER; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDESObjective: Since, there is no standardized technique for the treatment of focal cartilage defects that can recreate original cartilage tissue; researchers continue to explore and evaluate various treatment modalities. This study compared post-operatke healing of cartilage defects after treatment with small-diameter-hole microfracture (SDHM) technique with that of traditional microfracture technique. The effects of the hole density and augmentation with hyaluronic acid-based acellular matrix (HA-based AM) on cartilage healing were also investigated. Methods: Articular cartilage defects measuring 5 mm in diameter and 3 mm in depth were created in each femoral trochlear groove of 21 New Zealand rabbits. Rabbits were assigned to seven groups comprising six knees each. The rabbits were sacrificed 12 weeks later, and the regenerated cartilage was harvested for histological evaluation using the Wakitani scoring system. Results: All defects were filled with regenerated tissue macroscopically. Group I (14; range 10-14 points) had significantly higher Wakitani score than in groups VI (6; range 1-11 points) and VII (5; range 3-10 points) (p=0.043 and p=0.016, respectively). No significant differences were observed among the other groups. Augmentation with HA-based AM did not contribute to cartilage healing. Conclusion: Improved cartilage healing was observed with increasing SDHM density than with traditional microfracture technique. SDHM combined with HA-based AM implantation did not improve the quality of the regenerated cartilage.Publication Metadata only Comparison of the efficacy of multiple antioxidant and hyperbaric oxygen treatments in the prevention of ischemia and necrosis of local random McFarlane skin flap.(2021-02-26T00:00:00Z) Dogan, Remzi; Metin Guler, Eray; Kocyigit, ABDÜRRAHİM; Bayindir, Nihan; Mirasoglu, Bengisu Oroglu; Yenigun, Alper; DOĞAN, REMZI; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; YENİGÜN, ALPER; ÖZTURAN, ORHANPublication Metadata only Özel Histoloji Geliştirilmiş 3. Baskı(2021-01-01T00:00:00Z) Eşrefoğlu, Mukaddes; EŞREFOĞLU, MUKADDESPublication Open Access Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentyleneterazole-PTZ Kindling in Rats.(2021-08-01T00:00:00Z) Meral, İsmail; Eşrefoğlu, Mukaddes; Kara, Mehmet; Erkeç, Özlem Ergül; Tok, Olgu Enis; Armağan, Metin; MERAL, İSMAİL; EŞREFOĞLU, MUKADDES; ÜSTÜNOVA, SAVAŞPublication Metadata only Clues to the Harmful Effects of Aspartame on Liver Morphology and Function(2022-12-01) Hekimoğlu E. R.; Elibol B.; Toruntay C.; Kırmızıkan S.; Pasin Ö.; Sarıkaya U.; Alkhalidi D.; Eşrefoğlu M.; HEKİMOĞLU, EMİNE RÜMEYSA; KIRMIZIKAN, SEDA; PASİN, ÖZGE; SARIKAYA, UFUK; EŞREFOĞLU, MUKADDESPublication Open Access The Cell Membrane: A Historical Narration(2020-01-01T00:00:00Z) KALKAN, KÜBRA TUĞÇE; EŞREFOĞLU, MUKADDES; KALKAN, KÜBRA TUĞÇE; EŞREFOĞLU, MUKADDESThe discovery of the structural elements of the cell has been entirely dependent on technological inventions. Although the discovery of cell membranes is thought to be in parallel with the discovery of microscopes, this is not exactly true. In the early 1660s, Robert Hooke made his first observation using a light microscope. In 1665, he examined a piece of fungus under a light microscope and he called each space as -cellula-. It was not already possible for him to see cell membranes with the primitive light microscope he used in this study. Also because the cells he was trying to study were plant cells, the lines that actually bounded the -cellula- were not the cell membrane, but the cell wall.In the following years,in addition to the microscopic observations, various physio-chemical studies were done in order to explore the structural and functional properties of the plasma membranes. In this review, the historical journey of the plasma membrane was summarized.Publication Metadata only Temel Histoloji(2022-10-01T00:00:00Z) Eşrefoğlu, Mukaddes; EŞREFOĞLU, MUKADDESPublication Metadata only Temel Histoloji(2022-10-01T00:00:00Z) Eşrefoğlu, Mukaddes; EŞREFOĞLU, MUKADDESPublication Metadata only Temel Histoloji(2022-10-01T00:00:00Z) Eşrefoğlu, Mukaddes; EŞREFOĞLU, MUKADDESPublication Metadata only Temel Histoloji(2022-10-01T00:00:00Z) Eşrefoğlu, Mukaddes; EŞREFOĞLU, MUKADDES